Whole Systems Within Whole Systems: The Oregon Health Plan's Expansion of Services for Back and Neck Pain von Eaves, Emery R., Hsu, Clarissa W., DeBar, Lynn L., Livingston, Catherine J., Ocker, Laura E., McDonald, Sarah J., Dillon-Sumner, Laurel, Ritenbaugh, Cheryl

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Cost-effectiveness of psychological treatments for post-traumatic stress disorder in adults von Mavranezouli, Ifigeneia, Megnin-Viggars, Odette, Grey, Nick, Bhutani, Gita, Leach, Jonathan, Daly, Caitlin, Dias, Sofia, Welton, Nicky J, Katona, Cornelius, El-Leithy, Sharif, Greenberg, Neil, Stockton, Sarah, Pilling, Stephen

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Early Active Mobilization during Mechanical Ventilation in the ICU von Hodgson, Carol L, Bailey, Michael, Bellomo, Rinaldo, Brickell, Kathy, Broadley, Tessa, Buhr, Heidi, Gabbe, Belinda J, Gould, Doug W, Harrold, Meg, Higgins, Alisa M, Hurford, Sally, Iwashyna, Theodore J, Serpa Neto, Ary, Nichol, Alistair D, Presneill, Jeffrey J, Schaller, Stefan J, Sivasuthan, Janani, Tipping, Claire J, Webb, Steven, Young, Paul J

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Longitudinal analyses reveal immunological misfiring in severe COVID-19 von Lucas, Carolina, Wong, Patrick, Klein, Jon, Castro, Tiago B. R., Silva, Julio, Sundaram, Maria, Ellingson, Mallory K., Mao, Tianyang, Oh, Ji Eun, Israelow, Benjamin, Takahashi, Takehiro, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Mohanty, Subhasis, Wang, Haowei, Wyllie, Anne L., Vogels, Chantal B. F., Earnest, Rebecca, Lapidus, Sarah, Ott, Isabel M., Moore, Adam J., Muenker, M. Catherine, Fournier, John B., Campbell, Melissa, Odio, Camila D., Casanovas-Massana, Arnau, Herbst, Roy, Shaw, Albert C., Medzhitov, Ruslan, Schulz, Wade L., Grubaugh, Nathan D., Dela Cruz, Charles, Farhadian, Shelli, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

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The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled... von Price, Andrew, Hudson, Jemma, Leal, Jose, Campbell, Helen, Fitzpatrick, Ray, Arden, Nigel, Murray, David, Campbell, Marion K, Donell, Simon, Waite, Jonathan, Arden, Nigel, Beard, David, Campbell, Helen, Carr, Andrew, Fitzpatrick, Ray, Cook, Jonathan, Fernie, Gordon, McDonald, Alison, Castillo, Mayret, Fusco, Francesco, Holland, Kay, Regan, Sandra, Stalker, Victoria, Forrest, Mark, McPherson, Gladys, Boachie, Charles, Cruden, Janice, Halpin, Sophie, Smith, Beverley, Mullins, Mark Mullins, Blazeby, Jane, Lewis, Mark, Beverland, Beverland, Bryce, Leeann, Doran, Emer, Ali, Fazal, Jennings, Andrew, Rose, Glynis, Marynissen, Hans, Richards, Lyndsey, Pegler, Suzannah, Woodruffe, Claire, Cook, Joss, Dearnley, Kim, Banher, Sandhu, Horohan, Jamie, Jain, Sunil, Thompson, Susan, Buckley, Sarah, Ng, Aaron, Simeson, Karen, Flynn, Julian, Newsom, Meryl, Innes, Alison, Culley, Winifred, Ledingham, Bill, Stephen, Janis, Bray, Rachel, Eldridge, Jonathan, Morrison, Leigh, Porteous, Andrew, Robinson, James, Dawson, Matt, Dharmarajan, Raj, Hage, Will, Kelsall, Nicci, Venkatesh, Hemanth, Wild, Michelle, Jackson, William, Duncan, Stefanie, Heeley, Cheryl, Guy, Kramer, Jackson, Rosalyn, Higgins, Gordon, Hockings, Michael, Barber, Lindsey, Cochrane, Helen, Curtis, Janette, Grindey, Julie, Turner, Phil, Hill, Briony, Bowditch, Mark, Pryke, Steven, Suresh, Sheeba, Ashford, Robert, Cockburn, Susan, Godsiff, Steven, Haines, Christina, Carpio, Racquel, dos Remedios, Ian, Chapman-Sheath, Phil, Grabau, Caroline, Trevithick, Catherine, Howes, Mandy, Netherton, Kimberley, Travis, Nikki, Maqsood, Mohammad, Rashid, Farzana, Raynor, Alison, Rowsell, Mark

