Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer von Best, Sarah A., Gubser, Patrick M., Sethumadhavan, Shalini, Kersbergen, Ariena, Negrón Abril, Yashira L., Goldford, Joshua, Sellers, Katherine, Abeysekera, Waruni, Garnham, Alexandra L., McDonald, Jackson A., Weeden, Clare E., Anderson, Dovile, Pirman, David, Roddy, Thomas P., Creek, Darren J., Kallies, Axel, Kingsbury, Gillian, Sutherland, Kate D.

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Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy von Potts, Margaret A, McDonald, Jackson A, Sutherland, Kate D, Herold, Marco J

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On Target: An Intrapulmonary Transplantation Method for Modelling Lung Tumor Development in its Native Microenvironment von McDonald, Jackson A., Scott, Leanne, Van Zuylekom, Jessica, Holloway, Steven, Blyth, Benjamin J., Sutherland, Kate D.

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Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer von Weeden, Clare E., Gayevskiy, Velimir, Marceaux, Claire, Batey, Daniel, Tan, Tania, Yokote, Kenta, Ribera, Nina Tubau, Clatch, Allison, Christo, Susan, Teh, Charis E., Mitchell, Andrew J., Trussart, Marie, Rankin, Lucille, Obers, Andreas, McDonald, Jackson A., Sutherland, Kate D., Sharma, Varun J., Starkey, Graham, D’Costa, Rohit, Antippa, Phillip, Leong, Tracy, Steinfort, Daniel, Irving, Louis, Swanton, Charles, Gordon, Claire L., Mackay, Laura K., Speed, Terence P., Gray, Daniel H.D., Asselin-Labat, Marie-Liesse

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Abstract A043: Identifying critical vulnerabilities that sensitise Lkb1 -mutant lung adenocarcinoma to T cell mediated killing von McDonald, Jackson A, Boyd, Danielle, Diepstraten, Sarah, Scott, Leanne, Tai, Lin, Kueh, Andrew, Burr, Marian, Best, Sarah A, Herold, Marco J, Sutherland, Kate D

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Inflammation and Cancer: Methods and Protocols von Jenkins, Brendan J

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Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke von Campbell, Bruce C.V, Mitchell, Peter J, Churilov, Leonid, Yassi, Nawaf, Kleinig, Timothy J, Dowling, Richard J, Yan, Bernard, Bush, Steven J, Dewey, Helen M, Thijs, Vincent, Scroop, Rebecca, Simpson, Marion, Brooks, Mark, Asadi, Hamed, Wu, Teddy Y, Shah, Darshan G, Wijeratne, Tissa, Ang, Timothy, Miteff, Ferdinand, Levi, Christopher R, Rodrigues, Edrich, Zhao, Henry, Salvaris, Patrick, Garcia-Esperon, Carlos, Bailey, Peter, Rice, Henry, de Villiers, Laetitia, Brown, Helen, Redmond, Kendal, Leggett, David, Fink, John N, Collecutt, Wayne, Wong, Andrew A, Muller, Claire, Coulthard, Alan, Mitchell, Ken, Clouston, John, Mahady, Kate, Field, Deborah, Ma, Henry, Phan, Thanh G, Chong, Winston, Chandra, Ronil V, Slater, Lee-Anne, Krause, Martin, Harrington, Timothy J, Faulder, Kenneth C, Steinfort, Brendan S, Bladin, Christopher F, Sharma, Gagan, Desmond, Patricia M, Parsons, Mark W, Donnan, Geoffrey A, Davis, Stephen M

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Case 19-2020: A 74-Year-Old Man with Acute Respiratory Failure and Unclear Goals of Care von Jacobsen, Juliet C, Tran, Kathy M, Jackson, Vicki A, Rubin, Emily B

