Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease von Caruso, Antonello, Vollmer, Jannik, Machacek, Matthias, Kortvely, Elod

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Coordination of Rho GTPase activities during cell protrusion von Welch, Christopher, Elliott, Hunter, Johnson, Gary L, Nalbant, Perihan, Hodgson, Louis, Pertz, Olivier, Danuser, Gaudenz, Abell, Amy, Hahn, Klaus M, Machacek, Matthias

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NfL concentration in CSF is a quantitative marker of the rate of neurodegeneration in aging and Huntington's disease: a semi-mechanistic model-based analysis von Machacek, Matthias, Garcia-Montoya, Elena, McColgan, Peter, Sanwald-Ducray, Patricia, Mazer, Norman Alan

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Cofilin Activity Downstream of Pak1 Regulates Cell Protrusion Efficiency by Organizing Lamellipodium and Lamella Actin Networks von Delorme, Violaine, Machacek, Matthias, DerMardirossian, Céline, Anderson, Karen L., Wittmann, Torsten, Hanein, Dorit, Waterman-Storer, Clare, Danuser, Gaudenz, Bokoch, Gary M.

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Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4 von Griffiths, Katherine, Binder, Uli, McDowell, William, Tommasi, Rita, Frigerio, Mark, Darby, William G, Hosking, Chris G, Renaud, Lionel, Machacek, Matthias, Lloyd, Peter, Skerra, Arne, Foley, Michael

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Quantitative imaging of epithelial cell scattering identifies specific inhibitors of cell motility and cell-cell dissociation von Loerke, Dinah, le Duc, Quint, Blonk, Iris, Kerstens, Andre, Spanjaard, Emma, Machacek, Matthias, Danuser, Gaudenz, de Rooij, Johan

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Protrusion and actin assembly are coupled to the organization of lamellar contractile structures von Lim, James I., Sabouri-Ghomi, Mohsen, Machacek, Matthias, Waterman, Clare M., Danuser, Gaudenz

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Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab: First-in-Human Healthy Volunteer Trial von Voors-Pette, Christine, Lebozec, Kristell, Dogterom, Peter, Jullien, Laurie, Billiald, Philippe, Ferlan, Pauline, Renaud, Lionel, Favre-Bulle, Olivier, Avenard, Gilles, Machacek, Matthias, Plétan, Yannick, Jandrot-Perrus, Martine

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Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model von Bernhard, Fabian, Odedra, Rajesh, Sordello, Sylvie, Cardin, Rossella, Franzoni, Samantha, Charrier, Cédric, Belley, Adam, Warn, Peter, Machacek, Matthias, Knechtle, Philipp

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2529. Population pharmacokinetic models for cefepime and enmetazobactam derived from pooled Phase 1 to Phase 3 clinical studies von Vollmer, Jannik, Belley, Adam, Velicitat, Patrick, Machacek, Matthias

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Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation von Renaud, Lionel, Lebozec, Kristell, Voors‐Pette, Christine, Dogterom, Peter, Billiald, Philippe, Jandrot Perrus, Martine, Pletan, Yannick, Machacek, Matthias

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Prediction of Cardiac ATTR Depletion by NI006 (ALXN2220) Using Mechanistic PK/PD Modeling von Michalon, Aubin, Renaud, Lionel, Machacek, Matthias, Cortijo, Cédric, Udata, Chandrasekhar, Mercuri, Michele F., Buller, Fabian, Hock, Christoph, Nitsch, Roger M., Kahr, Peter C., Grimm, Jan

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Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease von Antonello Caruso, Jannik Vollmer, Matthias Machacek, Elod Kortvely, James R. Faeder

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Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers von Bolognani, Federico, Kruithof, Annelieke C., Schulthess, Pascal, Machacek, Matthias, de Kam, Marieke L., Bergmann, Kirsten R., van Gent, Max, Moerland, Matthijs, Crenn, Pascal, Greig, Gérard, Gal, Pim

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Re‐estimation of drug‐specific amyloid removal parameters and the rate constant for pathogenic tau turnover brings the Q‐ATN model into better alignment with recent phase 3 data fr... von Mazer, Norman A, Lott, Dominik, Grimm, Hans Peter, Machacek, Matthias, Boess, Frank, Gieschke, Ronald, Klein, Gregory, Baudler, Monika, Doody, Rachelle S.