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Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial von Maughan, Timothy S, Prof, Adams, Richard A, FRCP, Smith, Christopher G, BSc, Meade, Angela M, DPhil, Seymour, Matthew T, Prof, Wilson, Richard H, MD, Idziaszczyk, Shelley, MPhil, Harris, Rebecca, MSc, Fisher, David, MSc, Kenny, Sarah L, MSc, Kay, Edward, BA, Mitchell, Jenna K, BHSc, Madi, Ayman, MRCP, Jasani, Bharat, Prof, James, Michelle D, BSc, Bridgewater, John, MD, Kennedy, M John, MD, Claes, Bart, MSc, Lambrechts, Diether, PhD, Kaplan, Richard, Prof, Cheadle, Jeremy P, Prof

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Persistent Coxsackievirus B3 Infection in Pancreatic Ductal Cells In Vitro Downregulates Cellular Polyamine Metabolism von Mastrodomenico, Vincent, LoMascolo, Natalie J, Firpo, Mason R, Villanueva Guzman, Maria Del Mar, Zaporowski, Adam, Mounce, Bryan C

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The Role of Arch Compression and Metatarsophalangeal Joint Dynamics in Modulating Plantar Fascia Strain in Running von McDonald, Kirsty A, Stearne, Sarah M, Alderson, Jacqueline A, North, Ian, Pires, Neville J, Rubenson, Jonas

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Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland von McGurnaghan, Stuart J, Weir, Amanda, Bishop, Jen, Kennedy, Sharon, Blackbourn, Luke A K, McAllister, David A, Hutchinson, Sharon, Caparrotta, Thomas M, Mellor, Joseph, Jeyam, Anita, O'Reilly, Joseph E, Wild, Sarah H, Hatam, Sara, Höhn, Andreas, Colombo, Marco, Robertson, Chris, Lone, Nazir, Murray, Janet, Butterly, Elaine, Petrie, John, Kennon, Brian, McCrimmon, Rory, Lindsay, Robert, Pearson, Ewan, Sattar, Naveed, McKnight, John, Philip, Sam, Collier, Andrew, McMenamin, Jim, Smith-Palmer, Alison, Goldberg, David, McKeigue, Paul M, Colhoun, Helen M, Whettlock, Alice, McLeod, Allan, Gasiorowski, Andrew, Merrick, Andrew, McAuley, Andy, Went, April, Purdie, Calum, Fischbacher, Colin, Ramsey, Colin, Bailey, David, Henderson, David, McDonald, Eisin, Drennan, Genna, Gowans, Graeme, Reid, Graeme, Murdoch, Heather, Carruthers, Jade, Murray, Josie, Heatlie, Karen, Donaldson, Lorraine, Paton, Martin, Reid, Martin, Llano, Melissa, Murphy-Hall, Michelle, Hall, Ross, Cameron, Ross, Brownlie, Susan, Gaffney, Adam, Milne, Aynsley, Sullivan, Christopher, McArdle, Edward, Glass, Elaine, Young, Johanna, Malcolm, William, McCoubrey, Jodie

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Risk of Heart Failure in Breast Cancer Patients After Anthracycline and Trastuzumab Treatment: A Retrospective Cohort Study von AIELLO BOWLES, Erin J, WELLMAN, Robert, HABEL, Laurel A, ULCICKAS YOOD, Marianne, MCCARTY, Catherine, MAGID, David J, WAGNER, Edward H, SPENCER FEIGELSON, Heather, ONITILO, Adedayo A, FREEDMAN, Andrew N, DELATE, Thomas, ALLEN, Larry A, NEKHLYUDOV, Larissa, GODDARD, Katrina A. B, DAVIS, Robert L

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Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs von Vlasova, Anastasia N, Paim, Francine C, Kandasamy, Sukumar, Alhamo, Moyasar A, Fischer, David D, Langel, Stephanie N, Deblais, Loic, Kumar, Anand, Chepngeno, Juliet, Shao, Lulu, Huang, Huang-Chi, Candelero-Rueda, Rosario A, Rajashekara, Gireesh, Saif, Linda J

