Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis von Yoo, Woongjae, Shealy, Nicolas G., Zieba, Jacob K., Torres, Teresa P., Baltagulov, Madi, Thomas, Julia D., Shelton, Catherine D., McGovern, Anna G., Foegeding, Nora J., Olsan, Erin E., Byndloss, Mariana X.

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease von Rivas, Manuel A, Daly, Mark J, Beaudoin, Mélissa, Gardet, Agnes, Stevens, Christine, Sharma, Yashoda, Zhang, Clarence K, Boucher, Gabrielle, Ripke, Stephan, Ellinghaus, David, Burtt, Noel, Fennell, Tim, Kirby, Andrew, Latiano, Anna, Goyette, Philippe, Green, Todd, Halfvarson, Jonas, Haritunians, Talin, Korn, Joshua M, Kuruvilla, Finny, Lagacé, Caroline, Neale, Benjamin, Lo, Ken Sin, Schumm, Phil, Törkvist, Leif, Dubinsky, Marla C, Brant, Steven R, Silverberg, Mark S, Duerr, Richard H, Altshuler, David, Gabriel, Stacey, Lettre, Guillaume, Franke, Andre, D'Amato, Mauro, McGovern, Dermot P B, Cho, Judy H, Rioux, John D, Xavier, Ramnik J

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Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases von Šimurina, Mirna, de Haan, Noortje, Vučković, Frano, Kennedy, Nicholas A., Štambuk, Jerko, Falck, David, Trbojević-Akmačić, Irena, Clerc, Florent, Razdorov, Genadij, Khon, Anna, Latiano, Anna, D'Incà, Renata, Danese, Silvio, Targan, Stephan, Landers, Carol, Dubinsky, Marla, Campbell, Harry, Zoldoš, Vlatka, Permberton, Iain K., Kolarich, Daniel, Fernandes, Daryl L., Theorodorou, Evropi, Merrick, Victoria, Spencer, Daniel I., Gardner, Richard A., Doran, Ray, Shubhakar, Archana, Boyapati, Ray, Rudan, Igor, Lionetti, Paolo, Krištić, Jasminka, Novokmet, Mislav, Pučić-Baković, Maja, Gornik, Olga, Andriulli, Angelo, Cantoro, Laura, Sturniolo, Giancarlo, Fiorino, Gionata, Manetti, Natalia, Arnott, Ian D., Noble, Colin L., Lees, Charlie W., Shand, Alan G., Ho, Gwo-Tzer, Dunlop, Malcolm G., Murphy, Lee, Gibson, Jude, Evenden, Louise, Wrobel, Nicola, Gilchrist, Tamara, Fawkes, Angie, Kammeijer, Guinevere S.M., Vojta, Aleksandar, Samaržija, Ivana, Markulin, Dora, Klasić, Marija, Dobrinić, Paula, Aulchenko, Yurii, van den Heuve, Tim, Jonkers, Daisy, Pierik, Marieke, McGovern, Dermot P.B., Annese, Vito, Wuhrer, Manfred, Lauc, Gordan

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Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease von Ventham, N. T., Kennedy, N. A., Adams, A. T., Kalla, R., Heath, S., O'Leary, K. R., Drummond, H., Wilson, D. C., Gut, I. G., Nimmo, E. R., Satsangi, J.

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Quantifying prion disease penetrance using large population control cohorts von Minikel, EV, Vallabh, SM, Lek, M, Estrada, K, Samocha, KE, Sathirapongsasuti, JF, McLean, CY, Tung, JY, Yu, LPC, Gambetti, P, Blevins, J, Zhang, SL, Cohen, Y, Chen, W, Yamada, M, Hamaguchi, T, Sanjo, N, Mizusawa, H, Nakamura, Y, Kitamoto, T, Collins, SJ, Boyd, A, Will, RG, Knight, R, Ponto, C, Zerr, I, Kraus, TFJ, Eigenbrod, S, Giese, A, Calero, M, de Pedro-Cuesta, J, Haik, S, Laplanche, JL, Bouaziz-Amar, E, Brandel, JP, Capellari, S, Parchi, P, Poleggi, A, Ladogana, A, O'Donnell-Luria, AH, Karczewski, KJ, Marshall, JL, Boehnke, M, Laakso, M, Mohlke, KL, Kahler, A, Chambert, K, McCarroll, S, Sullivan, PF, Hultman, CM, Purcell, SM, Sklar, P, van der Lee, SJ, Rozemuller, A, Jansen, C, Hofman, A, Kraaij, R, van Rooij, JGJ, Ikram, MA, Uitterlinden, AG, van Duijn, CM, Daly, MJ, MacArthur, DG

