Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms von Mealka, Matthew, Sierra, Nicole A., Avellaneda Matteo, Diego, Albekioni, Elene, Khoury, Rachel, Mai, Timothy, Conley, Brittany M., Coleman, Nalani J., Sabo, Kaitlyn A., Komives, Elizabeth A., Bobkov, Andrey A., Cooksy, Andrew L., Silletti, Steve, Schiffer, Jamie M., Huxford, Tom, Sohl, Christal D.

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Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen–Deuterium Exchange Mass Spectrometry von Sabo, Kaitlyn A., Albekioni, Elene, Caliger, Danielle, Coleman, Nalani J., Thornberg, Ella, Avellaneda Matteo, Diego, Komives, Elizabeth A., Silletti, Steve, Sohl, Christal D.

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Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency von Avellaneda Matteo, Diego, Grunseth, Adam J., Gonzalez, Eric R., Anselmo, Stacy L., Kennedy, Madison A., Moman, Precious, Scott, David A., Hoang, An, Sohl, Christal D.

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Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants von Avellaneda Matteo, Diego, Wells, Grace A, Luna, Lucas A, Grunseth, Adam J, Zagnitko, Olga, Scott, David A, Hoang, An, Luthra, Amit, Swairjo, Manal A, Schiffer, Jamie M, Sohl, Christal D

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Understanding the Structure‐Function Relationship of IDH1 R132 mutants and the Effect of Allosteric Inhibitors von Matteo, Diego Avellaneda, Wells, Grace, Grunseth, Adam, Schiffer, Jamie, Sohl, Christal

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Molecular Mechanisms of Isocitrate Dehydrogenase 1 Mutants in Driving the Oncogenic Neomorphic Reaction von Quichocho, Giovanni Garrido, Xu, Ruth, Luna, Lucas, Matteo, Diego Avellaneda, Scott, Michelle, Fonbon, Jeon Erik, Sohl, Christal D.

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The effect of acetylation on isocitrate dehydrogenase 1 regulation von Strom, Alexandra, Widjaja, Vinnie, Weeks, Joi, Alexander, Sati, Pucher, Dahra, Nguyen, Tin Duc, Luna, Lucas, Matteo, Diego Avellaneda, Hoang, An, Sohl, Christal D.

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The Catalytic Features of IDH1 Mutations Can Drive Neomorphic Activity, Phenotype Severity, and Inhibitor Binding von Sohl, Christal D., Matteo, Diego Avellaneda, Wells, Grace, Luna, Lucas, Upadhye, Viraj, Quichocho, Giovanni, Chambers, Jennifer M., Miller, Wade, Scott, David, Schiffer, Jamie M.

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Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity von Chambers, Jennifer M, Miller, Wade, Quichocho, Giovanni, Upadhye, Viraj, Matteo, Diego Avellaneda, Bobkov, Andrey A, Sohl, Christal D, Schiffer, Jamie M

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Enzymes Running in Reverse: Catalytic Studies on Isocitrate Dehydrogenase Mutations Implicated in Cancer von Sohl, Christal, Matteo, Diego Avellaneda, Grunseth, Adam, Anselmo, Stacy, Gonzalez, Eric, Kennedy, Madison

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