Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function von Lee, Young-hee, Martin-Orozco, Natalia, Zheng, Peilin, Li, Jing, Zhang, Peng, Tan, Haidong, Park, Hyun Jung, Jeong, Mira, Chang, Seon Hee, Kim, Byung-Seok, Xiong, Wei, Zang, Wenjuan, Guo, Li, Liu, Yang, Dong, Zhong-jun, Overwijk, Willem W, Hwu, Patrick, Yi, Qing, Kwak, Larry, Yang, Zhiying, Mak, Tak W, Li, Wei, Radvanyi, Laszlo G, Ni, Ling, Liu, Dongfang, Dong, Chen

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Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells von Martin-Orozco, Natalia, Chung, Yeonseok, Chang, Seon Hee, Wang, Yi-Hong, Dong, Chen

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Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study von Reiter, Lawrence, Greffrath, Johann, Zidel, Bian, Ostrowski, Mario, Gommerman, Jennifer, Madhi, Shabir A., Tran, Richard, Martin-Orozco, Natalia, Panicker, Rajesh Krishnan Gopalakrishna, Cooper, Curtis, Pastrak, Aleksandra

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CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells von Yasutomi, Motoko, Christiaansen, Allison F, Imai, Naoko, Martin-Orozco, Natalia, Forst, Christian V, Chen, Gang, Ueno, Hideki

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Phase I randomized, observer-blinded, placebo-controlled study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B von Martin-Orozco, Natalia, Vale, Noah, Mihic, Alan, Amor, Talya, Reiter, Lawrence, Arita, Yuko, Samson, Reuben, Hu, Queenie, Gingras, Anne-Claude, Sorenson, Bradley Thomas, Marcusson, Eric Gates, Patel, Piyush

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T-cell tolerance or function is determined by combinatorial costimulatory signals von Nurieva, Roza, Thomas, Sunil, Nguyen, Thang, Martin-Orozco, Natalia, Wang, Ying, Kaja, Murali-Krishna, Yu, Xue-Zhong, Dong, Chen

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Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B von Liu, Jun, Budylowski, Patrick, Samson, Reuben, Griffin, Bryan D, Babuadze, Giorgi, Rathod, Bhavisha, Colwill, Karen, Abioye, Jumai A, Schwartz, Jordan A, Law, Ryan, Yip, Lily, Ahn, Sang Kyun, Chau, Serena, Naghibosadat, Maedeh, Arita, Yuko, Hu, Queenie, Yue, Feng Yun, Banerjee, Arinjay, Hardy, W Rod, Mossman, Karen, Mubareka, Samira, Kozak, Robert A, Pollanen, Michael S, Martin Orozco, Natalia, Gingras, Anne-Claude, Marcusson, Eric G, Ostrowski, Mario A

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MKP-1 Is Necessary for T Cell Activation and Function von Zhang, Yongliang, Reynolds, Joseph M., Chang, Seon Hee, Martin-Orozco, Natalia, Chung, Yeonseok, Nurieva, Roza I., Dong, Chen

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Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice von Lamothe, Betty, Lai, Yunju, Hur, Lana, Orozco, Natalia Martin, Wang, Jing, Campos, Alejandro D, Xie, Min, Schneider, Michael D, Lockworth, Cynthia R, Jakacky, Jared, Tran, Diep, Ho, Michael, Dawud, Sity, Dong, Chen, Lin, Hui-Kuan, Hu, Peter, Estrov, Zeev, Bueso-Ramos, Carlos E, Darnay, Bryant G

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Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice von Zou, Liangxing, Mendez, Felipe, Martin-Orozco, Natalia, Peterson, Erik J

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New battlefields for costimulation von Martin-Orozco, Natalia, Dong, Chen

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IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients von Sim, Geok Choo, Martin-Orozco, Natalia, Jin, Lei, Yang, Yan, Wu, Sheng, Washington, Edwina, Sanders, Deborah, Lacey, Carol, Wang, Yijun, Vence, Luis, Hwu, Patrick, Radvanyi, Laszlo

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T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity von Martin-Orozco, Natalia, Muranski, Pawel, Chung, Yeonseok, Yang, Xuexian O., Yamazaki, Tomohide, Lu, Sijie, Hwu, Patrick, Restifo, Nicholas P., Overwijk, Willem W., Dong, Chen

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Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia von Touret, Nicolas, Martin-Orozco, Natalia, Paroutis, Paul, Furuya, Wendy, Lam-Yuk-Tseung, Steven, Forbes, John, Gros, Philippe, Grinstein, Sergio

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Bcl6 expression specifies the T follicular helper cell program in vivo von Liu, Xindong, Yan, Xiaowei, Zhong, Bo, Nurieva, Roza I, Wang, Aibo, Wang, Xiaohu, Martin-Orozco, Natalia, Wang, Yihong, Chang, Seon Hee, Esplugues, Enric, Flavell, Richard A, Tian, Qiang, Dong, Chen

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T cells and T cell tumors efficiently generate antigen-specific cytotoxic T cell immunity when modified with an NKT ligand von Chung, Yeonseok, Lee, Young-Hee, Zhang, Yongliang, Martin-Orozco, Natalia, Yamazaki, Tomohide, Zhou, Dapeng, Kang, Chang-Yuil, Hwu, Patrick, Kwak, Larry W., Dong, Chen

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CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells von Yamazaki, Tomohide, Yang, Xuexian O, Chung, Yeonseok, Fukunaga, Atsushi, Nurieva, Roza, Pappu, Bhanu, Martin-Orozco, Natalia, Kang, Hong Soon, Ma, Li, Panopoulos, Athanasia D, Craig, Suzanne, Watowich, Stephanie S, Jetten, Anton M, Tian, Qiang, Dong, Chen

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EXTH-15. AN EGFRVIII RNA-LNP VACCINE PROTOTYPE ACHIEVES TUMOUR CLEARANCE IN A GBM MOUSE MODEL von Snelling, Shannon, Nechanitzky, Robert, Lun, Xueqing, Ellestad, Kristofer, Pyczek, Joanna, Olsen, Kirsten, Wu, Yu, Karpov, Yury, Liu, Jun, Gold, Matthew, Menon, Haritha, Tan, Yilin, Krishnan, Rajesh, Mahoney, Douglas, Martin-Orozco, Natalia, Chan, Jennifer A

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Cutting Edge: Programed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens von Martin-Orozco, Natalia, Wang, Yi-Hong, Yagita, Hideo, Dong, Chen

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Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells von MARTIN-OROZCO, Natalia, YUFENG LI, YIJUN WANG, SHIJUAN LIU, HWU, Patrick, LIU, Yong-Jun, CHEN DONG, RADVANYI, Laszlo

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