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Patient Perceptions on the Follow-Up of Abnormal Cancer Screening Test Results von Atlas, Steven J, Gallagher, Katherine L, McGovern, Sydney E, Wint, Amy J, Smith, Rebecca E, Aman, David G, Zhao, Wenyan, Burdick, Timothy E, Orav, E John, Zhou, Li, Wright, Adam, Tosteson, Anna N A, Haas, Jennifer S

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High-density mapping of the MHC identifies a shared role for HLA-DRB1 ☆ 01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis von Goyette, P, Boucher, G, Mallon, D, Ellinghaust, E, Jostins, L, Huang, H, Ripke, S, Gusareva, ES, Annese, V, Hauser, SL

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease von van Heel, David A, Ghosh, Subrata, Butler, Matt, Hunt, Karen A, Lundberg, Anna MC, Ahmad, Tariq, McGovern, Dermot PB, Onnie, Clive, Negoro, Kenichi, Goldthorpe, Sue, Foxwell, Brian MJ, Mathew, Christopher G, Forbes, Alastair, Jewell, Derek P, Playford, Raymond J

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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs von Lee, S Hong, Ripke, Stephan, Neale, Benjamin M, Faraone, Stephen V, Purcell, Shaun M, Perlis, Roy H, Mowry, Bryan J, Thapar, Anita, Goddard, Michael E, Witte, John S, Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A, Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E, Asherson, Philip, Azevedo, Maria H, Backlund, Lena, Badner, Judith A, Bailey, Anthony J, Banaschewski, Tobias, Barchas, Jack D, Barnes, Michael R, Barrett, Thomas B, Bass, Nicholas, Battaglia, Agatino, Bauer, Michael, Bayés, Mònica, Bellivier, Frank, Bergen, Sarah E, Berrettini, Wade, Betancur, Catalina, Bettecken, Thomas, Biederman, Joseph, Binder, Elisabeth B, Black, Donald W, Blackwood, Douglas H R, Bloss, Cinnamon S, Boehnke, Michael, Boomsma, Dorret I, Breen, Gerome, Breuer, René, Bruggeman, Richard, Cormican, Paul, Buccola, Nancy G, Buitelaar, Jan K, Bunney, William E, Buxbaum, Joseph D, Byerley, William F, Byrne, Enda M, Caesar, Sian, Cahn, Wiepke, Cantor, Rita M, Casas, Miguel, Chakravarti, Aravinda, Chambert, Kimberly, Choudhury, Khalid, Cichon, Sven, Cloninger, C Robert, Collier, David A, Cook, Edwin H, Coon, Hilary, Cormand, Bru, Corvin, Aiden, Coryell, William H, Craig, David W, Craig, Ian W, Crosbie, Jennifer, Cuccaro, Michael L, Curtis, David, Czamara, Darina, Datta, Susmita, Dawson, Geraldine, Day, Richard, De Geus, Eco J, Degenhardt, Franziska, Djurovic, Srdjan, Donohoe, Gary J, Doyle, Alysa E, Duan, Jubao, Dudbridge, Frank, Duketis, Eftichia, Ebstein, Richard P, Edenberg, Howard J, Elia, Josephine, Ennis, Sean, Etain, Bruno, Fanous, Ayman, Farmer, Anne E, Ferrier, I Nicol, Flickinger, Matthew, Fombonne, Eric, Foroud, Tatiana, Frank, Josef, Franke, Barbara, Fraser, Christine