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De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias von Helbig, Katherine L., Lauerer, Robert J., Bahr, Jacqueline C., Souza, Ivana A., Uysal, Betül, Gandini, Maria A., Huang, Sun, Keren, Boris, Mignot, Cyril, Billette de Villemeur, Thierry, Nava, Caroline, Valence, Stéphanie, Buratti, Julien, Fagerberg, Christina R., Soerensen, Kristina P., Kamsteeg, Erik-Jan, Koolen, David A., Gunning, Boudewijn, Schelhaas, H. Jurgen, Fox, Jordana, Bakhtiari, Somayeh, Jarrar, Randa, Lindstrom, Kristin, Jin, Sheng Chih, Zeng, Xue, Bilguvar, Kaya, Papavasileiou, Antigone, Xing, Qinghe, Zhu, Changlian, Boysen, Katja, Vairo, Filippo, Klee, Eric W., Tillema, Jan-Mendelt, Payne, Eric T., Cousin, Margot A., Kruisselbrink, Teresa M., Wick, Myra J., Baker, Joshua, Smith, Nicholas, Angrist, Misha, Ashley, Patricia, Bidegain, Margarita, Chambers, Eileen, Cope, Heidi, Cotten, C. Michael, Curington, Theresa, Davis, Erica E., Fisher, Kimberley, French, Amanda, Gallentine, William, Hill, Kevin, Kansagra, Sujay, Katsanis, Sara, Kurtzberg, Joanne, Marcus, Jeffrey, McDonald, Marie, Mikati, Mohammed, Miller, Stephen, Murtha, Amy, Perilla, Yezmin, Pizoli, Carolyn, Ross, Sherry, Sadeghpour, Azita, Smith, Edward, Wiener, John, Corbett, Mark A., Goldmann, Eva, Kichula, Elizabeth, Segal, Eric, Jackson, Kelly E., Asamoah, Alexander, McCarrier, Julie, Botto, Lorenzo D., Tvrdik, Tatiana, Cascino, Gregory D., Klingerman, Sherry, Neumann, Catherine, Nolan, Melinda A., Snell, Russell G., Lehnert, Klaus, Sadleir, Lynette G., Kvarnung, Malin, Guerrini, Renzo, Friez, Michael J., Lyons, Michael J., Leonhard, Jennifer, Kringlen, Gabriel, El Achkar, Christelle M., Smith, Lacey A., Carss, Keren J., Rankin, Julia, Zeman, Adam, Blyth, Moira, Kerr, Bronwyn, Ruiz, Karla, Urquhart, Jill, Banka, Siddharth, Scheffer, Ingrid E., Zamponi, Gerald W., Mefford, Heather C.

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Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke von Ma, Henry, Campbell, Bruce C.V, Parsons, Mark W, Churilov, Leonid, Levi, Christopher R, Hsu, Chung, Kleinig, Timothy J, Wijeratne, Tissa, Curtze, Sami, Dewey, Helen M, Miteff, Ferdinand, Tsai, Chon-Haw, Lee, Jiunn-Tay, Phan, Thanh G, Mahant, Neil, Sun, Mu-Chien, Krause, Martin, Sturm, Jonathan, Grimley, Rohan, Chen, Chih-Hung, Hu, Chaur-Jong, Wong, Andrew A, Field, Deborah, Sun, Yu, Barber, P. Alan, Sabet, Arman, Jannes, Jim, Jeng, Jiann-Shing, Clissold, Benjamin, Markus, Romesh, Lin, Ching-Huang, Lien, Li-Ming, Bladin, Christopher F, Christensen, Søren, Yassi, Nawaf, Sharma, Gagan, Bivard, Andrew, Desmond, Patricia M, Yan, Bernard, Mitchell, Peter J, Thijs, Vincent, Carey, Leeanne, Meretoja, Atte, Davis, Stephen M, Donnan, Geoffrey A

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Early Active Mobilization during Mechanical Ventilation in the ICU von Hodgson, Carol L, Bailey, Michael, Bellomo, Rinaldo, Brickell, Kathy, Broadley, Tessa, Buhr, Heidi, Gabbe, Belinda J, Gould, Doug W, Harrold, Meg, Higgins, Alisa M, Hurford, Sally, Iwashyna, Theodore J, Serpa Neto, Ary, Nichol, Alistair D, Presneill, Jeffrey J, Schaller, Stefan J, Sivasuthan, Janani, Tipping, Claire J, Webb, Steven, Young, Paul J

