Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives von McGowan, Meredeth A, McAvoy, Camille Z, Buchwald, Stephen L

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Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors von Pu, Qinglin, Zhang, Hongjun, Guo, Liangqin, Cheng, Mangeng, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, McGowan, Meredeth A, Miller, J. Richard, Geda, Prasanthi, Song, Xuelei, Otte, Karin, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Sloman, David L, Zhou, Hua, Lammens, Alfred, Neumann, Lars, Bennett, David Jonathan, Pasternak, Alexander, Han, Yongxin

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Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy von Zhang, Hongjun, Liu, Kun, Pu, Qinglin, Achab, Abdelghani, Ardolino, Michael J, Cheng, Mangeng, Deng, Yongqi, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Knemeyer, Ian, Kurukulasuriya, Ravi, Lam, Yu-hong, Lesburg, Charles A, Martinot, Theodore A, McGowan, Meredeth A, Miller, J. Richard, Otte, Karin, Biju, Purakattle J, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Zhou, Hua, Wang, Xiao, Bennett, David Jonathan, Han, Yongxin

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Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase‑1 (IDO1) von White, Catherine, McGowan, Meredeth A, Zhou, Hua, Sciammetta, Nunzio, Fradera, Xavier, Lim, Jongwon, Joshi, Elizabeth M, Andrews, Christine, Nickbarg, Elliott B, Cowley, Phillip, Trewick, Sarah, Augustin, Martin, von Köenig, Konstanze, Lesburg, Charles A, Otte, Karin, Knemeyer, Ian, Woo, Hyun, Yu, Wensheng, Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Curran, Patrick, Heo, Mee Ra, Abeywickrema, Pravien, Miller, J. Richard, Bennett, David Jonathan, Han, Yongxin

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An Enantioselective Total Synthesis of (+)-Peloruside A von McGowan, Meredeth A., Stevenson, Christian P., Schiffler, Matthew A., Jacobsen, Eric N.

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Enantioselective Formal Aza-Diels–Alder Reactions of Enones with Cyclic Imines Catalyzed by Primary Aminothioureas von Lalonde, Mathieu P, McGowan, Meredeth A, Rajapaksa, Naomi S, Jacobsen, Eric N

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Enantioselective Total Synthesis of (+)-Reserpine von Rajapaksa, Naomi S, McGowan, Meredeth A, Rienzo, Matthew, Jacobsen, Eric N

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Palladium-Catalyzed N-Arylation of 2-Aminothiazoles von McGowan, Meredeth A, Henderson, Jaclyn L, Buchwald, Stephen L

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Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing von Li, Derun, Sloman, David L, Achab, Abdelghani, Zhou, Hua, McGowan, Meredeth A, White, Catherine, Gibeau, Craig, Zhang, Hongjun, Pu, Qinglin, Bharathan, Indu, Hopkins, Brett, Liu, Kun, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, Martinot, Theodore A, Qi, Ji, Song, Zhiguo J, Yin, Jingjun, Zhang, Huangguang, Song, Licheng, Wan, Baoqiang, DAddio, Suzanne, Solban, Nicolas, Miller, J Richard, Zamlynny, Beata, Bass, Alan, Freeland, Elizabeth, Ykoruk, Bridget, Hilliard, Catherine, Ferraro, Jude, Zhai, Jin, Knemeyer, Ian, Otte, Karin M, Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin

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Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators von Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors von Zhou, Hua, McGowan, Meredeth A., Lipford, Kathryn, Christopher, Matthew, Fradera, Xavier, Witter, David, Lesburg, Charles A., Li, Chaomin, Methot, Joey L., Lampe, John, Achab, Abdelghani, Shaffer, Lynsey, Goldenblatt, Peter, Shah, Sanjiv, Bass, Alan, Schroeder, Gottfried, Chen, Dapeng, Zeng, Haoyu, Augustin, Martin A., Katz, Jason D.

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Discovery of a new series of PI3K-δ inhibitors from Virtual Screening von Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.

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SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors von Yu, Wensheng, Deng, Yongqi, Hopkins, Brett, Huang, Xianhai, Sloman, David, Zhang, Hongjun, Li, Derun, McGowan, Meredeth A., White, Catherine, Pu, Qinglin, Liu, Kun, Fradera, Xavier, Lesburg, Charles A., Martinot, Theo, Doty, Amy, Ferguson, Heidi, Nickbarg, Elliott B., Cheng, Mangeng, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Abeywickrema, Pravien, Andrews, Christine, Chamberlin, Chad, Mabrouk, Omar, Curran, Patrick, Richards, Matthew, Saradjian, Peter, Miller, J. Richard, Knemeyer, Ian, Otte, Karin, Vincent, Stella, Sciammetta, Nunzio, Bennett, David Jonathan, Han, Yongxin

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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability von Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D

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Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580] von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

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Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors von Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D

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Synthesis of bis-4H-furo[3,4-b]indoles von McGowan, Meredeth A., Perreault, Denise M., Thornton, Nancy B., Garaas, Sarah D., Gribble, Gordon W.

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ChemInform Abstract: Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives von McGowan, Meredeth A., McAvoy, Camille Z., Buchwald, Stephen L.

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ChemInform Abstract: Palladium-Catalyzed N-Arylation of 2-Aminothiazoles von McGowan, Meredeth A., Henderson, Jaclyn L., Buchwald, Stephen L.

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