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Abstract CT206: A phase I open-label, dose escalation and expansion trial to investigate the safety, pharmacokinetics and pharmacodynamics of CB307, a trispecific Humabody T-cell e... von Hashimoto, Kenji, Pierce, Andrew J., Chau, Albert, Bartlett, Phillip, Lloyd, Peter, Maginn, Mark, Machacek, Matthias, Vollmer, Jannik, Rajbally, Sultanah, Tilson, Julia, Bland-Ward, Phil

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Su559 POPULATION MODEL CONFIRMS PREDICTABLE PHARMACOKINETIC (PK) AND PHARMACODYNAMIC (PD) PROFILE FOR APRAGLUTIDE - DATA FROM TWO RANDOMIZED PHASE 1 STUDIES von Bolognani, Federico, Machacek, Matthias, Kruithof, Annelieke, de Kam, Marieke L., Bergmann, Kirsten, van Gent, Max, Moerland, Matthijs, Crenn, Pascal, Meyer, Christian, Greig, Gerard, Gal, Pim, Schulthess, Pascal

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Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours von Melero, Ignacio, de Miguel Luken, Maria, de Velasco, Guillermo, Garralda, Elena, Martín-Liberal, Juan, Joerger, Markus, Alonso, Guzman, Goebeler, Maria-Elisabeth, Schuler, Martin, König, David, Dummer, Reinhard, Reig, Maria, Rodriguez Ruiz, Maria-Esperanza, Calvo, Emiliano, Esteban-Villarrubia, Jorge, Oberoi, Arjun, Sabat, Paula, Soto-Castillo, Juan José, Koster, Kira-Lee, Saavedra, Omar, Sayehli, Cyrus, Gromke, Tanja, Läubli, Heinz, Ramelyte, Egle, Fortuny, Marta, Landa-Magdalena, Ana, Moreno, Irene, Torres-Jiménez, Javier, Hernando-Calvo, Alberto, Hess, Dagmar, Racca, Fabricio, Richly, Heike, Schmitt, Andreas M, Eggenschwiler, Corinne, Sanduzzi-Zamparelli, Marco, Vilalta-Lacarra, Anna, Trojan, Jörg, Koch, Christine, Galle, Peter R, Foerster, Friedrich, Trajanoski, Zlatko, Hackl, Hubert, Gogolla, Falk, Koll, Florestan J, Wild, Peter, Chun, Felix Kyoung Hwan, Reis, Henning, Lloyd, Peter, Machacek, Matthias, Gajewski, Thomas F, Fridman, Wolf H, Eggermont, Alexander M M, Bargou, Ralf, Schöniger, Sandra, Rüschoff, Josef, Tereshchenko, Anastasiia, Zink, Carina, da Silva, Antonio, Lichtenegger, Felix S, Akdemir, Julia, Rüdiger, Manfred, L'Huillier, Phil, Dutta, Aradhana, Haake, Markus, Auckenthaler, Alexandra, Gjorgjioska, Ana, Rössler, Bernhard, Hermann, Frank, Liebig, Mara, Reichhardt, Daniela, Schuberth-Wagner, Christine, Wischhusen, Jörg, Fettes, Petra, Auer, Marlene, Klar, Kathrin, Leo, Eugen

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Intrathecal administration of Anti-Nogo-A antibody in macaque monkeys: Pharmacokinetics, tissue penetration and target interaction von Kunz, Pascal B., Maurer, Michael A., Vollmer, Jannik, Machacek, Matthias, Weinmann, Oliver, Klisic, Jelena, Schwab, Martin E.

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Population pharmacokinetics of PQR309, a dual PI3K/mTOR inhibitor in adult patients with advanced solid tumors von Machacek, Matthias, Renaud, Lionel, Dimitrijevic, Sasa, Schmitz, Debora, Ivanova, Elena, Jorga, Karin

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