Polymorph Characterization of Active Pharmaceutical Ingredients (APIs) Using Low-Frequency Raman Spectroscopy von Larkin, Peter J., Dabros, Marta, Sarsfield, Beth, Chan, Eric, Carriere, James T., Smith, Brian C.

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Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based... von Gong, Hua, Weinstein, David S., Lu, Zhonghui, Duan, James J.-W., Stachura, Sylwia, Haque, Lauren, Karmakar, Ananta, Hemagiri, Hemalatha, Raut, Dhanya Kumar, Gupta, Arun Kumar, Khan, Javed, Camac, Dan, Sack, John S., Pudzianowski, Andrew, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Borowski, Virna, Xie, Jenny H., Sun, Huadong, D'Arienzo, Celia, Dabros, Marta, Galella, Michael A., Wang, Faye, Weigelt, Carolyn A., Zhao, Qihong, Foster, William, Somerville, John E., Salter-Cid, Luisa M., Barrish, Joel C., Carter, Percy H., Dhar, T.G. Murali

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A Supramolecular Approach to Organic Alloys: Cocrystals and Three- and Four-Component Solid Solutions of 1,4-Diazabicyclo[2.2.2]octane and 4-X-Phenols (X=Cl, CH3, Br) von Dabros, Marta, Emery, Paul R., Thalladi, Venkat R.

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Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists von Zheng, Yi, Qin, Ling, Zacarías, Natalia V. Ortiz, de Vries, Henk, Han, Gye Won, Gustavsson, Martin, Dabros, Marta, Zhao, Chunxia, Cherney, Robert J., Carter, Percy, Stamos, Dean, Abagyan, Ruben, Cherezov, Vadim, Stevens, Raymond C., IJzerman, Adriaan P., Heitman, Laura H., Tebben, Andrew, Kufareva, Irina, Handel, Tracy M.

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Biphenyl Acid Derivatives as APJ Receptor Agonists von Su, Shun, Clarke, Adam, Han, Ying, Chao, Hannguang J, Bostwick, Jeffrey, Schumacher, William, Wang, Tao, Yan, Mujing, Hsu, Mei-Yin, Simmons, Eric, Luk, Chiuwa, Xu, Carrie, Dabros, Marta, Galella, Michael, Onorato, Joelle, Gordon, David, Wexler, Ruth, Gargalovic, Peter S, Lawrence, R. Michael

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Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders von Meng, Wei, Brigance, Robert, Mignone, James, Negash, Lidet, Zhao, Guohua, Ahmad, Saleem, Wang, Wei, Moore, Fang, Ye, Xiang-Yang, Sun, Jung-Hui, Mathur, Arvind, Li, Yi-Xin, Azzara, Anthony, Ma, Zhengping, Chu, Ching-Hsuen, Cullen, Mary Jane, Rooney, Suzanne, Harvey, Susan, Kopcho, Lisa, Abell, Lynn, O’Malley, Kevin, Keim, William, Dierks, Elizabeth A., Chang, Shu, Foster, Kimberly A., Harden, David, Dabros, Marta, Goti, Vineet, De Oliveira, Claudia, Krishna, Gopal, Pelleymounter, Mary Ann, Whaley, Jean, Robl, Jeffrey A., Cheng, Dong, Devasthale, Pratik

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Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders von Turdi, Huji, Chao, Hannguang, Hangeland, Jon J, Ahmad, Saleem, Meng, Wei, Brigance, Robert, Zhao, Guohua, Wang, Wei, Moore, Fang, Ye, Xiang-Yang, Mathur, Arvind, Hou, Xiaoping, Kempson, James, Wu, Dauh-Rurng, Li, Yi-Xin, Azzara, Anthony V, Ma, Zhengping, Chu, Ching-Hsuen, Chen, Luping, Cullen, Mary Jane, Rooney, Suzanne, Harvey, Susan, Kopcho, Lisa, Panemangelor, Reshma, Abell, Lynn, O’Malley, Kevin, Keim, William J, Dierks, Elizabeth, Chang, Shu, Foster, Kimberly, Apedo, Atsu, Harden, David, Dabros, Marta, Gao, Qi, Pelleymounter, Mary Ann, Whaley, Jean M, Robl, Jeffrey A, Cheng, Dong, Lawrence, R. Michael, Devasthale, Pratik

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Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ von Myers, Michael C., Bilder, Donna M., Cavallaro, Cullen L., Chao, Hannguang J., Su, Shun, Burford, Neil T., Nayeem, Akbar, Wang, Tao, Yan, Mujing, Langish, Robert A., Dabros, Marta, Li, Yi-Xin, Rose, Anne V., Behnia, Kamelia, Onorato, Joelle M., Gargalovic, Peter S., Wexler, Ruth R., Lawrence, R. Michael

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Insight to the Thermodynamic Stability of Molecular Crystals through Crystallographic Studies of a Multipolymorph System von Ng, Alicia T., Lai, Chiajen, Dabros, Marta, Gao, Qi

