Perturbation-response genes reveal signaling footprints in cancer gene expression von Schubert, Michael, Klinger, Bertram, Klünemann, Martina, Sieber, Anja, Uhlitz, Florian, Sauer, Sascha, Garnett, Mathew J., Blüthgen, Nils, Saez-Rodriguez, Julio

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Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens von Behan, Fiona M., Iorio, Francesco, Picco, Gabriele, Gonçalves, Emanuel, Beaver, Charlotte M., Migliardi, Giorgia, Santos, Rita, Rao, Yanhua, Sassi, Francesco, Pinnelli, Marika, Ansari, Rizwan, Harper, Sarah, Jackson, David Adam, McRae, Rebecca, Pooley, Rachel, Wilkinson, Piers, van der Meer, Dieudonne, Dow, David, Buser-Doepner, Carolyn, Bertotti, Andrea, Trusolino, Livio, Stronach, Euan A., Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J.

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Effective drug combinations in breast, colon and pancreatic cancer cells von Jaaks, Patricia, Coker, Elizabeth A., Vis, Daniel J., Edwards, Olivia, Carpenter, Emma F., Leto, Simonetta M., Dwane, Lisa, Sassi, Francesco, Lightfoot, Howard, Barthorpe, Syd, van der Meer, Dieudonne, Yang, Wanjuan, Beck, Alexandra, Mironenko, Tatiana, Hall, Caitlin, Hall, James, Mali, Iman, Richardson, Laura, Tolley, Charlotte, Morris, James, Thomas, Frances, Lleshi, Ermira, Aben, Nanne, Benes, Cyril H., Bertotti, Andrea, Trusolino, Livio, Wessels, Lodewyk, Garnett, Mathew J.

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A Landscape of Pharmacogenomic Interactions in Cancer von Iorio, Francesco, Knijnenburg, Theo A., Vis, Daniel J., Bignell, Graham R., Menden, Michael P., Schubert, Michael, Aben, Nanne, Gonçalves, Emanuel, Barthorpe, Syd, Lightfoot, Howard, Cokelaer, Thomas, Greninger, Patricia, van Dyk, Ewald, Chang, Han, de Silva, Heshani, Heyn, Holger, Deng, Xianming, Egan, Regina K., Liu, Qingsong, Mironenko, Tatiana, Mitropoulos, Xeni, Richardson, Laura, Wang, Jinhua, Zhang, Tinghu, Moran, Sebastian, Sayols, Sergi, Soleimani, Maryam, Tamborero, David, Lopez-Bigas, Nuria, Ross-Macdonald, Petra, Esteller, Manel, Gray, Nathanael S., Haber, Daniel A., Stratton, Michael R., Benes, Cyril H., Wessels, Lodewyk F.A., Saez-Rodriguez, Julio, McDermott, Ultan, Garnett, Mathew J.

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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening von Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique MA, Francies, Hayley E, Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert, Sidorova, Olga, Gaspersz, Marcia P, Georgakopoulos, Nikitas, Koo, Bon-Kyoung, Dietmann, Sabine, Davies, Susan E, Praseedom, Raaj K, Lieshout, Ruby, IJzermans, Jan N M, Wigmore, Stephen J, Saeb-Parsy, Kourosh, Garnett, Mathew J, van der Laan, Luc JW, Huch, Meritxell

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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening von Driehuis, Else, van Hoeck, Arne, Moore, Kat, Kolders, Sigrid, Francies, Hayley E., Gulersonmez, M. Can, Stigter, Edwin C. A., Burgering, Boudewijn, Geurts, Veerle, Gracanin, Ana, Bounova, Gergana, Morsink, Folkert H., Vries, Robert, Boj, Sylvia, van Es, Johan, Offerhaus, G. Johan A., Kranenburg, Onno, Garnett, Mathew J., Wessels, Lodewyk, Cuppen, Edwin, Brosens, Lodewijk A. A., Clevers, Hans

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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients von van de Wetering, Marc, Francies, Hayley E., Francis, Joshua M., Bounova, Gergana, Iorio, Francesco, Pronk, Apollo, van Houdt, Winan, van Gorp, Joost, Taylor-Weiner, Amaro, Kester, Lennart, McLaren-Douglas, Anne, Blokker, Joyce, Jaksani, Sridevi, Bartfeld, Sina, Volckman, Richard, van Sluis, Peter, Li, Vivian S.W., Seepo, Sara, Sekhar Pedamallu, Chandra, Cibulskis, Kristian, Carter, Scott L., McKenna, Aaron, Lawrence, Michael S., Lichtenstein, Lee, Stewart, Chip, Koster, Jan, Versteeg, Rogier, van Oudenaarden, Alexander, Saez-Rodriguez, Julio, Vries, Robert G.J., Getz, Gad, Wessels, Lodewyk, Stratton, Michael R., McDermott, Ultan, Meyerson, Matthew, Garnett, Mathew J., Clevers, Hans

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Integrated cross-study datasets of genetic dependencies in cancer von Pacini, Clare, Dempster, Joshua M., Boyle, Isabella, Gonçalves, Emanuel, Najgebauer, Hanna, Karakoc, Emre, van der Meer, Dieudonne, Barthorpe, Andrew, Lightfoot, Howard, Jaaks, Patricia, McFarland, James M., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco

