Development and internal validation of a predictive nomogram of progression-free survival in well-differentiated stage IV gastroenteropancreatic neuroendocrine tumours treated with... von Garcia-Carbonero, R., Alonso, V., Capdevila, J., Sanchez Canovas, M., Alonso, T., Benavent, M., Custodio, A., Crespo Herrero, G., Lopez, C., Hernando, J., Riesco Martinez, M.C., Escudero, P., Gallego Plazas, J., Marazuela, M., Diaz, J.A., Llanos-Munoz, M., La Casta, A., Percovich, J.C., Jimenez-Fonseca, P., Carmona-Bayonas, A.

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The role of antiangiogenic therapy in advanced gastro-esophageal cancer: a systematic review and meta-analysis von Riesco-Martinez, M.C., Díaz-Serrano, A., Gomez-Martin, C., Alfonso, J. Adeva, Cabrera, E. Sabater, Garcia-Carbonero, R.

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Proof of concept clinical study by US-guided intratumor injection of VCN-01, an oncolytic adenovirus expressing hyaluronidase in patients with pancreatic cancer von Hidalgo, M., Bazan-Peregrino, M., Laquente, B., Gallego, R Alvarez, Mato-Berciano, A., Giménez-Alejandre, M., Maliandi, V., Martinez, M C Riesco, Moreno, R., Morell, M., Perez-Carreras, M., Gornals, J., Prados, S., Capella, G., Alemany, R., Salazar, R., Blasi, E., Blasco, C., Cascallo, M., Garcia-Carbonero, R.

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459P - Proof of concept clinical study by US-guided intratumor injection of VCN-01, an oncolytic adenovirus expressing hyaluronidase in patients with pancreatic cancer von Hidalgo, M., Bazan-Peregrino, M., Laquente, B., Gallego, R Alvarez, Mato-Berciano, A., Giménez-Alejandre, M., Maliandi, V., Martinez, M C Riesco, Moreno, R., Morell, M., Perez-Carreras, M., Gornals, J., Prados, S., Capella, G., Alemany, R., Salazar, R., Blasi, E., Blasco, C., Cascallo, M., Garcia-Carbonero, R.

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459PProof of concept clinical study by US-guided intratumor injection of VCN-01, an oncolytic adenovirus expressing hyaluronidase in patients with pancreatic cancer von Hidalgo, M, Bazan-Peregrino, M, Laquente, B, Gallego, R Alvarez, Mato-Berciano, A, Giménez-Alejandre, M, Maliandi, V, Martinez, M C Riesco, Moreno, R, Morell, M, Perez-Carreras, M, Gornals, J, Prados, S, Capella, G, Alemany, R, Salazar, R, Blasi, E, Blasco, C, Cascallo, M, Garcia-Carbonero, R

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710PSystemic administration of the hyaluronidase-expressing oncolytic adenovirus VCN-01 in patients with advanced or metastatic pancreatic cancer: First-in-human clinical trial von Garcia-Carbonero, R, Gil Martín, M, Alvarez Gallego, R, Macarulla Mercade, T, Riesco Martinez, M C, Guillen-Ponce, C, Vidal, N, Real, F X, Moreno, R, Maliandi, V, Mato-Berciano, A, Bazan-Peregrino, M, Capella, G, Alemany, R, Blasi, E, Blasco, C, Cascallo, M, Salazar, R

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518PSILVELUL project: Immunohistochemical panel analyses as potential predictive and prognostic factors in pancreatic neuroendocrine tumours (PanNET) treated with CAPTEM or everoli... von De Jesus-Acosta, A, Crespo Herrero, G, Gómez-Dorronsoro, M L, Alonso, V, Riesco Martinez, M C, Custodio, A, Lopez, C, Benavent, M, Carmona Bayonas, A, Jimenez-Fonseca, P, Llanos, M, López De San Vicente, B, Arrazubi Arrula, V, Grandez, R, González-Borja, I, Goñi, S, Arozarena, I, Baretti, M, Viudez, A

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1315PDevelopment and internal validation of a predictive nomogram of progression-free survival in well-differentiated stage IV gastroenteropancreatic neuroendocrine tumours treated... von Garcia-Carbonero, R, Alonso, V, Capdevila, J, Sanchez Canovas, M, Alonso, T, Benavent, M, Custodio, A, Crespo Herrero, G, Lopez, C, Hernando, J, Riesco Martinez, M C, Escudero, P, Gallego Plazas, J, Marazuela, M, Diaz, J A, Llanos-Munoz, M, La Casta, A, Percovich, J C, Jimenez-Fonseca, P, Carmona-Bayonas, A

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Prognostic relevance of Src activation in stage II-III colon cancer von Perez, Julia Martinez, MD, Lopez-Calderero, Iker, MD, Saez, Carmen, PhD, Benavent, Marta, MD, Limon, Maria L., MD, Gonzalez-Exposito, Reyes, MD, Soldevilla, B., PhD, Riesco-Martinez, Maria C., MD, Salamanca, Javier, MD, Carnero, Amancio, PhD, Garcia-Carbonero, Rocio, MD, PhD

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Abstract P1-14-05: Is there a correlation between androgen receptor (AR) expression in metastatic breast cancer (MBC) ER+/Her2- and response to anti-estrogen treatment? von Riesco Martínez, MC, Hanna, W, Ghorab, Z, Warner, E

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Factors enhancing fish sperm quality and emerging tools for sperm analysis von Cabrita, E., Martínez-Páramo, S., Gavaia, P.J., Riesco, M.F., Valcarce, D.G., Sarasquete, C., Herráez, M.P., Robles, V.

