HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B von Kirouac, Daniel C, Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D, Nielsen, Ulrik B, Schoeberl, Birgit, McDonagh, Charlotte F

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Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas von Gerber, Hans-Peter, Kung-Sutherland, May, Stone, Ivan, Morris-Tilden, Carol, Miyamoto, Jamie, McCormick, Renee, Alley, Stephen C., Okeley, Nicole, Hayes, Brad, Hernandez-Ilizaliturri, Francisco J., McDonagh, Charlotte F., Carter, Paul J., Benjamin, Dennis, Grewal, Iqbal S.

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Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70 von MCEARCHERN, Julie A, SMITH, Leia M, GREWAL, Iqbal S, LAW, Che-Leung, MCDONAGH, Charlotte F, KLUSSMAN, Kerry, GORDON, Kristine A, MORRIS-TILDEN, Carol A, DUNIHO, Steven, RYAN, Maureen, BOURSALIAN, Tamar E, CARTER, Paul J

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Antibody targeting of B-cell maturation antigen on malignant plasma cells von Ryan, Maureen C, Hering, Michelle, Peckham, David, McDonagh, Charlotte F, Brown, Lindsay, Kim, Kristine M, Meyer, Damon L, Zabinski, Roger F, Grewal, Iqbal S, Carter, Paul J

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Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index von McDonagh, Charlotte F, Kim, Kristine M, Turcott, Eileen, Brown, Lindsay L, Westendorf, Lori, Feist, Tiffany, Sussman, Django, Stone, Ivan, Anderson, Martha, Miyamoto, Jamie, Lyon, Robert, Alley, Stephen C, Gerber, Hans-Peter, Carter, Paul J

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Anti-CD30 diabody-drug conjugates with potent antitumor activity von Kim, Kristine M, McDonagh, Charlotte F, Westendorf, Lori, Brown, Lindsay L, Sussman, Django, Feist, Tiffany, Lyon, Robert, Alley, Stephen C, Okeley, Nicole M, Zhang, Xinqun, Thompson, Melissa C, Stone, Ivan, Gerber, Hans-Peter, Carter, Paul J

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Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3 von McDonagh, Charlotte F, Huhalov, Alexandra, Harms, Brian D, Adams, Sharlene, Paragas, Violette, Oyama, Shinji, Zhang, Bo, Luus, Lia, Overland, Ryan, Nguyen, Stephanie, Gu, Jinming, Kohli, Neeraj, Wallace, Matt, Feldhaus, Michael J, Kudla, Arthur J, Schoeberl, Birgit, Nielsen, Ulrik B

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Computational modeling of ERBB2-amplified breast cancer identifies combined ErbB2/3 blockade as superior to the combination of MEK and AKT inhibitors von Kirouac, Daniel C, Du, Jin Y, Lahdenranta, Johanna, Overland, Ryan, Yarar, Defne, Paragas, Violette, Pace, Emily, McDonagh, Charlotte F, Nielsen, Ulrik B, Onsum, Matthew D

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Single-Cell Quantitative HER2 Measurement Identifies Heterogeneity and Distinct Subgroups within Traditionally Defined HER2-Positive Patients von Onsum, Matthew D, Geretti, Elena, Paragas, Violette, Kudla, Arthur J, Moulis, Sharon P, Luus, Lia, Wickham, Thomas J, McDonagh, Charlotte F, MacBeath, Gavin, Hendriks, Bart S

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Engineered antibody–drug conjugates with defined sites and stoichiometries of drug attachment von McDonagh, Charlotte F., Turcott, Eileen, Westendorf, Lori, Webster, Jennifer B., Alley, Stephen C., Kim, Kristine, Andreyka, Jamie, Stone, Ivan, Hamblett, Kevin J., Francisco, Joseph A., Carter, Paul

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Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities von McEarchern, Julie A., Oflazoglu, Ezogelin, Francisco, Leigh, McDonagh, Charlotte F., Gordon, Kristine A., Stone, Ivan, Klussman, Kerry, Turcott, Eileen, van Rooijen, Nico, Carter, Paul, Grewal, Iqbal S., Wahl, Alan F., Law, Che-Leung

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Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Ce... von Chu, S. Haihua, Budak, Elizabeth, Mondal, Nandini, Zhang, Kathy, Harmon, Alexander, Wong, Jeffrey, Lam, Dieter, Lucini, Corrina, Coisman, Brent, Qiao, Kangjian, Bai, Tao, Decker, Jeremy, Gantzer, Bob, Lee, Kindo, Sen, Maya, Bohnuud, Tanggis, Barrera, Luis, Cafferty, Brian, Lee, Seung-Joo, Kopesky, Paul, Gaudelli, Nicole M., McDonagh, Charlotte F, Ciaramella, Giuseppe, Hartigan, Adam J.

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Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem C... von Mondal, Nandini, Harmon, Alexander, Budak, Elizabeth, Zhang, Kathy, Wong, Jeffrey, Rinaldi, Conrad, Olins, Jenny, Hoar, Kara, Menon, Archita Venugopal, White, Moriah, Musenge, Faith, Camblin, Adam, Wolin, Adam, Coisman, Brent, Bai, Tao, Qiao, Kangjian, Patel, Mudra, Decker, Jeremy, Gantzer, Bob, Leete, Thomas, Yu, Yi, Bohnuud, Tanggis, Lee, Seung-Joo, Smith, Sarah, McDonagh, Charlotte F, Gaudelli, Nicole M., Chu, S. Haihua, Hartigan, Adam J., Ciaramella, Giuseppe

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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning... von Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model von Hyzy, Sharon L., Proctor, Jennifer L, Gillard, Geoff O, Hammond, Katelyn J., Sarma, Ganapathy N., Saha, Asim, Clark, Nicholas, Bhat, Anjali, Lamothe, Tahirih L, Palchaudhuri, Rahul, Pearse, Bradley R, McDonagh, Charlotte F, Kiem, Hans-Peter, Wagner, John E, Blazar, Bruce R., Boitano, Anthony E, Cooke, Michael P, Davis, John C.

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Improved Yield and Stability of L49-sFv−β-Lactamase, a Single-Chain Antibody Fusion Protein for Anticancer Prodrug Activation, by Protein Engineering von McDonagh, Charlotte F, Beam, Kevin S, Wu, Gabrielle J. S, Chen, Judy H, Chace, Dana F, Senter, Peter D, Francisco, Joseph A

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Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models von Palchaudhuri, Rahul, Hyzy, Sharon L., Proctor, Jennifer L, Adams, Hillary L, Pearse, Bradley R, Sarma, Ganapathy, Aslanian, Sharon, Gillard, Geoff, Lamothe, Tahirih L, Burenkova, Olga, Brooks, Melissa L., Gabros, Andrew D, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates von Tisdale, John F., Donahue, Robert E., Uchida, Naoya, Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Krouse, Allen, Linde, Nathaniel S., Bonifacino, Aylin C., Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L, Hyzy, Sharon L., Adams, Hillary L, Brooks, Melissa L., Gabros, Andrew D, McDonough, Sean M, Kien, Lena, Aslanian, Sharon, Pearse, Bradley R, Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sarma, Ganapathy, McShea, Molly A, Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Tran... von Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Panwar, Rajiv, Sarma, Ganapathy, McShea, Molly A, Kien, Lena, Dushime, Junia, Adams, Hillary L, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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