Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbo... von Fensome, Andrew, Adams, William R, Adams, Andrea L, Berrodin, Tom J, Cohen, Jeff, Huselton, Christine, Illenberger, Arthur, Kern, Jeffrey C, Hudak, Valerie A, Marella, Michael A, Melenski, Edward G, McComas, Casey C, Mugford, Cheryl A, Slayden, Ov D, Yudt, Matthew, Zhang, Zhiming, Zhang, Puwen, Zhu, Yuan, Winneker, Richard C, Wrobel, Jay E

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Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Partitioning the Loss in Vancomycin Binding Affinity for d-Ala-d-Lac into Lost H-Bond and Repulsive Lone Pair Contributions von McComas, Casey C, Crowley, Brendan M, Boger, Dale L

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Front Cover: Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 (ChemMedChem 17/2017) von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Facile functionalization at the C2 position of a highly substituted benzofuran von He, Shuwen, Li, Peng, Dai, Xing, McComas, Casey C., Du, Chunyan, Wang, Ping, Lai, Zhong, Liu, Hong, Yin, Jingjun, Bulger, Paul G., Dang, Qun, Xiao, Dong, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan

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A general approach to substituted 6H-pyrido[2′,3′:5,6] [1,3]oxazino[3,4-a]indole via cyclization from an indoline precursor followed by re-aromatization von He, Shuwen, Li, Peng, Dai, Xing, McComas, Casey C., Huang, Hongling, Zhan, Chaoliang, Chang, Liang, Liu, Yuehui, Chen, Shaojun, Lai, Zhong, Liu, Hong, Yin, Jingjun, Dang, Qun, Xiao, Dong, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan

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Total Synthesis of the Ristocetin Aglycon von Crowley, Brendan M, Mori, Yoshiki, McComas, Casey C, Tang, Datong, Boger, Dale L

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A general approach to access 5,6-dihydroindolo-naphthyridine ring system von He, Shuwen, Li, Peng, Dai, Xing, Liu, Hong, Lai, Zhong, Xiao, Dong, McComas, Casey C., Du, Chunyan, Liu, Yuehui, Yin, Jingjun, Dang, Qun, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan

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A new generation of progesterone receptor modulators von Winneker, Richard C., Fensome, Andrew, Zhang, Puwen, Yudt, Matthew R., McComas, Casey C., Unwalla, Rayomond J.

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Discovery of Novel Selective Norepinephrine Reuptake Inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231) von O’Neill, David J, Adedoyin, Adedayo, Alfinito, Peter D, Bray, Jenifer A, Cosmi, Scott, Deecher, Darlene C, Fensome, Andrew, Harrison, Jim, Leventhal, Liza, Mann, Charles, McComas, Casey C, Sullivan, Nicole R, Spangler, Taylor B, Uveges, Albert J, Trybulski, Eugene J, Whiteside, Garth T, Zhang, Puwen

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Structure–activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores von Fensome, Andrew, Goldberg, Joel, McComas, Casey C., Trybulski, Eugene J., Woodworth, Richard P., Deecher, Darlene C., Whiteside, Garth T., Zhang, Puwen

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Synthesis and activity of novel 1-or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors von PUWEN ZHANG, TEREFENKO, Eugene A, MCCOMAS, Casey C, MAHANEY, Paige E, AN VU, TRYBULSKI, Eugene, KOURY, Elizabeth, JOHNSTON, Grace, BRAY, Jenifer, DEECHER, Darlene

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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines von Mahaney, Paige E., Vu, An T., McComas, Casey C., Zhang, Puwen, Nogle, Lisa M., Watts, William L., Sarkahian, Ani, Leventhal, Liza, Sullivan, Nicole R., Uveges, Albert J., Trybulski, Eugene J.

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Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters von McComas, Casey C., Crowley, Brendan M., Hwang, Inkyu, Boger, Dale L.

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Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: A new class of selective norepinephrine reuptake inhibitors von McComas, Casey C., Vu, An T., Mahaney, Paige E., Cohn, Stephen T., Fensome, Andrew, Marella, Michael A., Nogle, Lisa, Trybulski, Eugene J., Ye, Fei, Zhang, Puwen, Alfinito, Peter, Bray, Jenifer, Johnston, Grace, Koury, Elizabeth, Deecher, Darlene C.

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Synthesis of (±)-Madindolines and Chemical Models. Studies of Chemical Reactivity von McComas, Casey C, Perales, Joe B, Van Vranken, David L

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CYT01B, a Novel RAD51 Inhibitor, Act Synergistically with Both Targeted and Chemotherapeutic Anti-Cancer Agents von Maclay, Tyler, Vacca, Joseph, McComas, Casey, Castro, Alfredo, Day, Melinda, Mills, Kevin

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Large-Scale Synthesis of a Selective Inhibitor of the Norepinephrine Transporter: Mechanistic Aspects of Conversion of Indolinone Diol to Indolinone Aminoalcohol and Process Implic... von Alimardanov, Asaf, Gontcharov, Alexander, Nikitenko, Antonia, Chan, Anita W, Ding, Zhixian, Ghosh, Mousumi, Levent, Mahmut, Raveendranath, Panolil, Ren, Jianxin, Zhou, Maotang, Mahaney, Paige E, McComas, Casey C, Ashcroft, Joseph, Potoski, John R

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1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: Potent, Selective, and Orally Efficacious Norepinephrine Reuptake Inhibitors von Zhang, Puwen, Terefenko, Eugene A., Bray, Jenifer, Deecher, Darlene, Fensome, Andrew, Harrison, Jim, Kim, Callain, Koury, Elizabeth, Mark, Lilly, McComas, Casey C., Mugford, Cheryl A., Trybulski, Eugene J., Vu, An T., Whiteside, Garth T., Mahaney, Paige E.

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A Novel RAD51 Inhibitor, CYT01B, Shows Anti-Cancer Activity in Preclinical Models of Aid Expressing Lymphomas von Hasham, Muneer G, Patrick, Darryl, Bedard, Leanne, Vacca, Joseph, McComas, Casey, Castro, Alfredo, Day, Melinda, Mills, Kevin

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