Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation von Gilbert, Luke A., Horlbeck, Max A., Adamson, Britt, Villalta, Jacqueline E., Chen, Yuwen, Whitehead, Evan H., Guimaraes, Carla, Panning, Barbara, Ploegh, Hidde L., Bassik, Michael C., Qi, Lei S., Kampmann, Martin, Weissman, Jonathan S.

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A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility von Bassik, Michael C., Kampmann, Martin, Lebbink, Robert Jan, Wang, Shuyi, Hein, Marco Y., Poser, Ina, Weibezahn, Jimena, Horlbeck, Max A., Chen, Siyuan, Mann, Matthias, Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.

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Exploring genetic interaction manifolds constructed from rich single-cell phenotypes von Norman, Thomas M, Horlbeck, Max A, Replogle, Joseph M, Ge, Alex Y, Xu, Albert, Jost, Marco, Gilbert, Luke A, Weissman, Jonathan S

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A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response von Adamson, Britt, Norman, Thomas M., Jost, Marco, Cho, Min Y., Nuñez, James K., Chen, Yuwen, Villalta, Jacqueline E., Gilbert, Luke A., Horlbeck, Max A., Hein, Marco Y., Pak, Ryan A., Gray, Andrew N., Gross, Carol A., Dixit, Atray, Parnas, Oren, Regev, Aviv, Weissman, Jonathan S.

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Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation von Horlbeck, Max A, Gilbert, Luke A, Villalta, Jacqueline E, Adamson, Britt, Pak, Ryan A, Chen, Yuwen, Fields, Alexander P, Park, Chong Yon, Corn, Jacob E, Kampmann, Martin, Weissman, Jonathan S

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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element von Cho, Seung Woo, Xu, Jin, Sun, Ruping, Mumbach, Maxwell R., Carter, Ava C., Chen, Y. Grace, Yost, Kathryn E., Kim, Jeewon, He, Jing, Nevins, Stephanie A., Chin, Suet-Feung, Caldas, Carlos, Liu, S. John, Horlbeck, Max A., Lim, Daniel A., Weissman, Jonathan S., Curtis, Christina, Chang, Howard Y.

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CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells von Liu, S. John, Horlbeck, Max A., Cho, Seung Woo, Birk, Harjus S., Malatesta, Martina, He, Daniel, Attenello, Frank J., Villalta, Jacqueline E., Cho, Min Y., Chen, Yuwen, Mandegar, Mohammad A., Olvera, Michael P., Gilbert, Luke A., Conklin, Bruce R., Chang, Howard Y., Weissman, Jonathan S., Lim, Daniel A.

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Mapping the Genetic Landscape of Human Cells von Horlbeck, Max A., Xu, Albert, Wang, Min, Bennett, Neal K., Park, Chong Y., Bogdanoff, Derek, Adamson, Britt, Chow, Eric D., Kampmann, Martin, Peterson, Tim R., Nakamura, Ken, Fischbach, Michael A., Weissman, Jonathan S., Gilbert, Luke A.

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Single-cell analysis of long non-coding RNAs in the developing human neocortex von Liu, Siyuan John, Nowakowski, Tomasz J, Pollen, Alex A, Lui, Jan H, Horlbeck, Max A, Attenello, Frank J, He, Daniel, Weissman, Jonathan S, Kriegstein, Arnold R, Diaz, Aaron A, Lim, Daniel A

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Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs von Jost, Marco, Santos, Daniel A., Saunders, Reuben A., Horlbeck, Max A., Hawkins, John S., Scaria, Sonia M., Norman, Thomas M., Hussmann, Jeffrey A., Liem, Christina R., Gross, Carol A., Weissman, Jonathan S.

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Nucleosomes impede Cas9 access to DNA in vivo and in vitro von Horlbeck, Max A, Witkowsky, Lea B, Guglielmi, Benjamin, Replogle, Joseph M, Gilbert, Luke A, Villalta, Jacqueline E, Torigoe, Sharon E, Tjian, Robert, Weissman, Jonathan S

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CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs von Mandegar, Mohammad A., Huebsch, Nathaniel, Frolov, Ekaterina B., Shin, Edward, Truong, Annie, Olvera, Michael P., Chan, Amanda H., Miyaoka, Yuichiro, Holmes, Kristin, Spencer, C. Ian, Judge, Luke M., Gordon, David E., Eskildsen, Tilde V., Villalta, Jacqueline E., Horlbeck, Max A., Gilbert, Luke A., Krogan, Nevan J., Sheikh, Søren P., Weissman, Jonathan S., Qi, Lei S., So, Po-Lin, Conklin, Bruce R.

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CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma von Liu, S John, Malatesta, Martina, Lien, Brian V, Saha, Parna, Thombare, Shivani S, Hong, Sung Jun, Pedraza, Leslie, Koontz, Mark, Seo, Kyounghee, Horlbeck, Max A, He, Daniel, Birk, Harjus S, Jain, Miten, Olsen, Hugh E, Akeson, Mark, Weissman, Jonathan S, Monje, Michelle, Gupta, Nalin, Raleigh, David R, Ullian, Erik M, Lim, Daniel A

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Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification von Deans, Richard M, Morgens, David W, Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A, Kampmann, Martin, Gilbert, Luke A, Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S, Carette, Jan E, Khosla, Chaitan, Bassik, Michael C

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Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation von Braun, Christian J., Bruno, Peter M., Horlbeck, Max A., Gilbert, Luke A., Weissman, Jonathan S., Hemann, Michael T.

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Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes von Horlbeck, Max A., Liu, S. John, Chang, Howard Y., Lim, Daniel A., Weissman, Jonathan S.

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Cellular response to small molecules that selectively stall protein synthesis by the ribosome von Liaud, Nadège, Horlbeck, Max A, Gilbert, Luke A, Gjoni, Ketrin, Weissman, Jonathan S, Cate, Jamie H D

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A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure von Mendelsohn, Bryce A, Bennett, Neal K, Darch, Maxwell A, Yu, Katharine, Nguyen, Mai K, Pucciarelli, Daniela, Nelson, Maxine, Horlbeck, Max A, Gilbert, Luke A, Hyun, William, Kampmann, Martin, Nakamura, Jean L, Nakamura, Ken

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Next-generation libraries for robust RNA interference-based genome-wide screens von Kampmann, Martin, Max A. Horlbeck, Yuwen Chen, Jordan C. Tsai, Michael C. Bassik, Luke A. Gilbert, Jacqueline E. Villalta, S. Chul Kwon, Hyeshik Chang, V. Narry Kim, Jonathan S. Weissman

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ER Cargo Properties Specify a Requirement for COPII Coat Rigidity Mediated by Sec13p von Čopič, Alenka, Latham, Catherine F., Horlbeck, Max A., D'Arcangelo, Jennifer G., Miller, Elizabeth A.

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