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Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study von Knight, Stephen R, Holden, Karl A, Merson, Laura, Russell, Clark D, Solomon, Tom, Carson, Gail, Olliaro, Piero, Semple, Malcolm G, Alex, Beatrice, Bach, Benjamin, Dunning, Jake, da Silva Filipe, Ana, Horby, Peter W, Law, Andrew, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Scott, Janet T, de Silva, Thushan, Sigfrid, Louise, Tedder, Richard S, Thwaites, Ryan S, Turtle, Lance CW, Andrikopoulos, Petros, Liggi, Sonia, Sands, Caroline, Fairfield, Cameron J, Shaw, Catherine A, Dalton, Jo, Girvan, Michelle, Hendry, Ross, Greenhalf, William, McDonald, Sarah E, Booth, Laura, Catterall, Benjamin WA, Clarke, Emily A, Dincarslan, Oslem, Dyer, Philip, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L, Jones, Christopher B, Khandaker, Shadia, Lefteri, Daniella, Livoti, Lucia A, Middleton, Joanna, Reynolds, Will, Ridley, P. Matthew, Shaw, Victoria E, Tanianis-Hughes, Jolanta, Trochu, Erwan, Flaherty, Lisa, Massey, Hannah, Aldera, Erin L., Alegria, Ana, Barnass, Stella, Barrett, Nicholas, Basude, Sneha, Baxter, David, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cutino-Moguel, Maria-Teresa, Douthwaite, Sam, Fullerton, Duncan, Garg, Atul, Hawcutt, Daniel B, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Koduri, Gouri, Laird, Steven, Leiner, Tamas, Little, Jeff, McEwen, Ruth, Morris, Craig, Moses, Samuel, Norris, Lillian, Panchatsharam, Selva, Pattison, Natalie, Peters, Mark, Price, David, Prout, Rachel, Richardson, Neil, Rousseau, Guy, Ryan, Brendan, Sharma, Anil, Stambach, Tom, Stewart, Richard, Thompson, Robert, Tridente, Ascanio, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Wilson, Lawrence, Wiselka, Martin, Wootton, Daniel G, Workman, Andrew, Young, Peter

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Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort von Manuck, Tracy A., MD, Rice, Madeline Murguia, PhD, Bailit, Jennifer L., MD, MPH, Grobman, William A., MD, Reddy, Uma M., MD, MPH, Wapner, Ronald J., MD, Thorp, John M., MD, Caritis, Steve N., MD, Prasad, Mona, DO, MPH, Tita, Alan T.N., MD, PhD, Saade, George R., MD, Sorokin, Yoram, MD, Rouse, Dwight J., MD, Blackwell, Sean C., MD, Tolosa, Jorge E., MD

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Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WH... von Bloom, Chloe I, Drake, Thomas M, Lipworth, Brian J, Johnston, Sebastian L, Nguyen-Van-Tam, Jonathan S, Carson, Gail, Semple, Malcolm G, Cullinan, Paul, Openshaw, Peter J M, Bach, Benjamin, Barclay, Wendy S, Chand, Meera, Fletcher, Tom, Khoo, Saye, Meynert, Alison M, Price, Nicholas, Robertson, David L, Sancho-Shimizu, Vanessa, Thomson, Emma C, Hardwick, Hayley, Oosthuyzen, Wilna, Pius, Riinu, Knight, Stephen R, Shaw, Catherine A, Marsh, Laura, Clohisey, Sara, Hendry, Ross, Scott-Brown, James, Shaw, Victoria, McDonald, Sara, Ahmed, Katie A., Booth, Laura, Catterall, Benjamin WA, Clarke, Emily A, Cooper, Louise, Davis, Christopher, Dincarslan, Oslem, Dunn, Chris, Evans, Anthony, Khandaker, Shadia, Lant, Suzannah, Lett, Lauren, McDonald, Sarah, McLauchlan, John, Penrice-Randal, Rebekah, Pilgrim, Jack, Wilcock, Eve, Carracedo, Alejandra Doce, Carlucci, Nicola, Holmes, Anthony, Agranoff, Daniel, Atkinson, Dougal, Barnass, Stella, Bassford, Christopher, Baxter, David, Beadsworth, Michael, Bothma, Pieter, Brittain-Long, Robin, Chambler, Duncan, Child, Jenny, Cupitt, Jason, Dark, Paul, Douthwaite, Sam, Dushianthan, Ahilanadan, Fullerton, Duncan, Hawcutt, Daniel B, Hormis, Anil, Kaliappan, Agilan, Kasipandian, Vidya, Kegg, Stephen, Kerslake, Ian, Koch, Oliver, Koshy, George, Laha, Shondipon, Limb, James, MacMahon, Michael, Matovu, Elijah, McEwen, Ruth, Mok, Quen, Mortimore, Katherine, Mpenge, Mbiye, Pais, Mark, Pepperell, Justin, Phull, Mandeep, Post, Frank, Reschreiter, Henrik, Roberts, Mark, Roberts, Devender, Rose, Alistair, Ryan, Brendan, Spittle, Nick, Thompson, Robert, Vuylsteke, Alan, Waddy, Sam, Whittaker, Paul, Whittington, Ashley, Wijesinghe, Meme, Wilson, Sarah, Wooton, Daniel G, Yates, Bryan

