Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbo... von Fensome, Andrew, Adams, William R, Adams, Andrea L, Berrodin, Tom J, Cohen, Jeff, Huselton, Christine, Illenberger, Arthur, Kern, Jeffrey C, Hudak, Valerie A, Marella, Michael A, Melenski, Edward G, McComas, Casey C, Mugford, Cheryl A, Slayden, Ov D, Yudt, Matthew, Zhang, Zhiming, Zhang, Puwen, Zhu, Yuan, Winneker, Richard C, Wrobel, Jay E

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Partitioning the Loss in Vancomycin Binding Affinity for d-Ala-d-Lac into Lost H-Bond and Repulsive Lone Pair Contributions von McComas, Casey C, Crowley, Brendan M, Boger, Dale L

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Total Synthesis of the Ristocetin Aglycon von Crowley, Brendan M, Mori, Yoshiki, McComas, Casey C, Tang, Datong, Boger, Dale L

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A general approach to access 5,6-dihydroindolo-naphthyridine ring system von He, Shuwen, Li, Peng, Dai, Xing, Liu, Hong, Lai, Zhong, Xiao, Dong, McComas, Casey C., Du, Chunyan, Liu, Yuehui, Yin, Jingjun, Dang, Qun, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan

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A new generation of progesterone receptor modulators von Winneker, Richard C., Fensome, Andrew, Zhang, Puwen, Yudt, Matthew R., McComas, Casey C., Unwalla, Rayomond J.

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Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters von McComas, Casey C., Crowley, Brendan M., Hwang, Inkyu, Boger, Dale L.

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Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Synthesis of (±)-Madindolines and Chemical Models. Studies of Chemical Reactivity von McComas, Casey C, Perales, Joe B, Van Vranken, David L

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Front Cover: Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 (ChemMedChem 17/2017) von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Facile functionalization at the C2 position of a highly substituted benzofuran von He, Shuwen, Li, Peng, Dai, Xing, McComas, Casey C., Du, Chunyan, Wang, Ping, Lai, Zhong, Liu, Hong, Yin, Jingjun, Bulger, Paul G., Dang, Qun, Xiao, Dong, Zorn, Nicolas, Peng, Xuanjia, Nargund, Ravi P., Palani, Anandan

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A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin von Wanner, Jutta, Tang, Datong, McComas, Casey C, Crowley, Brendan M, Jiang, Wanlong, Moss, Jason, Boger, Dale L

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Characterization of a Novel Biocatalyst System for Sulfide Oxidation von McComas, Charles, Sublette, Kerry L., Jenneman, Gary, Bala, Greg

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Discovery of Novel Selective Norepinephrine Reuptake Inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231) von O’Neill, David J, Adedoyin, Adedayo, Alfinito, Peter D, Bray, Jenifer A, Cosmi, Scott, Deecher, Darlene C, Fensome, Andrew, Harrison, Jim, Leventhal, Liza, Mann, Charles, McComas, Casey C, Sullivan, Nicole R, Spangler, Taylor B, Uveges, Albert J, Trybulski, Eugene J, Whiteside, Garth T, Zhang, Puwen

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Structure–activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores von Fensome, Andrew, Goldberg, Joel, McComas, Casey C., Trybulski, Eugene J., Woodworth, Richard P., Deecher, Darlene C., Whiteside, Garth T., Zhang, Puwen

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Synthesis and activity of novel 1-or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors von PUWEN ZHANG, TEREFENKO, Eugene A, MCCOMAS, Casey C, MAHANEY, Paige E, AN VU, TRYBULSKI, Eugene, KOURY, Elizabeth, JOHNSTON, Grace, BRAY, Jenifer, DEECHER, Darlene

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Dianions and Tetraanions of Bowl-Shaped Fullerene Fragments Dibenzo[a,g]corannulene and Dibenzo[a,g]cyclopenta[kl]corannulene von Weitz, Amir, Shabtai, Elad, Rabinovitz, Mordecai, Bratcher, Matthew S., McComas, Casey C., Best, Michael D., Scott, Lawrence T.

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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines von Mahaney, Paige E., Vu, An T., McComas, Casey C., Zhang, Puwen, Nogle, Lisa M., Watts, William L., Sarkahian, Ani, Leventhal, Liza, Sullivan, Nicole R., Uveges, Albert J., Trybulski, Eugene J.

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Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: A new class of selective norepinephrine reuptake inhibitors von McComas, Casey C., Vu, An T., Mahaney, Paige E., Cohn, Stephen T., Fensome, Andrew, Marella, Michael A., Nogle, Lisa, Trybulski, Eugene J., Ye, Fei, Zhang, Puwen, Alfinito, Peter, Bray, Jenifer, Johnston, Grace, Koury, Elizabeth, Deecher, Darlene C.

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Application of chiral lithium amide bases to the thia-Sommelet dearomatization reaction von McComas, Casey C., Van Vranken, David L.

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Large-Scale Synthesis of a Selective Inhibitor of the Norepinephrine Transporter: Mechanistic Aspects of Conversion of Indolinone Diol to Indolinone Aminoalcohol and Process Implic... von Alimardanov, Asaf, Gontcharov, Alexander, Nikitenko, Antonia, Chan, Anita W, Ding, Zhixian, Ghosh, Mousumi, Levent, Mahmut, Raveendranath, Panolil, Ren, Jianxin, Zhou, Maotang, Mahaney, Paige E, McComas, Casey C, Ashcroft, Joseph, Potoski, John R

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