Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias von Fowler-Shorten, Dominic J, Maynard, Rebecca S, Hampton, Katherine, Altera, Annalisa, Markham, Matthew, Ehikioya, Martha, Wojtowicz, Edyta E, Bowles, Kristian M, Rushworth, Stuart A, Hellmich, Charlotte

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Using Iterative Experimentation to Accelerate Program Improvement: A Case Example von Maynard, Rebecca A., Baelen, Rebecca N., Fein, David, Souvanna, Phomdaen

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Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche von Maynard, Rebecca S., Hellmich, Charlotte, Bowles, Kristian M., Rushworth, Stuart A.

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Improving the Usefulness and Use of Meta-Analysis to Inform Policy and Practice von Maynard, Rebecca

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P1341: LC3-ASSOCIATED PHAGOCYTOSIS IS IMPAIRED IN BONE MARROW MACROPHAGES DURING AGEING LEADING TO DEFECTIVE PHAGOCYTOSIS AND ACCUMULATION OF APOPTOTIC DEBRIS WITHIN THE BONE MARRO... von Hampton, Katherine, Hellmich, Charlotte, Maynard, Rebecca, Jibril, Aisha, Moore, Jamie, Bowles, Kristian, Rushworth, Stuart

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P469: ACUTE MYELOID LEUKEMIA DRIVES BCL‐2 UPREGULATION IN NON MALIGNANT HSPCS WHICH IS TARGETED BY VENETOCLAX AND CAUSES CYTOPENIA von Fowler‐Shorten, Dominic, Maynard, Rebecca, Hampton, Katherine, Ehikioya, Martha, De Silva, Ravindu, Bowles, Kristian, Rushworth, Stuart, Hellmich, Charlotte

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P856: MULTIPLE MYELOMA DERIVED IL‐6 REDUCES FATTY ACID METABOLISM IN THE LIVER BY DOWNREGULATING CD36 AND CPT1A IN HEPATOCYTES von Egheose Ehikioya, Martha, Maynard, Rebecca, Hampton, Katherine, Hellmich, Charlotte, De Silva, Ravindu, Fowler‐Shorten, Dominic, Bowles, Kristian, Rushworth, Stuart

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Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages von Wojtowicz, Edyta E., Hampton, Katherine, Moreno-Gonzalez, Mar, Utting, Charlotte L., Lan, Yuxuan, Ruiz, Paula, Beasy, Gemma, Bone, Caitlin, Hellmich, Charlotte, Maynard, Rebecca, Acton, Luke, Markham, Matthew, Troeberg, Linda, Telatin, Andrea, Kingsley, Robert A., Macaulay, Iain C., Rushworth, Stuart A., Beraza, Naiara

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Procalcitonin-Guided Antibiotic Discontinuation: An Antimicrobial Stewardship Initiative to Assist Providers von Vaillant, James J, Mersfelder, Tracey L, Maynard, Rebecca S, Kavanaugh, Kevin

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Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia von Maynard, Rebecca S, Hellmich, Charlotte, Hampton, Katherine, Jibril, Aisha, Bowles, Kristian M, Rushworth, Stuart A

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Sphingomyelinase Regulates the Release of Protumoral Mitochondria Containing-Vesicles from AML Cells von Markham, Matthew, Riley, David, Maynard, Rebecca S, Hampton, Katherine, De Silva, Ravindu, Hellmich, Charlotte, Bowles, Kristian, Rushworth, Stuart

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IL-6 Mediates a Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support HSC Expansion during Infection von Hampton, Katherine, Mistry, Jayna, Maynard, Rebecca S, Fowler-Shorten, Dominic, Hellmich, Charlotte, Beraza, Naiara, Bowles, Kristian, Rushworth, Stuart

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Editors' Introduction: Randomized Controlled Trials Meet the Real World: The Nature and Consequences of Null Findings von Herrington, Carolyn D., Maynard, Rebecca

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Presidential address: Evidence-based decision making: What will it take for the decision makers to care? von Maynard, Rebecca A.

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AML Inhibits Lipid Uptake By the Liver through an HGF/c-MET Dependent Mechanism Which Results in an Increased Supply of Free Fatty Acid to the Tumor von Maynard, Rebecca S, Hellmich, Charlotte, Hampton, Katherine, Fowler-Shorten, Dominic, Markham, Matthew, Altera, Annalisa, Flint, Thomas, De Silva, Ravindu, Beraza, Naiara, Bowles, Kristian, Rushworth, Stuart

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Multiple Myeloma Induced IL-6 Reprograms Lipid Metabolism through a CD36 Dependent Mechanism von Ehikioya, Martha, Altera, Annalisa, Hampton, Katherine, Maynard, Rebecca S, Fowler-Shorten, Dominic, Hellmich, Charlotte, Bowles, Kristian, Markham, Matthew, De Silva, Ravindu, Rushworth, Stuart

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Fighting for Reliable Evidence, by Judith Gueron and Howard Rolston, New York, NY: Russell Sage Foundation, 2013, 596 pp., $49.45, paperback: Book Reviews von Maynard, Rebecca A.

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Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals von Hellmich, Charlotte, Wojtowicz, Edyta, Maynard, Rebecca S, Hampton, Katherine, Mistry, Jayna J, Moore, Jamie A, Jibril, Aisha, Utting, Charlotte L, Macauley, Iain, Bowles, Kristian M, Rushworth, Stuart A

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Release of miR-29 Target Laminin C2 Improves Skin Repair von Robinson, Connor J, Thiagarajan, Lalitha, Maynard, Rebecca, Aruketty, Maneesha, Herrera, Jeremy, Dingle, Lewis, Reid, Adam, Wong, Jason, Cao, Heng, Dooley, James, Liston, Adrian, Müllhaupt, Daniela, Hiebert, Paul, Hiebert, Hayley, Kurinna, Svitlana

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STRENGTHENING THE REGRESSION DISCONTINUITY DESIGN USING ADDITIONAL DESIGN ELEMENTS: A WITHIN-STUDY COMPARISON von Wing, Coady, Cook, Thomas D.

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