Tumor suppressor p53: from engaging DNA to target gene regulation von Sammons, Morgan A., Nguyen, Thuy-Ai T., McDade, Simon S., Fischer, Martin

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Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer von Garcia-Alonso, Luz, Iorio, Francesco, Matchan, Angela, Fonseca, Nuno, Jaaks, Patricia, Peat, Gareth, Pignatelli, Miguel, Falcone, Fiammetta, Benes, Cyril H, Dunham, Ian, Bignell, Graham, McDade, Simon S, Garnett, Mathew J, Saez-Rodriguez, Julio

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Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability von Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul

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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells von Woznicki, Jerzy A., Saini, Nisha, Flood, Peter, Rajaram, Subhasree, Lee, Ciaran M., Stamou, Panagiota, Skowyra, Agnieszka, Bustamante-Garrido, Milan, Regazzoni, Karine, Crawford, Nyree, McDade, Simon S., Longley, Daniel B., Aza-Blanc, Pedro, Shanahan, Fergus, Zulquernain, Syed A., McCarthy, Jane, Melgar, Silvia, McRae, Bradford L., Nally, Ken

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ClassifieR 2.0: expanding interactive gene expression-based stratification to prostate and high-grade serous ovarian cancer von McCabe, Aideen, Quinn, Gerard P, Jain, Suneil, Ó Dálaigh, Micheál, Dean, Kellie, Murphy, Ross G, McDade, Simon S

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Dissecting the DNA binding landscape and gene regulatory network of p63 and p53 von Riege, Konstantin, Kretzmer, Helene, Sahm, Arne, McDade, Simon S., Hoffmann, Steve, Fischer, Martin

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Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification von Dunne, Philip D., Alderdice, Matthew, O'Reilly, Paul G., Roddy, Aideen C., McCorry, Amy M. B., Richman, Susan, Maughan, Tim, McDade, Simon S., Johnston, Patrick G., Longley, Daniel B., Kay, Elaine, McArt, Darragh G., Lawler, Mark

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Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil von Chatterjee, Susanta, Naeli, Parisa, Onar, Okan, Simms, Nicole, Garzia, Aitor, Hackett, Angela, Coyle, Kelsey, Harris Snell, Patric, McGirr, Tom, Sawant, Tanvi Nitin, Dang, Kexin, Stoichkova, Zornitsa Vasileva, Azam, Yumna, Saunders, Mark P, Braun, Michael, Alain, Tommy, Tuschl, Thomas, McDade, Simon S, Longley, Daniel B, Gkogkas, Christos G, Adrain, Colin, Knight, John R P, Jafarnejad, Seyed Mehdi

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surviveR: a flexible shiny application for patient survival analysis von Sessler, Tamas, Quinn, Gerard P., Wappett, Mark, Rogan, Emily, Sharkey, David, Ahmaderaghi, Baharak, Lawler, Mark, Longley, Daniel B., McDade, Simon S.

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classifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes von Quinn, Gerard P, Sessler, Tamas, Ahmaderaghi, Baharak, Lambe, Shauna, VanSteenhouse, Harper, Lawler, Mark, Wappett, Mark, Seligmann, Bruce, Longley, Daniel B, McDade, Simon S

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BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability von SAVAGE, Kienan I, MATCHETT, Kyle B, POWELL, Alexander, MANTI, Lorenzo, MCDADE, Simon S, BEN HO PARK, PRISE, Kevin M, MCINTOSH, Stuart A, SALTO-TELLEZ, Manuel, RICHARD, Derek J, ELLIOTT, Christopher T, HARKIN, D. Paul, BARROS, Eliana M, COOPER, Kevin M, IRWIN, Gareth W, GORSKI, Julia J, ORR, Katy S, VOHHODINA, Jekaterina, KAVANAGH, Joy N, MADDEN, Angelina F

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Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML von Smith, James S., Lappin, Katrina M., Craig, Stephanie G., Liberante, Fabio G., Crean, Clare M., McDade, Simon S., Thompson, Alexander, Mills, Ken I., Savage, Kienan I.

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Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes von HYLAND, Paula L, MCDADE, Simon S, MCCLOSKEY, Rachel, DICKSON, Glenda J, ARTHUR, Ken, MCCANCE, Dennis J, PATEL, Daksha

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Comparison of Molecular Assays for HPV Testing in Oropharyngeal Squamous Cell Carcinomas: A Population-Based Study in Northern Ireland von Craig, Stephanie G., Anderson, Lesley A., Moran, Michael, Graham, Laura, Currie, Keith, Rooney, Keith, Robinson, Max, Bingham, Victoria, Cuschieri, Kate S., McQuaid, Stephen, Schache, Andrew G., Jones, Terry M., McCance, Dennis, Salto-Tellez, Manuel, McDade, Simon S., James, Jacqueline A.

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Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells von Steiner, Ivana, Flores-Tellez, Teresita del N.J., Mevel, Renaud, Ali, Amin, Wang, Pengbo, Schofield, Pieta, Behan, Caron, Forsythe, Nicholas, Ashton, Garry, Taylor, Catherine, Mills, Ian G., Oliveira, Pedro, McDade, Simon S., Zaiss, Dietmar M., Choudhury, Ananya, Lacaud, Georges, Baena, Esther

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Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer von Haughey, Charles M., Mukherjee, Debayan, Steele, Rebecca E., Popple, Amy, Dura-Perez, Lara, Pickard, Adam, Patel, Mehjabin, Jain, Suneil, Mullan, Paul B., Williams, Rich, Oliveira, Pedro, Buckley, Niamh E., Honeychurch, Jamie, McDade, Simon S., Illidge, Timothy, Mills, Ian G., Eddie, Sharon L.

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MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of p53 Levels by E6 von MCKENNA, Declan J, MCDADE, Simon S, PATEL, Daksha, MCCANCE, Dennis J

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Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data von Ahmaderaghi, Baharak, Amirkhah, Raheleh, Jackson, James, Lannagan, Tamsin R M, Gilroy, Kathryn, Malla, Sudhir B, Redmond, Keara L, Quinn, Gerard, McDade, Simon S, ACRCelerate Consortium, Maughan, Tim, Leedham, Simon, Campbell, Andrew S D, Sansom, Owen J, Lawler, Mark, Dunne, Philip D

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A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence von Brien, Gerard L, Healy, Evan, Jerman, Emilia, Conway, Eric, Fadda, Elisa, O'Donovan, Darragh, Krivtsov, Andrei V, Rice, Alan M, Kearney, Conor J, Flaus, Andrew, McDade, Simon S, Martin, Seamus J, McLysaght, Aoife, O'Connell, David J, Armstrong, Scott A, Bracken, Adrian P

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HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures von Pickard, Adam, McDade, Simon S, McFarland, Marie, McCluggage, W Glenn, Wheeler, Cosette M, McCance, Dennis J

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