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Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery von Devereaux, P J, Chan, Matthew T V, Alonso-Coello, Pablo, Walsh, Michael, Berwanger, Otavio, Villar, Juan Carlos, Wang, C Y, Garutti, R Ignacio, Jacka, Michael J, Sigamani, Alben, Srinathan, Sadeesh, Biccard, Bruce M, Chow, Clara K, Abraham, Valsa, Tiboni, Maria, Pettit, Shirley, Szczeklik, Wojciech, Lurati Buse, Giovanna, Botto, Fernando, Guyatt, Gordon, Heels-Ansdell, Diane, Sessler, Daniel I, Thorlund, Kristian, Garg, Amit X, Mrkobrada, Marko, Thomas, Sabu, Rodseth, Reitze N, Pearse, Rupert M, Thabane, Lehana, McQueen, Matthew J, VanHelder, Tomas, Bhandari, Mohit, Bosch, Jackie, Kurz, Andrea, Polanczyk, Carisi, Malaga, German, Nagele, Peter, Le Manach, Yannick, Leuwer, Martin, Yusuf, Salim

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Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, pr... von Fairfield, Cameron J, Drake, Thomas M, Sigfrid, Louise, Docherty, Annemarie B, Girvan, Michelle, Dunning, Jake, Openshaw, Peter J M, Openshaw, Peter JM, Bach, Benjamin, Chand, Meera, Harrison, Ewen M, Hiscox, Julian A, Law, Andrew, Merson, Laura, Moore, Shona C, Russell, Clark D, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Tedder, Richard S, Palmieri, Carlo, Knight, Stephen R, Shaw, Catherine A, Marsh, Laura, Shaw, Victoria, McDonald, Sarah E, Keating, Seán, Armstrong, Jane A, Ashworth, Milton, Booth, Laura, Brennan, Benjamin, Bullock, Katie, Cooper, Louise, Davis, Christopher, Dincarslan, Oslem, Dunn, Chris, Evans, Anthony, Garcia-Dorival, Isabel, Jones, Christopher B, Khandaker, Shadia, Lant, Suzannah, Lavelle-Langham, Lara, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A, Mancini, Maria, McLauchlan, John, Murphy, Ellen G, Penrice-Randal, Rebekah, Pilgrim, Jack, Small, Benjamin, Subramaniam, Krishanthi S, Tanianis-Hughes, Jolanta, van Tonder, Libby, Wilcock, Eve, Flaherty, Lisa, MacLean, Alan, Agranoff, Daniel, Aldera, Erin L., Alegria, Ana, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Basude, Sneha, Chadwick, David, Chee, Nigel, Chukkambotla, Srikanth, Cutino-Moguel, Maria-Teresa, Dark, Paul, Donnison, Phil, Douthwaite, Sam, Dushianthan, Ahilanadan, Eziefula, Chi, Fegan, Chrisopher, Garg, Atul, Hawcutt, Daniel B, Hobrok, Maria, Jennings, Paul, Koduri, Gouri, Laha, Shondipon, Laird, Steven, MacNaughton, Emily, Mankregod, Ravish, Masson, Huw, McCullough, Katherine, Mirfenderesky, Mariyam, Mohandas, Kavya, Morris, Craig, Nagel, Megan, Papakonstantino, Danai, Pintus, Stefania, Singh Pooni, Jagtur, Prout, Rachel, Roberts, Devender, Rose, Alistair, Shawcross, Anna, Tatham, Kate, Vuylsteke, Alan, Whittaker, Paul, Wiselka, Martin