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Sex differences in immune responses that underlie COVID-19 disease outcomes von Takahashi, Takehiro, Ellingson, Mallory K., Wong, Patrick, Israelow, Benjamin, Lucas, Carolina, Klein, Jon, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Liu, Feimei, Meir, Amit, Sun, Jonathan, Wang, Eric Y., Casanovas-Massana, Arnau, Wyllie, Anne L., Vogels, Chantal B. F., Earnest, Rebecca, Lapidus, Sarah, Ott, Isabel M., Moore, Adam J., Shaw, Albert, Fournier, John B., Odio, Camila D., Farhadian, Shelli, Dela Cruz, Charles, Grubaugh, Nathan D., Schulz, Wade L., Ring, Aaron M., Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

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Diverse functional autoantibodies in patients with COVID-19 von Wang, Eric Y., Mao, Tianyang, Klein, Jon, Dai, Yile, Huck, John D., Jaycox, Jillian R., Liu, Feimei, Zhou, Ting, Israelow, Benjamin, Wong, Patrick, Coppi, Andreas, Lucas, Carolina, Silva, Julio, Oh, Ji Eun, Song, Eric, Perotti, Emily S., Zheng, Neil S., Fischer, Suzanne, Campbell, Melissa, Fournier, John B., Wyllie, Anne L., Vogels, Chantal B. F., Ott, Isabel M., Kalinich, Chaney C., Petrone, Mary E., Watkins, Anne E., Dela Cruz, Charles, Farhadian, Shelli F., Schulz, Wade L., Ma, Shuangge, Grubaugh, Nathan D., Ko, Albert I., Iwasaki, Akiko, Ring, Aaron M.

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Daclatasvir plus Sofosbuvir for HCV in Patients Coinfected with HIV-1 von Wyles, David L, Ruane, Peter J, Sulkowski, Mark S, Dieterich, Douglas, Luetkemeyer, Anne, Morgan, Timothy R, Sherman, Kenneth E, Dretler, Robin, Fishbein, Dawn, Gathe, Joseph C, Henn, Sarah, Hinestrosa, Federico, Huynh, Charles, McDonald, Cheryl, Mills, Anthony, Overton, Edgar Turner, Ramgopal, Moti, Rashbaum, Bruce, Ray, Graham, Scarsella, Anthony, Yozviak, Joseph, McPhee, Fiona, Liu, Zhaohui, Hughes, Eric, Yin, Philip D, Noviello, Stephanie, Ackerman, Peter

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Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses von McDonald, Sarah D, Han, Zhen, Mulla, Sohail, Beyene, Joseph

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Living systematic review: 1. Introduction—the why, what, when, and how von Synnot, Anneliese, Turner, Tari, Simmonds, Mark, Akl, Elie A., McDonald, Steve, Salanti, Georgia, Meerpohl, Joerg, MacLehose, Harriet, Hilton, John, Tovey, David, Shemilt, Ian, Hilton, John, Akl, Elie, Pestridge, Charlotte, Horsley, Tanya, Armstrong, Rebecca, Plovnick, Robert, Arno, Anneliese, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Low, Nicola, Sherifali, Diana, Churchill, Rachel, MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Martin, Nicole, Martínez García, Laura, Danko, Kristen, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Meerpohl, Joerg, Tugwell, Peter, Merner, Bronwen, Featherstone, Robin, Mondello, Stefania, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Munafo, Marcus, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Newman, Kristine, Watts, Chris, Nieuwlaat, Robby, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Hartling, Lisa, Wiercioch, Wojtek, Wolfenden, Luke, Pahwa, Manisha, Yepes Nuñez, Juan José, Yost, Jennifer, Hill, Sophie, Pearson, Leslea

