Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion von Briggs, Emma, Crouch, Kathryn, Lemgruber, Leandro, Lapsley, Craig, McCulloch, Richard

Volltext

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing von Briggs, Emma M., Rojas, Federico, McCulloch, Richard, Matthews, Keith R., Otto, Thomas D.

Volltext

Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes von Kieft, Rudo, Zhang, Yang, Marand, Alexandre P., Moran, Jose Dagoberto, Bridger, Robert, Wells, Lance, Schmitz, Robert J., Sabatini, Robert

Volltext

DNA damage and oxidative stress in human cells infected by Trypanosoma cruzi von Florentino, Pilar T., Mendes, Davi, Vitorino, Francisca Nathalia L., Martins, Davi J., Cunha, Julia P. C., Mortara, Renato A., Menck, Carlos F. M.

Volltext

DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in Leishmania donovani and the Cdc45 PIP box is essential for cell survival von Yadav, Aarti, Sharma, Varshni, Pal, Jyoti, Gulati, Pallavi, Goel, Manisha, Chandra, Udita, Bansal, Neha, Saha, Swati

Volltext

Conservation and Variation in Strategies for DNA Replication of Kinetoplastid Nuclear Genomes von Marques, Catarina A, McCulloch, Richard

Volltext

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication von Damasceno, Jeziel D, Reis-Cunha, João, Crouch, Kathryn, Beraldi, Dario, Lapsley, Craig, Tosi, Luiz R O, Bartholomeu, Daniella, McCulloch, Richard

Volltext

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei von Stortz, Jennifer A, Serafim, Tiago D, Alsford, Sam, Wilkes, Jonathan, Fernandez-Cortes, Fernando, Hamilton, Graham, Briggs, Emma, Lemgruber, Leandro, Horn, David, Mottram, Jeremy C, McCulloch, Richard

Volltext

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes von da Silva, Marcelo Santos, Hovel-Miner, Galadriel A, Briggs, Emma M, Elias, Maria Carolina, McCulloch, Richard

Volltext

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response von Li, Guang-Yao, McCulloch, Richard D., Fenton, Amanda L., Cheung, Melissa, Meng, Li, Ikura, Mitsuhiko, Koch, C. Anne, Wright, Peter E.

Volltext

Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes von Nenarokova, Anna, Záhonová, Kristína, Krasilnikova, Marija, Gahura, Ondřej, McCulloch, Richard, Zíková, Alena, Yurchenko, Vyacheslav, Lukeš, Julius

Volltext

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens von Black, Jennifer Ann, Crouch, Kathryn, Lemgruber, Leandro, Lapsley, Craig, Dickens, Nicholas, Tosi, Luiz R.O., Mottram, Jeremy C., McCulloch, Richard

Volltext

RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse von Fernandez-Cortes, Fernando, Serafim, Tiago D., Wilkes, Jonathan M., Jones, Nathaniel G., Ritchie, Ryan, McCulloch, Richard, Mottram, Jeremy C.

Volltext

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections von Jayaraman, Siddharth, Harris, Claire, Paxton, Edith, Donachie, Anne-Marie, Vaikkinen, Heli, McCulloch, Richard, Hall, James P J, Kenny, John, Lenzi, Luca, Hertz-Fowler, Christiane, Cobbold, Christina, Reeve, Richard, Michoel, Tom, Morrison, Liam J

Volltext

Replication origin location might contribute to genetic variability in Trypanosoma cruzi von de Araujo, Christiane Bezerra, Chagas da Cunha, Julia Pinheiro, Inada, Davi Toshio, Damasceno, Jeziel, Jeronimo Lima, Alex Ranieri, Hiraiwa, Priscila, Marques, Catarina, Goncalves, Evonnildo, Nishiyama-Junior, Milton Yutaka, McCulloch, Richard, Elias, Maria Carolina

Volltext

Genome-wide Analysis Reveals Extensive Functional Interaction between DNA Replication Initiation and Transcription in the Genome of Trypanosoma brucei von Tiengwe, Calvin, Marcello, Lucio, Farr, Helen, Dickens, Nicholas, Kelly, Steven, Swiderski, Michal, Vaughan, Diane, Gull, Keith, Barry, J. David, Bell, Stephen D., McCulloch, Richard

Volltext

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation von Devlin, Rebecca, Marques, Catarina A, Paape, Daniel, Prorocic, Marko, Zurita-Leal, Andrea C, Campbell, Samantha J, Lapsley, Craig, Dickens, Nicholas, McCulloch, Richard

Volltext

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication von Damasceno, Jeziel Dener, Marques, Catarina A., Beraldi, Dario, Crouch, Kathryn, Lapsley, Craig, Obonaga, Ricardo, Tosi, Luiz R. O., McCulloch, Richard

Volltext

DNA Recombination Strategies During Antigenic Variation in the African Trypanosome von McCulloch, Richard, Morrison, Liam J, Hall, James P J

Volltext

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation von Macrae, Chloe J., McCulloch, Richard D., Ylanko, Jarkko, Durocher, Daniel, Koch, C. Anne

Volltext