Clinical Utility of the Combined Positive Score for Programmed Death Ligand-1 Expression and the Approval of Pembrolizumab for Treatment of Gastric Cancer von Kulangara, Karina, Zhang, Nancy, Corigliano, Ellie, Guerrero, Lindsay, Waldroup, Stephanie, Jaiswal, Dipeshkumar, Ms, Malinka Jansson, Shah, Supriya, Hanks, Debra, Wang, Jiangdian, Lunceford, Jared, Savage, Mary J, Juco, Jonathan, Emancipator, Kenneth

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Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies von Selnick, Harold G, Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B, Ballard, Jeanine E, Marcus, Jacob, Klein, Daniel J, Wang, Xiaohai, Pearson, Michelle, Savage, Mary J, Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J, Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L, McEachern, Ernest J

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Pembrolizumab alone or in combination with chemotherapy as first-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma: results from the phase... von Bang, Yung-Jue, Kang, Yoon-Koo, Catenacci, Daniel V., Muro, Kei, Fuchs, Charles S., Geva, Ravit, Hara, Hiroki, Golan, Talia, Garrido, Marcelo, Jalal, Shadia I., Borg, Christophe, Doi, Toshihiko, Yoon, Harry H., Savage, Mary J., Wang, Jiangdian, Dalal, Rita P., Shah, Sukrut, Wainberg, Zev A., Chung, Hyun Cheol

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Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy von Wang, Xiaohai, Smith, Karen, Pearson, Michelle, Hughes, Anna, Cosden, Mali L, Marcus, Jacob, Hess, J Fred, Savage, Mary J, Rosahl, Thomas, Smith, Sean M, Schachter, Joel B, Uslaner, Jason M

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First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 s... von Balar, Arjun V, Castellano, Daniel, O'Donnell, Peter H, Grivas, Petros, Vuky, Jacqueline, Powles, Thomas, Plimack, Elizabeth R, Hahn, Noah M, de Wit, Ronald, Pang, Lei, Savage, Mary J, Perini, Rodolfo F, Keefe, Stephen M, Bajorin, Dean, Bellmunt, Joaquim

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AMPA Receptor Downscaling at the Onset of Alzheimer's Disease Pathology in Double Knockin Mice von Chang, Eric H., Savage, Mary J., Flood, Dorothy G., Thomas, Justin M., Levy, Robert B., Mahadomrongkul, Veeravan, Shirao, Tomoaki, Aoki, Chiye, Huerta, Patricio T.

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Long-Term Outcomes in KEYNOTE-052: Phase II Study Investigating First-Line Pembrolizumab in Cisplatin-Ineligible Patients With Locally Advanced or Metastatic Urothelial Cancer von Vuky, Jacqueline, Balar, Arjun V., Castellano, Daniel, O'Donnell, Peter H., Grivas, Petros, Bellmunt, Joaquim, Powles, Thomas, Bajorin, Dean, Hahn, Noah M., Savage, Mary J., Fang, Xiao, Godwin, James Luke, Frenkl, Tara L., Moreno, Blanca Homet, de Wit, Ronald, Plimack, Elizabeth R.

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Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression von Stivers, Peter J, Harmonay, Lauren, Hicks, Alexandra, Mehmet, Huseyin, Morris, Melody, Robinson, Gain M, Strack, Peter R, Savage, Mary J, Zaller, Dennis M, Zwierzynski, Izabela, Brandish, Philip E

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A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid von Savage, Mary J, Kalinina, Juliya, Wolfe, Abigail, Tugusheva, Katherine, Korn, Rachel, Cash-Mason, Tanesha, Maxwell, Jill W, Hatcher, Nathan G, Haugabook, Sharie J, Wu, Guoxin, Howell, Bonnie J, Renger, John J, Shughrue, Paul J, McCampbell, Alexander

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Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease von Savage, Mary J., Gingrich, Diane E.

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Evaluation of Cynomolgus Monkeys for the Identification of Endogenous Biomarkers for Hepatic Transporter Inhibition and as a Translatable Model to Predict Pharmacokinetic Interacti... von Chu, Xiaoyan, Shih, Shian-Jiun, Shaw, Rachel, Hentze, Hannes, Chan, Grace H, Owens, Karen, Wang, Shubing, Cai, Xiaoxin, Newton, Deborah, Castro-Perez, Jose, Salituro, Gino, Palamanda, Jairam, Fernandis, Aaron, Ng, Choon Keow, Liaw, Andy, Savage, Mary J, Evers, Raymond

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Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease von Wu, Guoxin, Sankaranarayanan, Sethu, Wong, Jacky, Tugusheva, Katherine, Michener, Maria S., Shi, Xiaoping, Cook, Jacquelynn J., Simon, Adam J., Savage, Mary J.

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Extending a systems model of the APP pathway: Separation of β- and γ-secretase sequential cleavage steps of APP von van Maanen, Eline T S, van Steeg, Tamara S, Ahsman, Maurice, Michener, Maria S, Savage, Mary J, Kennedy, Matthew E, Kleijn, Huub J, Stone, Julie A, Danhof, Meindert

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CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition von Dobrowolska, Justyna A, Michener, Maria S, Wu, Guoxin, Patterson, Bruce W, Chott, Robert, Ovod, Vitaliy, Pyatkivskyy, Yuriy, Wildsmith, Kristin R, Kasten, Tom, Mathers, Parker, Dancho, Mandy, Lennox, Christina, Smith, Brad E, Gilberto, David, McLoughlin, Debra, Holder, Daniel J, Stamford, Andrew W, Yarasheski, Kevin E, Kennedy, Matthew E, Savage, Mary J, Bateman, Randall J

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Systems Pharmacology Analysis of the Amyloid Cascade after β-Secretase Inhibition Enables the Identification of an Aβ42 Oligomer Pool von van Maanen, Eline M T, van Steeg, Tamara J, Michener, Maria S, Savage, Mary J, Kennedy, Matthew E, Kleijn, Huub Jan, Stone, Julie A, Danhof, Meindert

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Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition von Savage, Mary J, Lin, Yin-Guo, Ciallella, John R, Flood, Dorothy G, Scott, Richard W

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Pyroglutamate-Modified Amyloid-β Protein Demonstrates Similar Properties in an Alzheimer's Disease Familial Mutant Knock-In Mouse and Alzheimer's Disease Brain von Wu, Guoxin, Miller, Ronald A., Connolly, Brett, Marcus, Jacob, Renger, John, Savage, Mary J.

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A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease von Zhao, Xuemei, Kang, John, Svetnik, Vladimir, Warden, Donald, Wilcock, Gordon, David Smith, A, Savage, Mary J, Laterza, Omar F

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A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition von Flood, Dorothy G, Lin, Yin-Guo, Lang, Diane M, Trusko, Stephen P, Hirsch, James D, Savage, Mary J, Scott, Richard W, Howland, David S

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Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex von Wu, Guoxin, Sankaranarayanan, Sethu, Hsieh, Sidney H.-K., Simon, Adam J., Savage, Mary J.

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