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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids von Reimer, Katharina C., Nagai, James S., Varghese, Finny S., Overheul, Gijs J., Roverts, Rona, Willemsen, Brigith, Beukenboom, Marcel, Dunnen, Wilfred den, Triana, Sergio H., Timm, Marie-Cherelle, van den Berge, Bartholomeus T., Nlandu, Quincy, Heijnert, Joelle, Bindels, Eric M.J., Hoogenboezem, Remco M., Mooren, Fieke, Kuppe, Christoph, Grünberg, Katrien, Steenbergen, Eric J., Czogalla, Jan, Sommerdijk, Nico, Akiva, Anat, Boor, Peter, Huber, Tobias B., Bar-David, Elad, Barr, Haim, Boby, Melissa L., Borden, Bruce, Bowman, Gregory R., Brun, Juliane, BVNBS, Sarma, Carbery, Anna, Chernychenko, Eugene, Clyde, Austin, Coffland, Joseph E., Cole, Jason, Cox, Lisa, Dudgeon, Tim, Dunnett, Louise, Erez, Noam, Fate, Gwen, Ferrins, Lori, Foster, Richard, Foster, Holly, Gabizon, Ronen, Gawriljuk, Victor O., Gehrtz, Paul, Gileadi, Carina, Giroud, Charline, Glen, Robert, Gorichko, Marian, Griffen, Ed J., Heer, Jag, Hill, Michelle, Horrell, Sam, Jajack, Andrew, De Jonghe, Steven, Kantsadi, Anastassia L., Koekemoer, Lizbe, Lee, Alpha A., Lefker, Bruce A., Macdonald, Hannah Bruce, Maclean, Beth, McCorkindale, Willam, McGovern, Briana L., Michurin, Oleg, Morris, Aaron, Morris, Garret M., Neyts, Johan, Oliva, Glaucius, Overheul, Gijs J., Owen, David, Psenak, Vladimir, Pai, Ruby, Paran, Nir, Perry, Benjamin, Pingle, Maneesh, Politi, Boaz, Powell, Ailsa, Puni, Reut, Resnick, Efrat, Rosales, Romel, Schofield, Chris, Shafeev, Mikhail, Sittner, Assa, Skyner, Rachael, Spencer, John, Tamir, Hadas, Tennant, Rachael, Tumber, Anthony, van Rij, Ronald P., Voelz, Vincent, Volkamer, Andra, von Delft, Annette, White, Kris M., Wright, Nathan, Zidane, Hadeer, Costa, Ivan G., Schneider, Rebekka K., Smeets, Bart

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Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study von Cleynen, Isabelle, PhD, Boucher, Gabrielle, MSc, Jostins, Luke, PhD, Schumm, L Philip, MA, Zeissig, Sebastian, PhD, Ahmad, Tariq, PhD, Andersen, Vibeke, Prof, Andrews, Jane M, Prof, Annese, Vito, MD, Brand, Stephan, Prof, Brant, Steven R, MD, Cho, Judy H, Prof, Daly, Mark J, Prof, Dubinsky, Marla, MD, Duerr, Richard H, Prof, Ferguson, Lynnette R, Prof, Franke, Andre, Prof, Gearry, Richard B, Prof, Goyette, Philippe, PhD, Hakonarson, Hakon, Prof, Halfvarson, Jonas, MD, Hov, Johannes R, PhD, Huang, Hailang, PhD, Kennedy, Nicholas A, PhD, Kupcinskas, Limas, Prof, Lawrance, Ian C, Prof, Lee, James C, PhD, Satsangi, Jack, Prof, Schreiber, Stephan, Prof, Théâtre, Emilie, PhD, van der Meulen-de Jong, Andrea E, MD, Weersma, Rinse K, Prof, Wilson, David C, Prof, Parkes, Miles, PhD, Vermeire, Severine, Prof, Rioux, John D, Prof, Mansfield, John, MD, Silverberg, Mark S, PhD, Radford-Smith, Graham, PhD, McGovern, Dermot P B, Prof, Barrett, Jeffrey C, Dr, Lees, Charlie W, Dr

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Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study von Silverberg, Mark S, Cho, Judy H, Rioux, John D, McGovern, Dermot P B, Wu, Jing, Annese, Vito, Achkar, Jean-Paul, Goyette, Philippe, Scott, Regan, Xu, Wei, Barmada, M Michael, Klei, Lambertus, Daly, Mark J, Abraham, Clara, Bayless, Theodore M, Bossa, Fabrizio, Griffiths, Anne M, Ippoliti, Andrew F, Lahaie, Raymond G, Latiano, Anna, Paré, Pierre, Proctor, Deborah D, Regueiro, Miguel D, Steinhart, A Hillary, Targan, Stephan R, Schumm, L Philip, Kistner, Emily O, Lee, Annette T, Gregersen, Peter K, Rotter, Jerome I, Brant, Steven R, Taylor, Kent D, Roeder, Kathryn, Duerr, Richard H

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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology von Rossin, Elizabeth J, Lage, Kasper, Raychaudhuri, Soumya, Xavier, Ramnik J, Tatar, Diana, Benita, Yair, Cotsapas, Chris, Daly, Mark J