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Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG) von Wang, Winfred C, Prof, Ware, Russell E, Prof, Miller, Scott T, Prof, Iyer, Rathi V, Prof, Casella, James F, Prof, Minniti, Caterina P, MD, Rana, Sohail, Prof, Thornburg, Courtney D, MD, Rogers, Zora R, Prof, Kalpatthi, Ram V, MD, Barredo, Julio C, Prof, Brown, R Clark, MD, Sarnaik, Sharada A, Prof, Howard, Thomas H, Prof, Wynn, Lynn W, MSN, Kutlar, Abdullah, Prof, Armstrong, F Daniel, Prof, Files, Beatrice A, MD, Goldsmith, Jonathan C, MD, Waclawiw, Myron A, PhD, Huang, Xiangke, MD, Thompson, Bruce W, PhD

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Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study von Sullivan, Michael K, Lees, Jennifer S, Drake, Thomas M, Docherty, Annemarie B, Oates, Georgia, Hardwick, Hayley E, Russell, Clark D, Merson, Laura, Dunning, Jake, Nguyen-Van-Tam, Jonathan S, Openshaw, Peter, Harrison, Ewen M, Baillie, J Kenneth, Semple, Malcolm G, Ho, Antonia, Mark, Patrick B

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Impact of autism genetic risk on brain connectivity: a mechanism for the female protective effect von Lawrence, Katherine E, Hernandez, Leanna M, Fuster, Emily, Padgaonkar, Namita T, Patterson, Genevieve, Jung, Jiwon, Okada, Nana J, Lowe, Jennifer K, Hoekstra, Jackson N, Jack, Allison, Aylward, Elizabeth, Gaab, Nadine, Van Horn, John D, Bernier, Raphael A, McPartland, James C, Webb, Sara J, Pelphrey, Kevin A, Green, Shulamite A, Bookheimer, Susan Y, Geschwind, Daniel H, Dapretto, Mirella

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Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK von Docherty, Annemarie B, Hardwick, Hayley E, Harrison, Janet, Ho, Antonia, Hughes, David M, Keogh, Ruth H, Russell, Clark D, Tom, Brian DM, Harrison, Ewen M, Semple, Malcolm G, Semple, Malcolm G, Carson, Gail, Alex, Beatrice, Bogaert, Debby, da Silva Filipe, Ana, Fletcher, Tom, Green, Christopher A, Ijaz, Samreen, Khoo, Say, Law, Andrew, Lim, Wei Shen, Meynert, Alison M, Paxton, William A, Robertson, David L, Summers, Charlotte, Turtle, Lance CW, Gupta, Rishi K, Oosthuyzen, Wilna, Norman, Lisa, Drake, Thomas M, Mclean, Kenneth A, Roberts, Stephanie, Connor, Marie, Leeming, Gary, Scott-Brown, James, Ahmed, Katie A, Asiimwe, Innocent G, Barlow, Samantha L, Brennan, Benjamin, Cox, Helen, Dunn, Chris, Elliott, Angela, Finch, Lorna, Jones, Trevor R, Kiy, Robyn T, McEvoy, Laurence, Miah, Nahida S, Prince, Tessa, Small, Benjamin, Szemiel, Agnieska, Taggart, Aislynn, Trochu, Erwan, Wilcock, Eve, Doce Carracedo, Alejandra, Agwuh, Ken, Angus, Brian, Barrett, Nicholas, Bernatoniene, Jolanta, Berridge, John, Burtenshaw, Andrew, Caruth, Vikki, Child, Jenny, Clark, Tom, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Gkrania-Klotsas, Effrossyni, Godden, Jo, Goldsmith, Arthur, Hardy, Elaine, Harvey, Daniel, Hodgson, Luke, Jacobs, Michael, Kegg, Stephen, Kendall, Jason, Linnett, Vanessa, MacMahon, Michael, MacNaughton, Emily, McEwen, Ruth, Mills, Gary, Moore, Elinoor, Moses, Samuel, Nelson, Mark, O'Shea, Matthew K, Pais, Mark, Peters, Mark, Rousseau, Guy, Saluja, Taranprit, Shanmuga, Prad, Shankar-Hari, Manu, Smith, Richard, Snelson, Catherine, Tridente, Ascanio, Visuvanathan, Shico, Walden, Andrew, Whittaker, Paul, Whittington, Ashley, Williams, Martin, Wolverson, Adam, Young, Peter

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