Biostructural, biochemical and biophysical studies of mutant IDH1 von McCoy, Mark A., Lu, Jun, Richard Miller, F., Soisson, Stephen M., Lam, Michael H., Fischer, Christian

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Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry von Rizvi, Noreen F, Howe, John A, Nahvi, Ali, Klein, Daniel J, Fischmann, Thierry O, Kim, Hai-Young, McCoy, Mark A, Walker, Scott S, Hruza, Alan, Richards, Matthew P, Chamberlin, Chad, Saradjian, Peter, Butko, Margaret T, Mercado, Gabriel, Burchard, Julja, Strickland, Corey, Dandliker, Peter J, Smith, Graham F, Nickbarg, Elliott B

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Investigating protein-excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy von Panchal, Jainik, Falk, Bradley T, Antochshuk, Valentyn, McCoy, Mark A

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Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments von Ban, David, Rice, Cory T, McCoy, Mark A

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Insulin purification—Innovation continuum via synthesis of fundamentals, technology, and modeling von Roush, David, Iammarino, Michael, Chmielowski, Rebecca, Insaidoo, Francis, McCoy, Mark A., Ortigosa, Allison, Rauscher, Michael

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High-Throughput Fluorometric Assay For Quantifying Polysorbate In Biopharmaceutical Products Using Micelle Activated Fluorescence Probe N-Phenyl-1-Naphthylamine von Dow, Ximeng Y., Gao, Qi, Sperduto, John L., Wen, Xiaona, Thai, Christopher, Zhang, Lei, McCoy, Mark A.

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Diffusion Profiling of Therapeutic Proteins by Using Solution NMR Spectroscopy von Falk, Bradley T., Liang, Yingkai, McCoy, Mark A.

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Investigating protein-excipient interactions of a multivalent V HH therapeutic protein using NMR spectroscopy von Panchal, Jainik, Falk, Bradley T, Antochshuk, Valentyn, McCoy, Mark A

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Spatial Localization of Ligand Binding Sites from Electron Current Density Surfaces Calculated from NMR Chemical Shift Perturbations von McCoy, Mark A, Wyss, Daniel F

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Profiling Insulin Oligomeric States by 1H NMR Spectroscopy for Formulation Development of Ultra-Rapid-Acting Insulin von Falk, Bradley T., Liang, Yingkai, McCoy, Mark A.

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Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α von Tawa, Paul, Zhang, Lei, Metwally, Essam, Hou, Yan, McCoy, Mark A., Seganish, W. Michael, Zhang, Rumin, Frank, Emily, Sheth, Payal, Hanisak, Jennifer, Sondey, Christopher, Bauman, David, Soriano, Aileen

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NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes von Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.

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Identification of preferred multimodal ligand‐binding regions on IgG1 FC using nuclear magnetic resonance and molecular dynamics simulations von Gudhka, Ronak B., Bilodeau, Camille L., McCallum, Scott A., McCoy, Mark A., Roush, David J., Snyder, Mark A., Cramer, Steven M.

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Probing IgG1 FC–Multimodal Nanoparticle Interactions: A Combined Nuclear Magnetic Resonance and Molecular Dynamics Simulations Approach von Gudhka, Ronak B, Vats, Mayank, Bilodeau, Camille L, McCallum, Scott A, McCoy, Mark A, Roush, David J, Snyder, Mark A, Cramer, Steven M

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Flexible Lid to the p53-Binding Domain of Human Mdm2: Implications for p53 Regulation von McCoy, Mark A., Gesell, Jennifer J., Senior, Mary M., Wyss, Daniel F.

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Structures of Protein−Protein Complexes Are Docked Using Only NMR Restraints from Residual Dipolar Coupling and Chemical Shift Perturbations von McCoy, Mark A, Wyss, Daniel F

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NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions von Falk, Bradley T., Liang, Yingkai, Bailly, Marc, Raoufi, Fahimeh, Kekec, Ahmet, Pissarnitski, Dmitri, Feng, Dennis, Yan, Lin, Lin, Songnian, Fayadat‐Dilman, Laurence, McCoy, Mark A.

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Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index von Pissarnitski, Dmitri A, Kekec, Ahmet, Yan, Lin, Zhu, Yuping, Feng, Danqing D, Huo, Pei, Madsen-Duggan, Christina, Moyes, Christopher R, Nargund, Ravi P, Kelly, Terri, Zhang, Xiaoping, Carballo-Jane, Ester, Gorski, Judith, Zafian, Peter, Qatanani, Mo, Kaarsholm, Niels, Meng, Fanyu, Jia, Xiujuan, Lee, Keun-Joong, Wang, Weixun, Xu, Sherrie, Hohn, Michael J, Iammarino, Michael J, McCoy, Mark A, Okoh, Grace A, Liang, Yingkai, Hollingsworth, Scott A, Erion, Mark D, Kelley, David E, Garbaccio, Robert M, Zhang, Amy, Mu, James, Lin, Songnian

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Identification of preferred multimodal ligand-binding regions on IgG1 F C using nuclear magnetic resonance and molecular dynamics simulations von Gudhka, Ronak B, Bilodeau, Camille L, McCallum, Scott A, McCoy, Mark A, Roush, David J, Snyder, Mark A, Cramer, Steven M

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Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab von Hutchins, Beth, Starling, Gary C, McCoy, Mark A, Herzyk, Danuta, Poulet, Frederique M, Dulos, John, Liu, Liming, Kang, Soonmo Peter, Fayadat-Dilman, Laurence, Hsieh, Mark, Andrews, Christine L, Ayanoglu, Gulesi, Cullen, Constance, Malefyt, Rene de Waal, Kastelein, Robert A, Saux, Sabine Le, Lee, Julie, Li, Sophie, Malashock, Dan, Sadekova, Svetlana, Soder, George, van Eenennaam, Hans, Willingham, Aarron, Yu, Ying, Streuli, Michel, Carven, Gregory J, van Elsas, Andrea

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