Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines von Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.

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Impact of mRNA chemistry and manufacturing process on innate immune activation von Nelson, Jennifer, Sorensen, Elizabeth W., Mintri, Shrutika, Rabideau, Amy E., Zheng, Wei, Besin, Gilles, Khatwani, Nikhil, Su, Stephen, Miracco, Edward J., Issa, William J., Hoge, Stephen, Stanton, Matthew G., Joyal, John L.

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5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates von Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant

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Current Status of Messenger RNA Delivery Systems von Stanton, Matthew G.

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Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing von Chang, Wonsuk, Pei, Yi, Guidry, Erin N., Zewge, Daniel, Parish, Craig A., Sherer, Edward C., DiMuzio, Jillian, Zhang, Hangchun, South, Victoria J., Strapps, Walter R., Sepp-Lorenzino, Laura, Colletti, Steven L., Stanton, Matthew G.

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Asymmetric Total Synthesis of (−)-Laulimalide:  Exploiting the Asymmetric Glycolate Alkylation Reaction von Crimmins, Michael T, Stanton, Matthew G, Allwein, Shawn P

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Medicinal Chemistry of siRNA Delivery von Stanton, Matthew G, Colletti, Steven L

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A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates von Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Ketova, Tatiana, Senn, Joseph J., Lynn, Andy, Bulychev, Alex, McFadyen, Iain, Chan, Joyce, Almarsson, Örn, Stanton, Matthew G., Benenato, Kerry E.

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Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry von Lee, Anita Y. H, Paweletz, Cloud P, Pollock, Roy M, Settlage, Robert E, Cruz, Jonathan C, Secrist, J. Paul, Miller, Thomas A, Stanton, Matthew G, Kral, Astrid M, Ozerova, Nicole D. S, Meng, Fanyu, Yates, Nathan A, Richon, Victoria, Hendrickson, Ronald C

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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors von Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) von Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman prim... von Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J

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Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties von Sloman, David L., Noucti, Njamkou, Altman, Michael D., Chen, Dapeng, Mislak, Andrea C., Szewczak, Alexander, Hayashi, Mansuo, Warren, Lee, Dellovade, Tammy, Wu, Zhenhua, Marcus, Jacob, Walker, Deborah, Su, Hua-Poo, Edavettal, Suzanne C., Munshi, Sanjeev, Hutton, Michael, Nuthall, Hugh, Stanton, Matthew G.

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A Mild Protocol for the Conversion of Simple Esters to tert-Butyl Esters von Stanton, Matthew G, Gagné, Michel R

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The Remarkable Catalytic Activity of Alkali-Metal Alkoxide Clusters in the Ester Interchange Reaction von Stanton, Matthew G, Gagné, Michel R

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Inside Cover: 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016) von Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant

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“New” Catalysts for the Ester-Interchange Reaction:  The Role of Alkali-Metal Alkoxide Clusters in Achieving Unprecedented Reaction Rates von Stanton, Matthew G, Allen, Cara B, Kissling, Rebecca M, Lincoln, Alice L, Gagné, Michel R

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Fluorinated piperidine acetic acids as γ-secretase modulators von Stanton, Matthew G., Hubbs, Jed, Sloman, David, Hamblett, Christopher, Andrade, Paula, Angagaw, Minilik, Bi, Grace, Black, Regina M., Crispino, Jamie, Cruz, Jonathan C., Fan, Eric, Farris, Georgia, Hughes, Bethany L., Kenific, Candia M., Middleton, Richard E., Nikov, George, Sajonz, Peter, Shah, Sanjiv, Shomer, Nirah, Szewczak, Alexander A., Tanga, Flobert, Tudge, Matthew T., Shearman, Mark, Munoz, Benito

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Discovery of Isonicotinamide Derived β-Secretase Inhibitors:  In Vivo Reduction of β-Amyloid von Stanton, Matthew G, Stauffer, Shaun R, Gregro, Alison R, Steinbeiser, Melissa, Nantermet, Philippe, Sankaranarayanan, Sethu, Price, Eric A, Wu, Guoxin, Crouthamel, Ming-Chih, Ellis, Joan, Lai, Ming-Tain, Espeseth, Amy S, Shi, Xiao-Ping, Jin, Lixia, Colussi, Dennis, Pietrak, Beth, Huang, Qian, Xu, Min, Simon, Adam J, Graham, Samuel L, Vacca, Joseph P, Selnick, Harold

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor von Methot, Joey L, Hoffman, Dawn Mampreian, Witter, David J, Stanton, Matthew G, Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M, Ozerova, Nicole, Fleming, Judith C, Wang, Hongmei, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany, Cruz, Jonathan C, Haines, Brian B, Chenard, Melissa, Kenific, Candia M, Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A

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