QT PRODACT: In Vivo QT Assay With a Conscious Monkey for Assessment of the Potential for Drug-Induced QT Interval Prolongation von Ando, Kentaro, Hombo, Toshiyasu, Kanno, Akihiro, Ikeda, Hironobu, Imaizumi, Masakazu, Shimizu, Noritsugu, Sakamoto, Kengo, Kitani, Shin-ichi, Yamamoto, Yoshinori, Hizume, Shingo, Nakai, Keiko, Kitayama, Tetsuya, Yamamoto, Keiji

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DIFFERENCE OF THE DRUG-RESPONSES BETWEEN THE ISOLATED ANAL INNER SPHINCTER AND RECTAL SMOOTH MUSCLES IN THE RAT von Katoh, Atsuko, Imaizumi, Masakazu, Atai, Hiroshi, Nishi, Katsuhide

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P3-146 An Animal Model for Measurements of Gastro-intestinal Peristaltic Movements and Effects of Various Drugs in Conscious, un-restricted Dogs for 24 hours von Atsuko Katoh, Kazuaki Sasaki, Seiichi Katayama, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi

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Study on measurement of internal anal sphincter movement in dogs (application as evaluation method on defecation disorder)-2nd report von Sasaki, Kazuaki, Imaizumi, Masakazu, Katayama, Seiiti, Harada, Keiko, Nishi, Katsuhide

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EVALUATION OF IMIPRAMINE ON HEART: FROM IN VITRO ( IKr, INa, AND APD) TO IN VIVO (TELEMETRY ECG) von Yu, Wenge, Imaizumi, Masakazu, Sasaki, Kazuaki, Inui, Tatsumi, Watanabe, Naoki, Atai, Hiroshi, Iizuka, Hiromi, Nishi, Katsuhide

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A Further study on evaluation of drugs inducing QT-interval prolongation by ECG recorded from the isolated guinea-pig perfused heart paced at the constant heart rate von Atsuko Kato, Masakazu Imaizumi, Hiroshi Atai, Hiromi lizuka, Katsuhide Nishi

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P3J10-5 Effects of transport stress on plasma stress hormone levels in cynomolgus monkeys von Hiroizumi Yamanaka, Junko Hangai, Kazuaki Sasaki, Masahiro Nasu, Seiich Katayama, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi

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Effects of prednisolone on adriamycin-induced nephropathy in rats von Yamazawa, Takumi, Ma, Cheng Jun, Nakaoka, Kikuyo, Imaizumi, Masakazu, Morizumi, Kousuke, Katayama, Seiichi, Hironaka, Naoyuki, Nishi, Katsuhide

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Study on measurement of internal anal sphincter movement in dog (application as evaluation method on defecation disorder) von Sasaki, Kazuaki, Harada, Keiko, Nakamura, Yasuo, Imaizumi, Masakazu, Katayama, Seiichi, Nishi, Katsuhide

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P2L-P17-6 Evaluation of intravesical pressure and urinary function in a newly introduced cystitis model in female dogs von Yasuo Nakamura, Kazuaki Sasaki, Hiroizumi Yamanaka, Ryouji Mizumachi, Masakazu Imaizumi, Hiroshi Atai, Katuhide Nishi

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P3-071 Recording mono-phasic action potentials(MAP)from the suface of the anesthetized guinea-pig heart electrically paced at a constant rate to evaluate drugs inducing QT-interval... von Keiko Azuma, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi

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P2L-19 Effects of verapamil on Ca channel in the HH-8 cell---A useful tool for screening of newly developed compounds von Wenge Yu, Naoki Watanabe, Ami kitazato, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi

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P2K-13 Cystometry in Unanesthetized and Unrestrained Female Dogs von Yasuo Nakamura, Norio Odagiri, Kazuaki Sasaki, Ryoji Mizumachi, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka

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P1K-24 Simaltaneous evaluation of the respiratory, cardiovascular and central nervous systems in the mokey in an unrestrained Whole-Body Plethysmography (WBP) von Kazuaki Sasaki, Yasuo Nakamura, Norio Odagiri, Masakazu Imaizumi, Chengjun Ma, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi

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P1-178 Measurement of Urethral Pressure in Unanesthetized Female Dogs von Kazuaki Sasaki, Masakazu Imaizumi, Yasuo Nakamur, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi

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P1-186 Antitumor effect of S-1 in combination with COX-2 inhibitor(celecoxib)in a gastric cancer orthotopic model in nude mice von Zhe Sun, Kana Kimura, Takashi Morikawa, Keisuke Taniguchi, Masakazu Imaizumi, Hiroshi Atai

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P2M-37 Effects of imipramine on lkr of hERG/HEK293, lNa of isolated ventricular cells, and action potential of papillary muscle of the guinea pig von Wen-ge Yu, Tatsumi Inui, Kana Kimura, Naoki Watanabe, Eri Nuguchi, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nshi

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Evaluation of drugs inducing QT-interval prolongation by ECG recorded from the isolated guinea-pig heart perfused with the Langendorff's method von Atsuko Katoh, Tatsumi Inui, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi

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MODULATION OF HERG CURRENTS BY DRUGS von Masakazu Imaizumi, Wen-Ge Yu, Hisako Moriyama, Harumi Hayashida, Hiroshi Atai, Hiromi Iizuka, Kastuhide Nishi

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QT PRODACT：In Vivo QT Assay With a Conscious Monkey for Assessment of the Potential for Drug-Induced QT Interval Prolongation von Kentaro Ando, Toshiyasu Hombo, Akihiro Kanno, Hironobu Ikeda, Masakazu Imaizumi, Noritsugu Shimizu, Kengo Sakamoto, Shin-ichi Kitani, Yoshinori Yamamoto, Shingo Hizume, Keiko Nakai, Tetsuya Kitayama, Keiji Yamamoto

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