Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies von San José-Enériz, Edurne, Agirre, Xabier, Rabal, Obdulia, Vilas-Zornoza, Amaia, Sanchez-Arias, Juan A., Miranda, Estibaliz, Ugarte, Ana, Roa, Sergio, Paiva, Bruno, Estella-Hermoso de Mendoza, Ander, Alvarez, Rosa María, Casares, Noelia, Segura, Victor, Martín-Subero, José I., Ogi, François-Xavier, Soule, Pierre, Santiveri, Clara M., Campos-Olivas, Ramón, Castellano, Giancarlo, de Barrena, Maite Garcia Fernandez, Rodriguez-Madoz, Juan Roberto, García-Barchino, Maria José, Lasarte, Juan Jose, Avila, Matias A, Martinez-Climent, Jose Angel, Oyarzabal, Julen, Prosper, Felipe

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Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia von Klintman, Jenny, Appleby, Niamh, Stamatopoulos, Basile, Ridout, Katie, Eyre, Toby A., Robbe, Pauline, Pascua, Laura Lopez, Knight, Samantha J.L., Dreau, Helene, Cabes, Maite, Popitsch, Niko, Ehinger, Mats, Martín-Subero, Jose I., Campo, Elías, Månsson, Robert, Rossi, Davide, Taylor, Jenny C., Vavoulis, Dimitrios V., Schuh, Anna

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Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia von Kulis, Marta, Heath, Simon, Bibikova, Marina, Queirós, Ana C, Navarro, Alba, Clot, Guillem, Martínez-Trillos, Alejandra, Castellano, Giancarlo, Brun-Heath, Isabelle, Pinyol, Magda, Barberán-Soler, Sergio, Papasaikas, Panagiotis, Jares, Pedro, Beà, Sílvia, Rico, Daniel, Ecker, Simone, Rubio, Miriam, Royo, Romina, Ho, Vincent, Klotzle, Brandy, Hernández, Lluis, Conde, Laura, López-Guerra, Mónica, Colomer, Dolors, Villamor, Neus, Aymerich, Marta, Rozman, María, Bayes, Mónica, Gut, Marta, Gelpí, Josep L, Orozco, Modesto, Fan, Jian-Bing, Quesada, Víctor, Puente, Xose S, Pisano, David G, Valencia, Alfonso, López-Guillermo, Armando, Gut, Ivo, López-Otín, Carlos, Campo, Elías, Martín-Subero, José I

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Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage von Queirós, Ana C., Beekman, Renée, Vilarrasa-Blasi, Roser, Duran-Ferrer, Martí, Clot, Guillem, Merkel, Angelika, Raineri, Emanuele, Russiñol, Nuria, Castellano, Giancarlo, Beà, Sílvia, Navarro, Alba, Kulis, Marta, Verdaguer-Dot, Núria, Jares, Pedro, Enjuanes, Anna, Calasanz, María José, Bergmann, Anke, Vater, Inga, Salaverría, Itziar, van de Werken, Harmen J.G., Wilson, Wyndham H., Datta, Avik, Flicek, Paul, Royo, Romina, Martens, Joost, Giné, Eva, Lopez-Guillermo, Armando, Stunnenberg, Hendrik G., Klapper, Wolfram, Pott, Christiane, Heath, Simon, Gut, Ivo G., Siebert, Reiner, Campo, Elías, Martín-Subero, José I.

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Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia von Papakonstantinou, Nikos, Ntoufa, Stavroula, Tsagiopoulou, Maria, Moysiadis, Theodoros, Bhoi, Sujata, Malousi, Andigoni, Psomopoulos, Fotis, Mansouri, Larry, Laidou, Stamatia, Papazoglou, Despoina, Gounari, Maria, Pasentsis, Konstantinos, Plevova, Karla, Kuci‐Emruli, Venera, Duran‐Ferrer, Marti, Davis, Zadie, Ek, Sara, Rossi, Davide, Gaidano, Gianluca, Ritgen, Matthias, Oscier, David, Stavroyianni, Niki, Pospisilova, Sarka, Davi, Frederic, Ghia, Paolo, Hadzidimitriou, Anastasia, Belessi, Chrysoula, Martin‐Subero, Jose I, Pott, Christiane, Rosenquist, Richard, Stamatopoulos, Kostas

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Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response von Agirre, Xabier, Meydan, Cem, Jiang, Yanwen, Garate, Leire, Doane, Ashley S., Li, Zhuoning, Verma, Akanksha, Paiva, Bruno, Martín-Subero, José I., Elemento, Olivier, Mason, Christopher E., Prosper, Felipe, Melnick, Ari

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MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer von Caramés, Cristina, Cristobal, Ion, Moreno, Víctor, Marín, Juan P, González-Alonso, Paula, Torrejón, Blanca, Minguez, Pablo, Leon, Ana, Martín, José I, Hernández, Roberto, Pedregal, Manuel, Martín, María J, Cortés, Delia, García-Olmo, Damian, Fernández, María J, Rojo, Federico, García-Foncillas, Jesús

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A hierarchical architecture for recognising intentionality in mental tasks on a brain-computer interface von Salazar-Ramirez, Asier, Martin, Jose I, Martinez, Raquel, Arruti, Andoni, Muguerza, Javier, Sierra, Basilio

