Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond von Holderfield, Matthew, Deuker, Marian M., McCormick, Frank, McMahon, Martin

Volltext

Good quality end-of life care for people with an intellectual disability: A critical interpretive synthesis protocol von Haigh, Margaret, McCarron, Mary, McCallion, Philip, Pavithra, Pavithra, McMahon, Martin

Volltext

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers von Kinsey, Conan G., Camolotto, Soledad A., Boespflug, Amelie M., Guillen, Katrin P., Foth, Mona, Truong, Amanda, Schuman, Sophia S., Shea, Jill E., Seipp, Michael T., Yap, Jeffrey T., Burrell, Lance D., Lum, David H., Whisenant, Jonathan R., Gilcrease, G. Weldon, Cavalieri, Courtney C., Rehbein, Kaitrin M., Cutler, Stephanie L., Affolter, Kajsa E., Welm, Alana L., Welm, Bryan E., Scaife, Courtney L., Snyder, Eric L., McMahon, Martin

Volltext

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background von Mitra, Devarati, Luo, Xi, Morgan, Ann, Wang, Jin, Hoang, Mai P., Lo, Jennifer, Guerrero, Candace R., Lennerz, Jochen K., Mihm, Martin C., Wargo, Jennifer A., Robinson, Kathleen C., Devi, Suprabha P., Vanover, Jillian C., D’Orazio, John A., McMahon, Martin, Bosenberg, Marcus W., Haigis, Kevin M., Haber, Daniel A., Wang, Yinsheng, Fisher, David E.

Volltext

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies von Lin, Luping, Sabnis, Amit J, Chan, Elton, Olivas, Victor, Cade, Lindsay, Pazarentzos, Evangelos, Asthana, Saurabh, Neel, Dana, Yan, Jenny Jiacheng, Lu, Xinyuan, Pham, Luu, Wang, Mingxue M, Karachaliou, Niki, Cao, Maria Gonzalez, Manzano, Jose Luis, Ramirez, Jose Luis, Torres, Jose Miguel Sanchez, Buttitta, Fiamma, Rudin, Charles M, Collisson, Eric A, Algazi, Alain, Robinson, Eric, Osman, Iman, Muñoz-Couselo, Eva, Cortes, Javier, Frederick, Dennie T, Cooper, Zachary A, McMahon, Martin, Marchetti, Antonio, Rosell, Rafael, Flaherty, Keith T, Wargo, Jennifer A, Bivona, Trever G

Volltext

Phenformin enhances the therapeutic benefit of BRAFⱽ⁶⁰⁰ᴱ inhibition in melanoma von Yuan, Bing, Ito, Koichi, Perez-Lorenzo, Rolando, Del Guzzo, Christina, Lee, Jung Hyun, Shen, Che-Hung, Bosenberg, Marcus W, McMahon, Martin, Cantley, Lewis C, Zheng, Bin

Volltext

Control of Mitotic Spindle Angle by the RAS-Regulated ERK1/2 Pathway Determines Lung Tube Shape von Tang, Nan, Marshall, Wallace F., McMahon, Martin, Metzger, Ross J., Martin, Gail R.

Volltext

PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis von Green, Shon, Trejo, Christy L., McMahon, Martin

Volltext

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer von McFadden, David G, Vernon, Amanda, Santiago, Philip M, Martinez-McFaline, Raul, Bhutkar, Arjun, Crowley, Denise M, McMahon, Martin, Sadow, Peter M, Jacks, Tyler

Volltext

Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis von Charles, Roch-Philippe, Silva, Jillian, Iezza, Gioia, Phillips, Wayne A, McMahon, Martin

Volltext

Abstract 308: Interrogating Goldilocks: Searching for mediators of oncogene overdose in engineered BRAFV600E inhibitor resistant melanoma cells von Pringle, Daphne R., McMahon, Martin

Volltext

Elucidating distinct roles for NF1 in melanomagenesis von Maertens, Ophélia, Johnson, Bryan, Hollstein, Pablo, Frederick, Dennie T, Cooper, Zachary A, Messiaen, Ludwine, Bronson, Roderick T, McMahon, Martin, Granter, Scott, Flaherty, Keith, Wargo, Jennifer A, Marais, Richard, Cichowski, Karen

Volltext

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma von Collisson, Eric A, Trejo, Christy L, Silva, Jillian M, Gu, Shenda, Korkola, James E, Heiser, Laura M, Charles, Roch-Philippe, Rabinovich, Brian A, Hann, Byron, Dankort, David, Spellman, Paul T, Phillips, Wayne A, Gray, Joe W, McMahon, Martin

Volltext

Mortality in residential care facilities for people with disability: a descriptive cross-sectional analysis of statutory notifications in Ireland von McMahon, Martin J, O'Connor, Aisling M, Dunbar, Paul, Delany, Anna, Behan, Laura, Grogan, Carol, Keyes, Laura M

Volltext

Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse von CHARLES, Roch-Philippe, LEZZA, Gioia, AMENDOLA, Elena, DANKORT, David, MCMAHON, Martin

Volltext

AKT1 Activation Promotes Development of Melanoma Metastases von Cho, Joseph H., Robinson, James P., Arave, Rowan A., Burnett, William J., Kircher, David A., Chen, Guo, Davies, Michael A., Grossmann, Allie H., VanBrocklin, Matthew W., McMahon, Martin, Holmen, Sheri L.

Volltext

mTORC1 Activation Blocks BrafV600E-Induced Growth Arrest but Is Insufficient for Melanoma Formation von Damsky, William, Micevic, Goran, Meeth, Katrina, Muthusamy, Viswanathan, Curley, David P., Santhanakrishnan, Manjula, Erdelyi, Ildiko, Platt, James T., Huang, Laura, Theodosakis, Nicholas, Zaidi, M. Raza, Tighe, Scott, Davies, Michael A., Dankort, David, McMahon, Martin, Merlino, Glenn, Bardeesy, Nabeel, Bosenberg, Marcus

Volltext

AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis von Kircher, David A., Trombetti, Kirby A., Silvis, Mark R., Parkman, Gennie L., Fischer, Grant M., Angel, Stephanie N., Stehn, Christopher M., Strain, Sean C., Grossmann, Allie H., Duffy, Keith L., Boucher, Kenneth M., McMahon, Martin, Davies, Michael A., Mendoza, Michelle C., VanBrocklin, Matthew W., Holmen, Sheri L.

Volltext

Incidence and type of restrictive practice use in nursing homes in Ireland von Dunbar, Paul, McMahon, Martin, Durkan, Ciara, Walsh, Kieran A., Keyes, Laura M.

Volltext

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis von Thayer, Sarah P., di Magliano, Marina Pasca, Heiser, Patrick W., Nielsen, Corinne M., Roberts, Drucilla J., Lauwers, Gregory Y., Qi, Yan Ping, Gysin, Stephan, Castillo, Carlos Fernández-del, Yajnik, Vijay, Antoniu, Bozena, McMahon, Martin, Warshaw, Andrew L., Hebrok, Matthias

Volltext