Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205),... von Vaswani, Rishi G, Gehling, Victor S, Dakin, Les A, Cook, Andrew S, Nasveschuk, Christopher G, Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C, Campbell, Robert, Lee, Christina, Cantone, Nico, Cummings, Richard T, Normant, Emmanuel, Bellon, Steven F, Albrecht, Brian K, Harmange, Jean-Christophe, Trojer, Patrick, Audia, James E, Zhang, Ying, Justin, Neil, Chen, Shuyang, Wilson, Jon R, Gamblin, Steven J

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Identification of a genetic determinant responsible for host specificity in Streptococcus thermophilus bacteriophages von Duplessis, Martin, Moineau, Sylvain

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Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance von Crawford, Terry D., Vartanian, Steffan, Côté, Alexandre, Bellon, Steve, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Zawadzke, Laura, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G., Stokoe, David

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Direct N-Cyclopropylation of Cyclic Amides and Azoles Employing a Cyclopropylbismuth Reagent von Gagnon, Alexandre, St-Onge, Miguel, Little, Kelly, Duplessis, Martin, Barabé, Francis

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Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole sca... von Tremblay, Martin, Bonneau, Pierre, Bousquet, Yves, DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Goudreau, Nathalie, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lemke, Christopher T., Mason, Stephen W., Simoneau, Bruno, Surprenant, Simon, Titolo, Steve, Yoakim, Christiane

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Genomic Organization and Molecular Analysis of Virulent Bacteriophage 2972 Infecting an Exopolysaccharide-Producing Streptococcus thermophilus Strain von Lévesque, Céline, Duplessis, Martin, Labonté, Jessica, Labrie, Steve, Fremaux, Christophe, Tremblay, Denise, Moineau, Sylvain

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Characterization of Streptococcus thermophilus Host Range Phage Mutants von Duplessis, Martin, Lévesque, Céline M, Moineau, Sylvain

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Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains von Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G

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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1 von Taylor, Alexander M., Bailey, Chris, Belmont, Lisa D., Campbell, Robert, Cantone, Nico, Côté, Alexandre, Crawford, Terry D., Cummings, Richard, DeMent, Kevin, Duplessis, Martin, Flynn, Megan, Good, Andrew C., Huang, Hon-Ren, Joshi, Shivangi, Leblanc, Yves, Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Adrianne, Poy, Florence, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Tsui, Vickie, Zawadzke, Laura, Sims, Robert J., Audia, James E., Bellon, Steven F., Magnuson, Steven R., Albrecht, Brian K., Cochran, Andrea G.

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Characterization of the cro-ori Region of the Streptococcus thermophilus Virulent Bacteriophage DT1 von Lamothe, Geneviève, Lévesque, Céline, Bissonnette, Frédéric, Cochu, Armelle, Vadeboncoeur, Christian, Frenette, Michel, Duplessis, Martin, Tremblay, Denise, Moineau, Sylvain

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Palladium-Catalyzed Cross-Coupling Reaction of Tricyclopropylbismuth with Aryl Halides and Triflates von Gagnon, Alexandre, Duplessis, Martin, Alsabeh, Pamela, Barabé, Francis

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Discovery, design, and synthesis of indole-based EZH2 inhibitors von Gehling, Victor S., Vaswani, Rishi G., Nasveschuk, Christopher G., Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C., Campbell, Robert, Lee, Christina, Dakin, Les A., Cook, Andrew S., Gagnon, Alexandre, Harmange, Jean-Christophe, Audia, James E., Cummings, Richard T., Normant, Emmanuel, Trojer, Patrick, Albrecht, Brian K.

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Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite von Beaulieu, Pierre L., Bolger, Gordon, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Stammers, Timothy, Kukolj, George, Duan, Jianmin

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GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subuni... von Wang, Shumei, Tsui, Vickie, Crawford, Terry D, Audia, James E, Burdick, Daniel J, Beresini, Maureen H, Côté, Alexandre, Cummings, Richard, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Jiang, Ying, Joshi, Shivangi, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Taylor, Alexander M, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G

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A Practical Synthesis of Indoles via a Pd-Catalyzed C–N Ring Formation von Vaswani, Rishi G, Albrecht, Brian K, Audia, James E, Côté, Alexandre, Dakin, Les A, Duplessis, Martin, Gehling, Victor S, Harmange, Jean-Christophe, Hewitt, Michael C, Leblanc, Yves, Nasveschuk, Christopher G, Taylor, Alexander M

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Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors von Gehling, Victor S, McGrath, John P, Duplessis, Martin, Khanna, Avinash, Brucelle, Francois, Vaswani, Rishi G, Côté, Alexandre, Stuckey, Jacob, Watson, Venita, Cummings, Richard T, Balasubramanian, Srividya, Iyer, Priyadarshini, Sawant, Priyanka, Good, Andrew C, Albrecht, Brian K, Harmange, Jean-Christophe, Audia, James E, Bellon, Steven F, Trojer, Patrick, Levell, Julian R

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Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity von Beaulieu, Pierre L., Bolger, Gordon, Deon, Dan, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, LaPlante, Steven, Stammers, Timothy, Kukolj, George, Duan, Jianmin

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Identification of ( R )- N -((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1 H -indole-3-carboxamide (CPI-1... von Vaswani, Rishi G., Gehling, Victor S., Dakin, Les A., Cook, Andrew S., Nasveschuk, Christopher G., Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C., Campbell, Robert, Lee, Christina, Cantone, Nico, Cummings, Richard T., Normant, Emmanuel, Bellon, Steven F., Albrecht, Brian K., Harmange, Jean-Christophe, Trojer, Patrick, Audia, James E., Zhang, Ying, Justin, Neil, Chen, Shuyang, Wilson, Jon R., Gamblin, Steven J.

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Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay von Stammers, Timothy A., Coulombe, René, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, Goulet, Sylvie, Jakalian, Araz, LaPlante, Steven, Rancourt, Jean, Thavonekham, Bounkham, Wernic, Dominik, Kukolj, George, Beaulieu, Pierre L.

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Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors von James, Clint A., DeRoy, Patrick, Duplessis, Martin, Edwards, Paul J., Halmos, Teddy, Minville, Joannie, Morency, Louis, Morin, Sébastien, Simoneau, Bruno, Tremblay, Martin, Bethell, Richard, Cordingley, Michael, Duan, Jianmin, Lamorte, Louie, Pelletier, Alex, Rajotte, Daniel, Salois, Patrick, Tremblay, Sonia, Sturino, Claudio F.

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