Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral scler... von Vaca, Gabriela, Martinez‐Gonzalez, Loreto, Fernandez, Ana, Rojas‐Prats, Elisa, Porras, Gracia, Cuevas, Eva P., Gil, Carmen, Martinez, Ana, Martin‐Requero, Ángeles

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TDP-43 Modulation by Tau‑Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy von Nozal, Vanesa, Martínez-González, Loreto, Gomez-Almeria, Marta, Gonzalo-Consuegra, Claudia, Santana, Paula, Chaikuad, Apirat, Pérez-Cuevas, Eva, Knapp, Stefan, Lietha, Daniel, Ramírez, David, Petralla, Sabrina, Monti, Barbara, Gil, Carmen, Martín-Requero, Angeles, Palomo, Valle, de Lago, Eva, Martinez, Ana

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Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis von Cuevas, Eva P., Martinez-Gonzalez, Loreto, Gordillo, Clara, Tosat-Bitrián, Carlota, Pérez de la Lastra, Carmen, Sáenz, Amets, Gil, Carmen, Palomo, Valle, Martin-Requero, Ángeles, Martinez, Ana

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Molecular Alterations in Sporadic and SOD1 -ALS Immortalized Lymphocytes: Towards a Personalized Therapy von Lastres-Becker, Isabel, Porras, Gracia, Arribas-Blázquez, Marina, Maestro, Inés, Borrego-Hernández, Daniel, Boya, Patricia, Cerdán, Sebastián, García-Redondo, Alberto, Martínez, Ana, Martin-Requero, Ángeles

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Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients von Cosín-Tomàs, Marta, Senserrich, Júlia, Arumí-Planas, Marta, Alquézar, Carolina, Pallàs, Mercè, Martín-Requero, Ángeles, Suñol, Cristina, Kaliman, Perla, Sanfeliu, Coral

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Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment von Martínez-González, Loreto, Rodríguez-Cueto, Carmen, Cabezudo, Diego, Bartolomé, Fernando, Andrés-Benito, Pol, Ferrer, Isidro, Gil, Carmen, Martín-Requero, Ángeles, Fernández-Ruiz, Javier, Martínez, Ana, de Lago, Eva

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Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis von Martín-Cámara, Olmo, Arribas, Marina, Wells, Geoffrey, Morales-Tenorio, Marcos, Martín-Requero, Ángeles, Porras, Gracia, Martínez, Ana, Giorgi, Giorgio, López-Alvarado, Pilar, Lastres-Becker, Isabel, Menéndez, J. Carlos

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Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation von Pérez de la Lastra Aranda, Carmen, Tosat-Bitrián, Carlota, Porras, Gracia, Dafinca, Ruxandra, Muñoz-Torrero, Diego, Talbot, Kevin, Martín-Requero, Ángeles, Martínez, Ana, Palomo, Valle

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TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients von Martinez-Gonzalez, Loreto, Cuevas, Eva P., Tosat-Bitrián, Carlota, Nozal, Vanesa, Gil, Carmen, Palomo, Valle, Martín-Requero, Ángeles, Martinez, Ana

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Targeting cyclin D3/CDK6 activity for treatment of Parkinson's disease von Alquézar, Carolina, Barrio, Estíbaliz, Esteras, Noemí, Encarnación, Ana, Bartolomé, Fernando, Molina, José A., Martín‐Requero, Ángeles

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Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer’s Disease Lymphoblast Alterations von Nuñez-Borque, Emilio, González-Naranjo, Pedro, Bartolomé, Fernando, Alquézar, Carolina, Reinares-Sebastián, Alejandro, Pérez, Concepción, Ceballos, Maria L., Páez, Juan A., Campillo, Nuria E., Martín-Requero, Ángeles

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Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)] von Esteras, Noemí, Bartolomé, Fernando, Alquézar, Carolina, Antequera, Desireé, Muñoz, Úrsula, Carro, Eva, Martín-Requero, Ángeles

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Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions von Rodríguez-Periñán, Guiomar, de la Encarnación, Ana, Moreno, Fermín, López de Munain, Adolfo, Martínez, Ana, Martín-Requero, Ángeles, Alquézar, Carolina, Bartolomé, Fernando

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TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer's Disease Patients von Cuevas, Eva P, Rodríguez-Fernández, Alberto, Palomo, Valle, Martínez, Ana, Martín-Requero, Ángeles

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TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis von Palomo, Valle, Tosat-Bitrian, Carlota, Nozal, Vanesa, Nagaraj, Siranjeevi, Martin-Requero, Angeles, Martinez, Ana

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Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates von Bartolome, Fernando, Esteras, Noemi, Martin-Requero, Angeles, Boutoleau-Bretonniere, Claire, Vercelletto, Martine, Gabelle, Audrey, Le Ber, Isabelle, Honda, Tadashi, Dinkova-Kostova, Albena T., Hardy, John, Carro, Eva, Abramov, Andrey Y.

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Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis von Martínez-González, Loreto, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Porras, Gracia, de Lago, Eva, Martín-Requero, Ángeles, Martínez, Ana

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Multitarget drugs as potential therapeutic agents for alzheimer's disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors von González-Naranjo, Pedro, Pérez, Concepción, González-Sánchez, Marina, Gironda-Martínez, Adrián, Ulzurrun, Eugenia, Bartolomé, Fernando, Rubio-Fernández, Marcos, Martin-Requero, Angeles, Campillo, Nuria E., Páez, Juan A.

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Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients von Posa, Diana, Martínez-González, Loreto, Bartolomé, Fernando, Nagaraj, Siranjeevi, Porras, Gracia, Martínez, Ana, Martín-Requero, Ángeles

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Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts von Porras, Gracia, Ruiz, Silvana, Maestro, Inés, Borrego-Hernández, Daniel, Redondo, Alberto G, Martínez, Ana, Martín-Requero, Ángeles

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