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Cost–benefit analysis of funding smoking cessation before surgery von Jiménez‐Ruiz, C. A., Martín, V., Alsina‐Restoy, X., Granda‐Orive, J. I., Higes‐Martínez, E., García‐Rueda, M., Genovés‐Crespo, M., López‐García, C., Lorza‐Blasco, J. J., Márquez, F. L., Ramos‐Pinedo, Á., Riesco‐Miranda, J. A., Signes‐Costa, J., Solano‐Reina, S., Vaquero‐Lozano, P., Rejas, J.

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Randomized phase II trial of FOLFIRI-panitumumab compared with FOLFIRI alone in patients with RAS wild-type circulating tumor DNA metastatic colorectal cancer beyond progression to... von Aparicio, Jorge, Virgili Manrique, Anna C., Capdevila, Jaume, Muñoz Boza, Félix, Galván, Patricia, Richart, Paula, Oliveres, Helena, Páez, David, Hernando, Jorge, Serrano, Sara, Vera, Ruth, Hernandez-Yagüe, Xavier, Gallego, Rafael Álvarez, Riesco-Martinez, M. Carmen, García de Albeniz, Xavier, Maurel, Joan

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Design and application of a 23-gene panel by next-generation sequencing for inherited coagulation bleeding disorders von Bastida, J. M., del Rey, M., Lozano, M. L., Sarasquete, M. E., Benito, R., Fontecha, M. E., Fisac, R., García-Frade, L. J., Aguilar, C., Martínez, M. P., Pardal, E., Aguilera, C., Pérez, B., Ramos, R., Cardesa, M. R., Martin-Antorán, J. M., Silvestre, L. A., Cebeira, M. J., Bermejo, N., Riesco, S., Mendoza, M. C., García-Sanz, R., González-Díaz, M., Hernández-Rivas, J. M., González-Porras, J. R.

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151P Enhanced pharmacodynamic effects upon combination of cibisatamab and FAP-4-1BBL in 3L+ mMSS CRC patients von Melero, I., Tanos, T., Heichinger, C., Davydov, I., Boehnke, A., Kumpesa, N., Ooi, C., Karanikas, V., Cannarile, M., Argota, I. Baraibar, Garcia, M. Martinez, Garcia, V. Moreno, Qvortrup, C., Kim, T.W., Beom, S-H., Van Dongen, M.G., Calvo, E., Martinez, M.C. Riesco, Thistlethwaite, F., Woodcock, V.K.

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600TiP A randomized blinded phase II study of ompenaclid (RGX-202-01) vs placebo in combination with FOLFIRI plus bevacizumab (BEV) in patients (pts) with previously treated RAS mu... von Elez Fernandez, M.E., Rosello Keranen, S., Paez, D., Jiménez Castro, J., Rivera Herrero, F., Ruiz-Casado, A., Riesco Martinez, M.C., Montagut Viladot, C., Coupez, D., Ducreux, M.P., Loly, C., Martin-Babau, J., Prenen, H., van den Eynde, M., Borg, C., Cuyle, P-J., de Haar-Holleman, A., Raimbourg, J., Bechar, N., Tabernero, J.

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Budgetary impact analysis on funding smoking-cessation drugs in patients with COPD in Spain von Jiménez-Ruiz, Carlos A, Solano-Reina, Segismundo, Signes-Costa, Jaime, de Higes-Martinez, Eva, Granda-Orive, José I, Lorza-Blasco, José J, Riesco-Miranda, Juan A, Altet-Gomez, Neus, Barrueco, Miguel, Oyagüez, Itziar, Rejas, Javier

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Frequency and prognostic impact of acute kidney injury in patients with acute pulmonary embolism. Data from the RIETE registry von Murgier, Martin, Bertoletti, Laurent, Darmon, Michael, Zeni, Fabrice, Valle, Reina, Del Toro, Jorge, Llamas, Pilar, Mazzolai, Lucia, Villalobos, Aurora, Monreal, Manuel

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253P International real-world study of total neoadjuvant therapy (TNT) for locally advanced rectal cancer (LARC) von Audisio, A., Velenik, V., Meillat, H., Ruiz, E., Riesco Martinez, M.C., Suarez, J., Dekervel, J., Carvalho, C., Randrian, V., Kirac, I., Hernando Cubero, J., Artaç, M., O'Connor, J.M.R., Waldhorn, I., Braam, P., Shamseddine, A.I., Saad, E.D., Deltuvaite-Thomas, V., Staggs, V., Sclafani, F.

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595P The DUREC trial: Durvalumab plus total neoadjuvant therapy in locally advanced rectal cancer - a multicenter, single-arm, phase II study (GEMCAD-1703) von Capdevila Castillon, J., Alonso, V., Macias Declara, I., Melian, M., Gallego Plazas, J., Vera, R., Riesco Martinez, M.C., Maurel, J., Grana Suarez, B., Hernando, J., Garcia Alvarez, A., Navalpotro, B., Soler Gonzalez, G., Polo, E., Garcia Fadrique, A., Espin, E., Fernandez Martos, C., Villacampa Javierre, G., Losa, F.

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