Identification of HSP90 inhibitors as a novel class of senolytics von Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.

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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice von Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.

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An aged immune system drives senescence and ageing of solid organs von Yousefzadeh, Matthew J., Flores, Rafael R., Zhu, Yi, Schmiechen, Zoe C., Brooks, Robert W., Trussoni, Christy E., Cui, Yuxiang, Angelini, Luise, Lee, Kyoo-A, McGowan, Sara J., Burrack, Adam L., Wang, Dong, Dong, Qing, Lu, Aiping, Sano, Tokio, O’Kelly, Ryan D., McGuckian, Collin A., Kato, Jonathan I., Bank, Michael P., Wade, Erin A., Pillai, Smitha P. S., Klug, Jenna, Ladiges, Warren C., Burd, Christin E., Lewis, Sara E., LaRusso, Nicholas F., Vo, Nam V., Wang, Yinsheng, Kelley, Eric E., Huard, Johnny, Stromnes, Ingunn M., Robbins, Paul D., Niedernhofer, Laura J.

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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs von Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C., Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K., Ikeno, Yuji, Hubbard, Gene B., Lenburg, Marc, O'Hara, Steven P., LaRusso, Nicholas F., Miller, Jordan D., Roos, Carolyn M., Verzosa, Grace C., LeBrasseur, Nathan K., Wren, Jonathan D., Farr, Joshua N., Khosla, Sundeep, Stout, Michael B., McGowan, Sara J., Fuhrmann‐Stroissnigg, Heike, Gurkar, Aditi U., Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S., Navarro, Diana C., Sano, Tokio, Robbins, Paul D., Niedernhofer, Laura J., Kirkland, James L.

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Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation von Zhao, Jing, Zhang, Lei, Mu, Xiaodong, Doebelin, Christelle, Nguyen, William, Wallace, Callen, Reay, Daniel P, McGowan, Sara J, Corbo, Lana, Clemens, Paula R, Wilson, Gabriela Mustata, Watkins, Simon C, Solt, Laura A, Cameron, Michael D, Huard, Johnny, Niedernhofer, Laura J, Kamenecka, Theodore M, Robbins, Paul D

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Fisetin is a senotherapeutic that extends health and lifespan von Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.

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Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging von Dorronsoro, Akaitz, Santiago, Fernando E., Grassi, Diego, Zhang, Tianpeng, Lai, Ruenn Chai, McGowan, Sara J., Angelini, Luise, Lavasani, Mitra, Corbo, Lana, Lu, Aiping, Brooks, Robert W., Garcia‐Contreras, Marta, Stolz, Donna B., Amelio, Antonio, Boregowda, Siddaraju V., Fallahi, Mohammad, Reich, Adrian, Ricordi, Camillo, Phinney, Donald G., Huard, Johnny, Lim, Sai Kiang, Niedernhofer, Laura J., Robbins, Paul D.

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Simultaneous Quantification of Methylated Cytidine and Adenosine in Cellular and Tissue RNA by Nano-Flow Liquid Chromatography–Tandem Mass Spectrometry Coupled with the Stable Isot... von Fu, Lijuan, Amato, Nicholas J, Wang, Pengcheng, McGowan, Sara J, Niedernhofer, Laura J, Wang, Yinsheng

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Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging von Zhang, Lei, Zhao, Jing, Mu, Xiaodong, McGowan, Sara J., Angelini, Luise, O'Kelly, Ryan D., Yousefzadeh, Matthew J., Sakamoto, Ayumi, Aversa, Zaira, LeBrasseur, Nathan K., Suh, Yousin, Huard, Johnny, Kamenecka, Theodore M., Niedernhofer, Laura J., Robbins, Paul D.

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Expansion of myeloid‐derived suppressor cells with aging in the bone marrow of mice through a NF‐κB‐dependent mechanism von Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong‐Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.

