Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia von Roch, Catherine, Bergamini, Giorgio, Steiner, Michel A., Clozel, Martine

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Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells von Gatfield, John, Mueller Grandjean, Celia, Sasse, Thomas, Clozel, Martine, Nayler, Oliver

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Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension von Asaki, Tetsuo, Kuwano, Keiichi, Morrison, Keith, Gatfield, John, Hamamoto, Taisuke, Clozel, Martine

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Mechanisms of ET-1-induced Endothelial Dysfunction von Iglarz, Marc, Clozel, Martine

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The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Ant... von Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas

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Promotion of sleep by targeting the orexin system in rats, dogs and humans von Jenck, François, Brisbare-Roch, Catherine, Dingemanse, Jasper, Koberstein, Ralf, Hoever, Petra, Aissaoui, Hamed, Flores, Susan, Mueller, Celia, Nayler, Oliver, van Gerven, Joop, de Haas, Sanne L, Hess, Patrick, Qiu, Changbin, Buchmann, Stephan, Scherz, Michael, Weller, Thomas, Fischli, Walter, Clozel, Martine

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The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation von Piali, Luca, Froidevaux, Sylvie, Hess, Patrick, Nayler, Oliver, Bolli, Martin H, Schlosser, Eva, Kohl, Christopher, Steiner, Beat, Clozel, Martine

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CRISPR‐Cas9‐modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based... von Ng, Caroline L., Siciliano, Giulia, Lee, Marcus C. S., de Almeida, Mariana J., Corey, Victoria C., Bopp, Selina E., Bertuccini, Lucia, Wittlin, Sergio, Kasdin, Rachel G., Le Bihan, Amélie, Clozel, Martine, Winzeler, Elizabeth A., Alano, Pietro, Fidock, David A.

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Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery von Morrison, Keith, Studer, Rolf, Ernst, Roland, Haag, Franck, Kauser, Katalin, Clozel, Martine

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Endothelin research and the discovery of macitentan for the treatment of pulmonary arterial hypertension von Clozel, Martine

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Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension von Iglarz, Marc, Bossu, Alexandre, Wanner, Daniel, Bortolamiol, Céline, Rey, Markus, Hess, Patrick, Clozel, Martine

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling von Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J, Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo-Benito, Francisco Javier, Gnädig, Nina F, Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J, Ng, Caroline L, Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W, Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N, Weller, Thomas, Fischli, Walter, Fidock, David A, Clozel, Martine, Wittlin, Sergio

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Development of macitentan for the treatment of pulmonary arterial hypertension von Selej, Mona, Romero, Alain J., Channick, Richard N., Clozel, Martine

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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator von Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat

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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes von You, Sylvaine, Piali, Luca, Kuhn, Chantal, Steiner, Beat, Sauvaget, Virginia, Valette, Fabrice, Clozel, Martine, Bach, Jean-François, Chatenoud, Lucienne

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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension von Iglarz, Marc, Landskroner, Kyle, Bauer, Yasmina, Vercauteren, Magali, Rey, Markus, Renault, Berengère, Studer, Rolf, Vezzali, Enrico, Freti, Diego, Hadana, Hakim, Schläpfer, Manuela, Cattaneo, Christophe, Bortolamiol, Céline, Weber, Edgar, Whitby, Brian R, Delahaye, Stéphane, Wanner, Daniel, Steiner, Pauline, Nayler, Oliver, Hess, Patrick, Clozel, Martine

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Benefits of dual endothelin receptor antagonists: Mechanisms of action, current studies, and future directions von Clozel, Martine

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Complete Resolution of Clinical Signs and Synergism of the Combination Ponesimod-dimethyl Fumarate in Rat Models of Multiple Sclerosis (P2.411) von Pouzol, Laetitia, Brian, Paul, Clozel, Martine

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A Causative Role for Redox Cycling of Myoglobin and Its Inhibition by Alkalinization in the Pathogenesis and Treatment of Rhabdomyolysis-induced Renal Failure von Moore, Kevin P., Holt, Steve G., Patel, Rakesh P., Svistunenko, Dimitri A., Zackert, William, Goodier, David, Reeder, Brandon. J., Clozel, Martine, Anand, Radhi, Cooper, Christopher E., Morrow, Jason D., Wilson, Michael T., Darley-Usmar, Victor, Roberts, L. Jackson

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Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention von Vercauteren, Magali, Trensz, Frederic, Pasquali, Anne, Cattaneo, Christophe, Strasser, Daniel S., Hess, Patrick, Iglarz, Marc, Clozel, Martine

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