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A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds von Bruna, Alejandra, Rueda, Oscar M., Greenwood, Wendy, Batra, Ankita Sati, Callari, Maurizio, Batra, Rajbir Nath, Pogrebniak, Katherine, Sandoval, Jose, Cassidy, John W., Tufegdzic-Vidakovic, Ana, Sammut, Stephen-John, Jones, Linda, Provenzano, Elena, Baird, Richard, Eirew, Peter, Hadfield, James, Eldridge, Matthew, McLaren-Douglas, Anne, Barthorpe, Andrew, Lightfoot, Howard, O’Connor, Mark J., Gray, Joe, Cortes, Javier, Baselga, Jose, Marangoni, Elisabetta, Welm, Alana L., Aparicio, Samuel, Serra, Violeta, Garnett, Mathew J., Caldas, Carlos

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Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells von Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena J, Lightfoot, Howard, Forbes, Simon, Bindal, Nidhi, Beare, Dave, Smith, James A, Thompson, I Richard, Ramaswamy, Sridhar, Futreal, P Andrew, Haber, Daniel A, Stratton, Michael R, Benes, Cyril, McDermott, Ultan, Garnett, Mathew J

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Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer von Garcia-Alonso, Luz, Iorio, Francesco, Matchan, Angela, Fonseca, Nuno, Jaaks, Patricia, Peat, Gareth, Pignatelli, Miguel, Falcone, Fiammetta, Benes, Cyril H, Dunham, Ian, Bignell, Graham, McDade, Simon S, Garnett, Mathew J, Saez-Rodriguez, Julio

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Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets von Dwane, Lisa, Behan, Fiona M, Gonçalves, Emanuel, Lightfoot, Howard, Yang, Wanjuan, van der Meer, Dieudonne, Shepherd, Rebecca, Pignatelli, Miguel, Iorio, Francesco, Garnett, Mathew J

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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics von Li, Xiaodun, Francies, Hayley E., Secrier, Maria, Perner, Juliane, Miremadi, Ahmad, Galeano-Dalmau, Núria, Barendt, William J., Letchford, Laura, Leyden, Genevieve M., Goffin, Emma K., Barthorpe, Andrew, Lightfoot, Howard, Chen, Elisabeth, Gilbert, James, Noorani, Ayesha, Devonshire, Ginny, Bower, Lawrence, Grantham, Amber, MacRae, Shona, Grehan, Nicola, Wedge, David C., Fitzgerald, Rebecca C., Garnett, Mathew J.

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Cell Model Passports—a hub for clinical, genetic and functional datasets of preclinical cancer models von van der Meer, Dieudonne, Barthorpe, Syd, Yang, Wanjuan, Lightfoot, Howard, Hall, Caitlin, Gilbert, James, Francies, Hayley E, Garnett, Mathew J

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SLFN11 informs on standard of care and novel treatments in a wide range of cancer models von Winkler, Claudia, Armenia, Joshua, Jones, Gemma N., Tobalina, Luis, Sale, Matthew J., Petreus, Tudor, Baird, Tarrion, Serra, Violeta, Wang, Anderson T., Lau, Alan, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Pierce, Andrew J., O’Connor, Mark J., Leo, Elisabetta

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Drug Sensitivity Assays of Human Cancer Organoid Cultures von Francies, Hayley E., Barthorpe, Andrew, McLaren-Douglas, Anne, Barendt, William J., Garnett, Mathew J.

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Combinatorial CRISPR screen identifies fitness effects of gene paralogues von Thompson, Nicola A., Ranzani, Marco, van der Weyden, Louise, Iyer, Vivek, Offord, Victoria, Droop, Alastair, Behan, Fiona, Gonçalves, Emanuel, Speak, Anneliese, Iorio, Francesco, Hewinson, James, Harle, Victoria, Robertson, Holly, Anderson, Elizabeth, Fu, Beiyuan, Yang, Fengtang, Zagnoli-Vieira, Guido, Chapman, Phil, Del Castillo Velasco-Herrera, Martin, Garnett, Mathew J., Jackson, Stephen P., Adams, David J.

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Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies von Eduati, Federica, Jaaks, Patricia, Wappler, Jessica, Cramer, Thorsten, Merten, Christoph A, Garnett, Mathew J, Saez‐Rodriguez, Julio

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Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy von Picco, Gabriele, Cattaneo, Chiara M, van Vliet, Esmée J, Crisafulli, Giovanni, Rospo, Giuseppe, Consonni, Sarah, Vieira, Sara F, Rodríguez, Iñigo Sánchez, Cancelliere, Carlotta, Banerjee, Ruby, Schipper, Luuk J, Oddo, Daniele, Dijkstra, Krijn K, Cinatl, Jindrich, Michaelis, Martin, Yang, Fengtang, Di Nicolantonio, Federica, Sartore-Bianchi, Andrea, Siena, Salvatore, Arena, Sabrina, Voest, Emile E, Bardelli, Alberto, Garnett, Mathew J

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CoRe: a robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens von Vinceti, Alessandro, Karakoc, Emre, Pacini, Clare, Perron, Umberto, De Lucia, Riccardo Roberto, Garnett, Mathew J, Iorio, Francesco

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