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Trust and trustworthy artificial intelligence: A research agenda for AI in the environmental sciences von Bostrom, Ann, Demuth, Julie L., Wirz, Christopher D., Cains, Mariana G., Schumacher, Andrea, Madlambayan, Deianna, Bansal, Akansha Singh, Bearth, Angela, Chase, Randy, Crosman, Katherine M., Ebert‐Uphoff, Imme, Gagne, David John, Guikema, Seth, Hoffman, Robert, Johnson, Branden B., Kumler‐Bonfanti, Christina, Lee, John D., Lowe, Anna, McGovern, Amy, Przybylo, Vanessa, Radford, Jacob T., Roth, Emilie, Sutter, Carly, Tissot, Philippe, Roebber, Paul, Stewart, Jebb Q., White, Miranda, Williams, John K.

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Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell-Airway Smooth Muscle Cell Communication through Membrane Conduits von Farahnak, Soroor, McGovern, Toby K, Kim, Rachael, O'Sullivan, Michael, Chen, Brian, Lee, Minhyoung, Yoshie, Haruka, Wang, Anna, Jang, Joyce, Al Heialy, Saba, Lauzon, Anne-Marie, Martin, James G

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Prevalence of mismatch repair deficiency in a large prospective prostate cancer cohort von McNevin, Ciara S., Mohammed Nur, Mutaz, O'Brien, Cathal, McGovern, Brianan, McFadden, Julia, Baird, Anne-Marie, Cadoo, Karen Anne, Barr, Martin P, Gray, Steven G., Keogh, Anna P., Sheils, Orla, Sutton, Lesley Ann, Flanagan, Sinead, Mucci, Lorelei A, Stopsack, Konrad H., Finn, Stephen P.

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477a A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF PRA023 AS INDUCTION THERAPY IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: ARTEMISUC, COHO... von Sands, Bruce E., Peyrin-Biroulet, Laurent, Danese, Silvio, Rubin, David T., Vermeire, Severine, Ma, Christopher, Ritter, Timothy, Panaccione, Remo, Feagan, Brian G., Mcgovern, Dermot P.B., Laurent, Olivier, Luo, Allison, Nguyen, Deanna D., Lu, JD, Wiechowska-Kozlowska, Anna, Leszczyszyn, Jaroslaw, Kempinski, Radoslaw, Kierkus, Jaroslaw, Targan, Stephan

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Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population von Rivas, Manuel A, Avila, Brandon E, Koskela, Jukka, Huang, Hailiang, Stevens, Christine, Pirinen, Matti, Haritunians, Talin, Neale, Benjamin M, Kurki, Mitja, Ganna, Andrea, Graham, Daniel, Glaser, Benjamin, Peter, Inga, Atzmon, Gil, Barzilai, Nir, Levine, Adam P, Schiff, Elena, Pontikos, Nikolas, Weisburd, Ben, Lek, Monkol, Karczewski, Konrad J, Bloom, Jonathan, Minikel, Eric V, Petersen, Britt-Sabina, Beaugerie, Laurent, Seksik, Philippe, Cosnes, Jacques, Schreiber, Stefan, Bokemeyer, Bernd, Bethge, Johannes, Heap, Graham, Ahmad, Tariq, Plagnol, Vincent, Segal, Anthony W, Targan, Stephan, Turner, Dan, Saavalainen, Paivi, Farkkila, Martti, Kontula, Kimmo, Palotie, Aarno, Brant, Steven R, Duerr, Richard H, Silverberg, Mark S, Rioux, John D, Weersma, Rinse K, Franke, Andre, Jostins, Luke, Anderson, Carl A, Barrett, Jeffrey C, MacArthur, Daniel G, Jalas, Chaim, Sokol, Harry, Xavier, Ramnik J, Pulver, Ann, Cho, Judy H, McGovern, Dermot P B, Daly, Mark J