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Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomi... von Rodger, Marc A, Prof, Hague, William M, Prof, Kingdom, John, Prof, Kahn, Susan R, Prof, Karovitch, Alan, MD, Sermer, Mathew, Prof, Clement, Anne Marie, RN, Coat, Suzette, PhD, Chan, Wee Shian, MD, Said, Joanne, MBBS, Rey, Evelyne, MD, Robinson, Sue, Prof, Khurana, Rshmi, MD, Demers, Christine, MD, Kovacs, Michael J, Prof, Solymoss, Susan, MD, Hinshaw, Kim, MBBS, Dwyer, James, MBBS, Smith, Graeme, Prof, McDonald, Sarah, MD, Newstead-Angel, Jill, MD, McLeod, Anne, MD, Khandelwal, Meena, Prof, Silver, Robert M, Prof, Le Gal, Gregoire, Prof, Greer, Ian A, Prof, Keely, Erin, Prof, Rosene-Montella, Karen, Prof, Walker, Mark, MD, Wells, Philip S, Prof

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De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias von Helbig, Katherine L., Lauerer, Robert J., Bahr, Jacqueline C., Souza, Ivana A., Uysal, Betül, Gandini, Maria A., Huang, Sun, Keren, Boris, Mignot, Cyril, Billette de Villemeur, Thierry, Nava, Caroline, Valence, Stéphanie, Buratti, Julien, Fagerberg, Christina R., Soerensen, Kristina P., Kamsteeg, Erik-Jan, Koolen, David A., Gunning, Boudewijn, Schelhaas, H. Jurgen, Fox, Jordana, Bakhtiari, Somayeh, Jarrar, Randa, Lindstrom, Kristin, Jin, Sheng Chih, Zeng, Xue, Bilguvar, Kaya, Papavasileiou, Antigone, Xing, Qinghe, Zhu, Changlian, Boysen, Katja, Vairo, Filippo, Klee, Eric W., Tillema, Jan-Mendelt, Payne, Eric T., Cousin, Margot A., Kruisselbrink, Teresa M., Wick, Myra J., Baker, Joshua, Smith, Nicholas, Angrist, Misha, Ashley, Patricia, Bidegain, Margarita, Chambers, Eileen, Cope, Heidi, Cotten, C. Michael, Curington, Theresa, Davis, Erica E., Fisher, Kimberley, French, Amanda, Gallentine, William, Hill, Kevin, Kansagra, Sujay, Katsanis, Sara, Kurtzberg, Joanne, Marcus, Jeffrey, McDonald, Marie, Mikati, Mohammed, Miller, Stephen, Murtha, Amy, Perilla, Yezmin, Pizoli, Carolyn, Ross, Sherry, Sadeghpour, Azita, Smith, Edward, Wiener, John, Corbett, Mark A., Goldmann, Eva, Kichula, Elizabeth, Segal, Eric, Jackson, Kelly E., Asamoah, Alexander, McCarrier, Julie, Botto, Lorenzo D., Tvrdik, Tatiana, Cascino, Gregory D., Klingerman, Sherry, Neumann, Catherine, Nolan, Melinda A., Snell, Russell G., Lehnert, Klaus, Sadleir, Lynette G., Kvarnung, Malin, Guerrini, Renzo, Friez, Michael J., Lyons, Michael J., Leonhard, Jennifer, Kringlen, Gabriel, El Achkar, Christelle M., Smith, Lacey A., Carss, Keren J., Rankin, Julia, Zeman, Adam, Blyth, Moira, Kerr, Bronwyn, Ruiz, Karla, Urquhart, Jill, Banka, Siddharth, Scheffer, Ingrid E., Zamponi, Gerald W., Mefford, Heather C.

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Living systematic reviews: 4. Living guideline recommendations von Akl, Elie A., Meerpohl, Joerg J., Elliott, Julian, Kahale, Lara A., Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Au, Agnes, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Low, Nicola, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Skoetz, Nicole, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, Elliott, Julian, Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Wallace, Byron, Murano, Melissa, Wallace, Sheila A., Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie

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Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 M... von Adams, Richard A, FRCP, Meade, Angela M, DPhil, Seymour, Matthew T, Prof, Wilson, Richard H, MD, Madi, Ayman, MRCP, Fisher, David, MSc, Kenny, Sarah L, MSc, Kay, Edward, BA, Hodgkinson, Elizabeth, BPharm, Pope, Malcolm, Rogers, Penny, BSc, Wasan, Harpreet, FRCP, Falk, Stephen, MD, Gollins, Simon, DPhil, Hickish, Tamas, MD, Bessell, Eric M, PhD, Propper, David, MD, Kennedy, M John, MD, Kaplan, Richard, Prof, Maughan, Timothy S, Prof

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