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ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging von Zhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J, Li, Xuesen, Gurkar, Aditi U, McGowan, Sara J, Angelini, Luise, O'Kelly, Ryan, Li, Hongshuai, Corbo, Lana, Sano, Tokio, Nick, Heather, Pola, Enrico, Pilla, Smitha P S, Ladiges, Warren C, Vo, Nam, Huard, Johnny, Niedernhofer, Laura J, Robbins, Paul D

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Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype von Ngo, Kevin, Patil, Prashanti, McGowan, Sara J., Niedernhofer, Laura J., Robbins, Paul D., Kang, James, Sowa, Gwendolyn, Vo, Nam

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Attenuation of ataxia telangiectasia mutated signalling mitigates age‐associated intervertebral disc degeneration von Han, Yingchao, Zhou, Chao‐Ming, Shen, Hongxing, Tan, Jun, Dong, Qing, Zhang, Lei, McGowan, Sara J., Zhao, Jing, Sowa, Gwendolyn A., Kang, James D., Niedernhofer, Laura J., Robbins, Paul D., Vo, Nam N.

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Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy von Henpita, Chathurika, Vyas, Rajesh, Healy, Chastity L., Kieu, Tra L., Gurkar, Aditi U., Yousefzadeh, Matthew J., Cui, Yuxiang, Lu, Aiping, Angelini, Luise A., O'Kelly, Ryan D., McGowan, Sara J., Chandrasekhar, Sanjay, Vanderpool, Rebecca R., Hennessy‐Wack, Danielle, Ross, Mark A., Bachman, Timothy N., McTiernan, Charles, Pillai, Smitha P. S., Ladiges, Warren, Lavasani, Mitra, Huard, Johnny, Beer‐Stolz, Donna, St. Croix, Claudette M., Watkins, Simon C., Robbins, Paul D., Mora, Ana L., Kelley, Eric E., Wang, Yinsheng, O'Connell, Timothy D., Niedernhofer, Laura J.

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Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas von McGowan, Sara L, Edelhauser, Henry F, Pfister, Roswell R, Whikehart, David R

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Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1d/− mice von Huerta Guevara, Ana P., McGowan, Sara J., Kazantzis, Melissa, Stallons, Tania Rozgaja, Sano, Tokio, Mulder, Niels L., Jurdzinski, Angelika, van Dijk, Theo H., Eggen, Bart J.L., Jonker, Johan W., Niedernhofer, Laura J., Kruit, Janine K.

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ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation von Czerwińska, Jolanta, Nowak, Małgorzata, Wojtczak, Patrycja, Dziuban-Lech, Dorota, Cieśla, Jarosław M., Kołata, Daria, Gajewska, Beata, Barańczyk-Kuźma, Anna, Robinson, Andria R., Shane, Hillary L., Gregg, Siobhán Q., Rigatti, Lora H., Yousefzadeh, Matthew J., Gurkar, Aditi U., McGowan, Sara J., Kosicki, Konrad, Bednarek, Małgorzata, Zarakowska, Ewelina, Gackowski, Daniel, Oliński, Ryszard, Speina, Elżbieta, Niedernhofer, Laura J., Tudek, Barbara

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The prevalence and causes of decreased visual acuity - a study based on vision screening conducted at Enukweni and Mzuzu Foundation Primary Schools, Malawi von Thom, Leaveson, Jogessar, Sanchia, McGowan, Sara L, Lawless, Fiona

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Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1 mice von Huerta Guevara, Ana P., McGowan, Sara J., Kazantzis, Melissa, Stallons, Tania Rozgaja, Sano, Tokio, Mulder, Niels L., Jurdzinski, Angelika, van Dijk, Theo H., Eggen, Bart J.L., Jonker, Johan W., Niedernhofer, Laura J., Kruit, Janine K.

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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging von Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M., Frantz, Marie-Céline, Bell-Temin, Harris, Pope-Varsalona, Hannah, Gurkar, Aditi U., Nasto, Luigi A., Robinson, Renã A.S., Fuhrmann-Stroissnigg, Heike, Czerwinska, Jolanta, McGowan, Sara J., Cantu-Medellin, Nadiezhda, Harris, Jamie B., Maniar, Salony, Ross, Mark A., Trussoni, Christy E., LaRusso, Nicholas F., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Tudek, Barbara, Vo, Nam V., Rigatti, Lora H., Opresko, Patricia L., Stolz, Donna B., Watkins, Simon C., Burd, Christin E., Croix, Claudette M. St, Siuzdak, Gary, Yates, Nathan A., Robbins, Paul D., Wang, Yinsheng, Wipf, Peter, Kelley, Eric E., Niedernhofer, Laura J.

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