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Anti-Sp4 and anti-CCAR1 autoantibodies in UK vs US patients with adult and juvenile-onset anti-TIF1γ-positive myositis von McMorrow, Fionnuala K, Wedderburn, Lucy R, Chinoy, Hector, Oldroyd, Alexander, Lamb, Janine A, Rider, Lisa G, Mammen, Andrew L, Casciola-Rosen, Livia, McHugh, Neil J, Tansley, Sarah L, Armon, Kate, Coke, Louise, Cook, Julie, Nichols, Amy, McCann, Liza, Roberts, Ian, Baildam, Eileen, Hanna, Louise, Lloyd, Olivia, Wadeson, Susan, Andrews, Michelle, Roach, Jane, Riley, Phil, McGovern, Ann, Cuthbert, Verna, Ryder, Clive, Scott, Janis, Thomas, Beverley, Southwood, Taunton, Al-Abadi, Eslam, Howman, Ruth, Wyatt, Sue, Jackson, Gillian, Wood, Mark, Amin, Tania, VanRooyen, Vanessa, Burton, Deborah, Turner, Louise, Rostron, Heather, Hanson, Sarah, Davidson, Joyce, Gardner-Medwin, Janet, Martin, Neil, Ferguson, Sue, Waxman, Liz, Browne, Michael, Boyle, Roisin, Blyth, Emily, Cathcart, Susanne, Friswell, Mark, Foster, Helen, Swift, Alison, Jandial, Sharmila, Stevenson, Vicky, Wade, Debbie, Sen, Ethan, Smith, Eve, Qiao, Lisa, Watson, Stuart, Duong, Claire, Crulley, Stephen, Davies, Andrew, Miller, Miss Caroline, Bell, Lynne, McErlane, Flora, Sampath, Sunil, Bennet, Josh, King, Sharon, Venning, Helen, Satyapal, Rangaraj, Stretton, Elizabeth, Jordan, Mary, Mosley, Ellen, Frost, Anna, Crate, Lindsay, Warrier, Kishore, Stafford, Stefanie, Wrest, Brogan, Chou, Chia-Ping, Pryce, Paul, Wedderburn, Lucy, Pilkington, Clarissa, Hasson, Nathan, Al-Obadi, Muthana, Varnier, Giulia, Lacassagne, Sandrine, Maillard, Sue, Stone, Lauren, Halkon, Elizabeth, Brown, Virginia, Juggins, Audrey, Smith, Sally, Lunt, Sian, Enayat, Elli, Varsani, Hemlata, Kassoumeri, Laura, Beard, Miss Laura, Arnold, Katie, Glackin, Yvonne, Simou, Stephanie

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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis von Stamps, Dalton T, Dube, Shishir, Li, Dalin, Yang, Shaohong, Landers, Carol J, Mengesha, Emebet, Murali, Ramachandran, Potdar, Alka A, Wolf, Andrea J, Botwin, Gregory J, Khrom, Michelle, Faubion, William A, Sandler, Robert S, Sartor, R Balfour, Brant, Steven R, Rioux, John D, Schumm, L Philip, Silverberg, Mark S, Zaghiyan, Karen, Melmed, Gil Y, Vasiliauskas, Eric A, Syal, Gaurav, Bonthala, Nirupama N, Targan, Stephan R, Michelsen, Kathrin S, Ahmad, Tariq, Amininejad, Leila, Andersen, Vibeke, Aumais, Guy, Baidoo, Leonard, Bayless, Theodore M, Bethge, Johannes, Boucher, Gabrielle, Brand, Stephan, Chew, Angela, Cho, Judy H, Cohain, Ariella, Jong, Dirk De, Denson, Lee A, Dewit, Olivier, D'Inca, Renata, Edwards, Cathryn, Ellinghaus, David, Festen, Eleonora A, Florin, Tim, Gieger, Christian, Goyette, Philippe, Green, Todd, Griffiths, Anne M, Hakonarson, Hakon, Hanigan, Katherine, Hart, Ailsa, Hayward, Nicholas K, Hugot, Jean-Pierre, Hui, Ken Y, Imielinski, Marcin, Jonaitis, Laimas, Jostins, Luke, Kiudelis, Gediminas, Krishnaprasad, Krupa, Kugathasan, Subra, Lee, James C, Lees, Charlie W, Leja, Marcis, Louis, Edouard, Mitrovic, Mitja, Ng, Aylwin, Ng, Siew C, Evelyn Ng, Sok Meng, Nikolaus, Susanna, Oikonomou, Ioannis, Phillips, Anne, Ponsioen, Cyriel Y, Prescott, Natalie J, Raychaudhuri, Soumya, Rieder, Florian, Rioux, John D, Ripke, Stephan, Russell, Richard K, Sanderson, Jeremy D, Satsangi, Jack, Schreiber, Stefan, Philip Schumm, L, Scott, Regan, Silverberg, Mark S, Simms, Lisa A, Spain, Sarah L, Sventoraityte, Jurgita, Torkvist, Leif, Tremelling, Mark, Vasiliauskas, Eric, Vermeire, Severine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Wei, Zhi, Winkelmann, Juliane, Zhang, Clarence K, Zhang, Wei, Zhao, Zhen Z

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