Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA von Zheng, Hongchao, Botos, Istvan, Clausse, Victor, Nikolayevskiy, Herman, Rastede, Elizabeth E, Fouz, Munira F, Mazur, Sharlyn J, Appella, Daniel H

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Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma von Veschi, Veronica, Liu, Zhihui, Voss, Ty C., Ozbun, Laurent, Gryder, Berkley, Yan, Chunhua, Hu, Ying, Ma, Anqi, Jin, Jian, Mazur, Sharlyn J., Lam, Norris, Souza, Barbara K., Giannini, Giuseppe, Hager, Gordon L., Arrowsmith, Cheryl H., Khan, Javed, Appella, Ettore, Thiele, Carol J.

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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression von Lin, Tongxiang, Chao, Connie, Saito, Shin'ichi, Mazur, Sharlyn J., Murphy, Maureen E., Appella, Ettore, Xu, Yang

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Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses von Uyanik, Burhan, Goloudina, Anastasia R., Akbarali, Aamir, Grigorash, Bogdan B., Petukhov, Alexey V., Singhal, Sunil, Eruslanov, Evgeniy, Chaloyard, Jeanne, Lagorgette, Lisa, Hadi, Tarik, Baidyuk, Ekaterina V., Sakai, Hiroyasu, Tessarollo, Lino, Ryffel, Bernhard, Mazur, Sharlyn J., Lirussi, Frederic, Garrido, Carmen, Appella, Ettore, Demidov, Oleg N.

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A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity von Debnath, Subrata, Kosek, Dalibor, Tagad, Harichandra D., Durell, Stewart R., Appella, Daniel H., Acevedo, Roderico, Grishaev, Alexander, Dyda, Fred, Appella, Ettore, Mazur, Sharlyn J.

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Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation von Feng, Hanqiao, Jenkins, Lisa M. Miller, Durell, Stewart R., Hayashi, Ryo, Mazur, Sharlyn J., Cherry, Scott, Tropea, Joseph E., Miller, Maria, Wlodawer, Alexander, Appella, Ettore, Bai, Yawen

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Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile von Brown, Kate, Jenkins, Lisa M Miller, Crooks, Daniel R, Surman, Deborah R, Mazur, Sharlyn J, Xu, Yuan, Arimilli, Bhargav S, Yang, Ye, Lane, Andrew N, Fan, Teresa W-M, Schrump, David S, Linehan, W Marston, Ripley, R Taylor, Appella, Ettore

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Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents von Goloudina, Anastasia R, Tanoue, Kan, Hammann, Arlette, Fourmaux, Eric, Le Guezennec, Xavier, Bulavin, Dmitry V, Mazur, Sharlyn J, Appella, Ettore, Garrido, Carmen, Demidov, Oleg N

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Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain von Tagad, Harichandra D., Debnath, Subrata, Clausse, Victor, Saha, Mrinmoy, Mazur, Sharlyn J., Appella, Ettore, Appella, Daniel H.

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Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio von Goloudina, Anastasia R., Mazur, Sharlyn J., Appella, Ettore, Garrido, Carmen, Demidov, Oleg N.

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An Acetyl-Methyl Switch Drives a Conformational Change in p53 von Tong, Qiong, Mazur, Sharlyn J., Rincon-Arano, Hector, Rothbart, Scott B., Kuznetsov, Dmitry M., Cui, Gaofeng, Liu, Wallace H., Gete, Yantenew, Klein, Brianna J., Jenkins, Lisa, Mer, Georges, Kutateladze, Andrei G., Strahl, Brian D., Groudine, Mark, Appella, Ettore, Kutateladze, Tatiana G.

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UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells von Oh, Kyu-Seon, Bustin, Michael, Mazur, Sharlyn J., Appella, Ettore, Kraemer, Kenneth H.

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Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage von Chao, Connie, Wu, Zhiqun, Mazur, Sharlyn J., Borges, Helena, Rossi, Matteo, Lin, Tongxiang, Wang, Jean Y. J., Anderson, Carl W., Appella, Ettore, Xu, Yang

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Two Distinct Motifs within the p53 Transactivation Domain Bind to the Taz2 Domain of p300 and Are Differentially Affected by Phosphorylation von Jenkins, Lisa M. Miller, Yamaguchi, Hiroshi, Hayashi, Ryo, Cherry, Scott, Tropea, Joseph E, Miller, Maria, Wlodawer, Alexander, Appella, Ettore, Mazur, Sharlyn J

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p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes von Mondal, Abdul M, Horikawa, Izumi, Pine, Sharon R, Fujita, Kaori, Morgan, Katherine M, Vera, Elsa, Mazur, Sharlyn J, Appella, Ettore, Vojtesek, Borivoj, Blasco, Maria A, Lane, David P, Harris, Curtis C

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Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain von Kumar, Jay Prakash, Kosek, Dalibor, Durell, Stewart R., Miller Jenkins, Lisa M., Debnath, Subrata, Coussens, Nathan P., Hall, Matthew D., Appella, Daniel H., Dyda, Fred, Mazur, Sharlyn J., Appella, Ettore

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Regulation of the Wip1 phosphatase and its effects on the stress response von Lowe, Julie, Cha, Hyukjin, Lee, Mi-Ok, Mazur, Sharlyn J, Appella, Ettore, Fornace, Jr, Albert J

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The Area Between Exchange Curves as a Measure of Conformational Differences in Hydrogen-Deuterium Exchange Mass Spectrometry Studies von Mazur, Sharlyn J., Weber, Daniel P.

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p53 N-terminal phosphorylation: a defining layer of complex regulation von MILLER JENKINS, Lisa M, DURELL, Stewart R, MAZUR, Sharlyn J, APPELLA, Ettore

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Variation of Tetrahydrofurans in Thyclotides Enhances Oligonucleotide Binding and Cellular Uptake of Peptide Nucleic Acids von Zheng, Hongchao, Clausse, Victor, Amarasekara, Harsha, Mazur, Sharlyn J., Botos, Istvan, Appella, Daniel H.

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