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Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists von Shi, Jun, Gu, Zhengxiang, Jurica, Elizabeth Anne, Wu, Ximao, Haque, Lauren E, Williams, Kristin N, Hernandez, Andres S, Hong, Zhenqiu, Gao, Qi, Dabros, Marta, Davulcu, Akin H, Mathur, Arvind, Rampulla, Richard A, Gupta, Arun Kumar, Jayaram, Ramya, Apedo, Atsu, Moore, Douglas B, Liu, Heng, Kunselman, Lori K, Brady, Edward J, Wilkes, Jason J, Zinker, Bradley A, Cai, Hong, Shu, Yue-Zhong, Sun, Qin, Dierks, Elizabeth A, Foster, Kimberly A, Xu, Carrie, Wang, Tao, Panemangalore, Reshma, Cvijic, Mary Ellen, Xie, Chunshan, Cao, Gary G, Zhou, Min, Krupinski, John, Whaley, Jean M, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce Alan

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Identification and Preclinical Pharmacology of ((1R,3S)‑1-Amino-3-((S)‑6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated... von Gilmore, John L, Xiao, Hai-Yun, Dhar, T. G. Murali, Yang, Michael G, Xiao, Zili, Xie, Jenny, Lehman-McKeeman, Lois D, Gong, Lei, Sun, Huadong, Lecureux, Lloyd, Chen, Cliff, Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L, Zhou, Xia D, Heimrich, Elizabeth M, Thomas, Rochelle, McIntyre, Kim W, Borowski, Virna, Warrack, Bethanne M, Li, Yuwen, Shi, Hong, Levesque, Paul C, Yang, Zheng, Marino, Anthony M, Cornelius, Georgia, D’Arienzo, Celia J, Mathur, Arvind, Rampulla, Richard, Gupta, Anuradha, Pragalathan, Bala, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa M, Carter, Percy H, Dyckman, Alaric J

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Evolution of a Scale-Up Synthesis to a Potent GluN2B Inhibitor and Its Prodrug von Kempson, James, Zhang, Huiping, Wong, Michael K. Y, Li, Jianqing, Li, Peng, Wu, Dauh-Rurng, Rampulla, Richard, Galella, Michael A, Dabros, Marta, Traeger, Sarah C, Muthalagu, Vetrichelvan, Gupta, Anuradha, Arunachalam, Pirama Nayagam, Mathur, Arvind

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A Supramolecular Approach to Organic Alloys: Cocrystals and Three- and Four-Component Solid Solutions of 1,4-Diazabicyclo[2.2.2]octane and 4-X-Phenols (X=Cl, CH3, Br) von Dabros, Marta, Emery, Paul R., Thalladi, Venkat R.

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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672 von Yang, Michael G, Xiao, Zili, Cherney, Robert J, Tebben, Andrew J, Batt, Douglas G, Brown, Gregory D, Chen, Jing, Cvijic, Mary Ellen, Dabros, Marta, Duncia, John V, Galella, Michael, Gardner, Daniel S, Khandelwal, Purnima, Ko, Soo S, Malley, Mary F, Mo, Ruowei, Pang, Jian, Rose, Anne V, Santella, Joseph B, Shi, Hong, Srivastava, Anurag, Traeger, Sarah C, Wang, Bei, Xu, Songmei, Zhao, Rulin, Barrish, Joel C, Mandlekar, Sandhya, Zhao, Qihong, Carter, Percy H

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Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials von Dhar, T. G. Murali, Xiao, Hai-Yun, Xie, Jenny, Lehman-McKeeman, Lois D, Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L, Zhou, Xia D, Heimrich, Elizabeth M, Thomas, Rochelle, McIntyre, Kim W, Warrack, Bethanne, Shi, Hong, Levesque, Paul C, Zhu, Jia L, Hennan, James, Balimane, Praveen, Yang, Zheng, Marino, Anthony M, Cornelius, Georgia, D’Arienzo, Celia J, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Barrish, Joel C, Carter, Percy H, Dyckman, Alaric J

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Effect of alkyl chain parity on the face-selective crystal growth of a drug polymorph von Dabros, Marta, Thalladi, Venkat R

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Crystal Engineering with ⋮C−H···N and C−H···N Hydrogen Bonds von Thalladi, Venkat R, Dabros, Marta, Gehrke, Annette, Weiss, Hans-Christoph, Boese, Roland

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Cover Picture: A Supramolecular Approach to Organic Alloys: Cocrystals and Three- and Four-Component Solid Solutions of 1,4-Diazabicyclo[2.2.2]octane and 4-X-Phenols (X=Cl, CH3, Br... von Dabros, Marta, Emery, Paul R., Thalladi, Venkat R.

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Identification of potent tricyclic prodrug S1P1 receptor modulatorsThe authors declare no competing interests.Electronic supplementary information (ESI) available: Biology and chem... von Marcoux, David, Xiao, Hai-Yun, Murali Dhar, T. G, Xie, Jenny, Lehman-McKeeman, Lois D, Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L, Zhou, Xia D, Heimrich, Elizabeth M, Thomas, Rochelle, McIntyre, Kim W, Shi, Hong, Levesque, Paul C, Sun, Huadong, Yang, Zheng, Marino, Anthony M, Cornelius, Georgia, D'Arienzo, Celia J, Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J, Carter, Percy H, Dyckman, Alaric J

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Identification of potent tricyclic prodrug S1P1 receptor modulators von Marcoux, David, Xiao, Hai-Yun, Murali Dhar, TG, Xie, Jenny, Lehman-McKeeman, Lois D, Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L, Zhou, Xia D, Heimrich, Elizabeth M, Thomas, Rochelle, McIntyre, Kim W, Shi, Hong, Levesque, Paul C, Sun, Huadong, Yang, Zheng, Marino, Anthony M, Cornelius, Georgia, D'Arienzo, Celia J, Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J, Carter, Percy H, Dyckman, Alaric J

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