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Cell-Cycle-Dependent Reconfiguration of the DNA Methylome during Terminal Differentiation of Human B Cells into Plasma Cells von Caron, Gersende, Hussein, Mourad, Kulis, Marta, Delaloy, Céline, Chatonnet, Fabrice, Pignarre, Amandine, Avner, Stéphane, Lemarié, Maud, Mahé, Elise A., Verdaguer-Dot, Núria, Queirós, Ana C., Tarte, Karin, Martín-Subero, José I., Salbert, Gilles, Fest, Thierry

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Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regula... von Martínez-Calle, Nicolás, Pascual, Marien, Ordoñez, Raquel, Enériz, Edurne San José, Kulis, Marta, Miranda, Estíbaliz, Guruceaga, Elisabeth, Segura, Víctor, Larráyoz, María José, Bellosillo, Beatriz, Calasanz, María José, Besses, Carles, Rifón, José, Martín-Subero, José I, Agirre, Xabier, Prosper, Felipe

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CISNE: An accurate description of dose-effect and synergism in combination therapies von García-Fuente, Amador, Vázquez, Fernando, Viéitez, José M., García Alonso, Francisco J., Martín, José I., Ferrer, Jaime

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SEP/COP: An efficient method to find the best partition in hierarchical clustering based on a new cluster validity index von Gurrutxaga, Ibai, Albisua, Iñaki, Arbelaitz, Olatz, Martín, José I., Muguerza, Javier, Pérez, Jesús M., Perona, Iñigo

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Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures von Lee, Seung-Tae, Muench, Marcus O, Fomin, Marina E, Xiao, Jianqiao, Zhou, Mi, de Smith, Adam, Martín-Subero, José I, Heath, Simon, Houseman, E Andres, Roy, Ritu, Wrensch, Margaret, Wiencke, John, Metayer, Catherine, Wiemels, Joseph L

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Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism von Kandaswamy, Radhika, Sava, Georgina P., Speedy, Helen E., Beà, Sílvia, Martín-Subero, José I., Studd, James B., Migliorini, Gabriele, Law, Philip J., Puente, Xose S., Martín-García, David, Salaverria, Itziar, Gutiérrez-Abril, Jesús, López-Otín, Carlos, Catovsky, Daniel, Allan, James M., Campo, Elías, Houlston, Richard S.

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Expression of the transcribed ultraconserved region 70 and the related long non‐coding RNA AC092652.2‐202 has prognostic value in Chronic Lymphocytic Leukaemia von Bomben, Riccardo, Roisman, Alejandro, D'Agaro, Tiziana, Castellano, Giancarlo, Baumann, Tycho, Delgado, Julio, López‐Guillermo, Armando, Zucchetto, Antonella, Dal‐Bo, Michele, Bravin, Vanessa, Slavutsky, Irma, Vlasova, Anna, Guigó, Roderic, Martin‐Subero, Jose I., Chapaprieta, Vicente, Beekman, Renee, Martin‐García, David, Beà, Sílvia, Salaverria, Itziar, Aymerich, Marta, Campo, Elias, Gattei, Valter, Hernández, Luis

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Robust CRISPR‐Cas9 Genetic Editing of Primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Cells von Mateos‐Jaimez, Judith, Mangolini, Maurizio, Vidal, Anna, Kulis, Marta, Colomer, Dolors, Campo, Elias, Ringshausen, Ingo, Martin‐Subero, Jose I., Maiques‐Diaz, Alba

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DNA methylation profiling of hepatosplenic T-cell lymphoma von Bergmann, Anke K, Fataccioli, Virginie, Castellano, Giancarlo, Martin-Garcia, Nadine, Pelletier, Laura, Ammerpohl, Ole, Bergmann, Juri, Bhat, Jaydeep, Pau, Enrique Carrillo-de Santa, Martín-Subero, José I, Moffitt, Andrea B, Valencia, Alfonso, Oberg, Hans-Heinrich, Wesch, Daniela, Jayne, Sandrine, Dyer, Martin J S, Kabelitz, Dieter, Gaulard, Philippe, Siebert, Reiner

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Towards a standard methodology to evaluate internal cluster validity indices von Gurrutxaga, Ibai, Muguerza, Javier, Arbelaitz, Olatz, Pérez, Jesús M., Martín, José I.

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Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies von Nagel, Inga, Szczepanowski, Monika, Martín-Subero, José I., Harder, Lana, Akasaka, Takashi, Ammerpohl, Ole, Callet-Bauchu, Evelyne, Gascoyne, Randy D., Gesk, Stefan, Horsman, Doug, Klapper, Wolfram, Majid, Aneela, Martinez-Climent, José A., Stilgenbauer, Stephan, Tönnies, Holger, Dyer, Martin J.S., Siebert, Reiner

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Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems von Schuyler, Ronald P., Merkel, Angelika, Raineri, Emanuele, Altucci, Lucia, Vellenga, Edo, Martens, Joost H.A., Pourfarzad, Farzin, Kuijpers, Taco W., Burden, Frances, Farrow, Samantha, Downes, Kate, Ouwehand, Willem H., Clarke, Laura, Datta, Avik, Lowy, Ernesto, Flicek, Paul, Frontini, Mattia, Stunnenberg, Hendrik G., Martín-Subero, José I., Gut, Ivo, Heath, Simon

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