Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary von Moran, Sebastián, Martinez-Cardús, Anna, Boussios, Stergios, Esteller, Manel

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Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR von Vizoso, Miguel, Ferreira, Humberto J, Lopez-Serra, Paula, Carmona, F Javier, Martínez-Cardús, Anna, Girotti, Maria Romina, Villanueva, Alberto, Guil, Sonia, Moutinho, Catia, Liz, Julia, Portela, Anna, Heyn, Holger, Moran, Sebastian, Vidal, August, Martinez-Iniesta, Maria, Manzano, Jose L, Fernandez-Figueras, Maria Teresa, Elez, Elena, Muñoz-Couselo, Eva, Botella-Estrada, Rafael, Berrocal, Alfonso, Pontén, Fredrik, Oord, Joost van den, Gallagher, William M, Frederick, Dennie T, Flaherty, Keith T, McDermott, Ultan, Lorigan, Paul, Marais, Richard, Esteller, Manel

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Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer von Codony-Servat, Jordi, Cuatrecasas, Miriam, Asensio, Elena, Montironi, Carla, Martínez-Cardús, Anna, Marín-Aguilera, Mercedes, Horndler, Carlos, Martínez-Balibrea, Eva, Rubini, Michele, Jares, Pedro, Reig, Oscar, Victoria, Iván, Gaba, Lydia, Martín-Richard, Marta, Alonso, Vicente, Escudero, Pilar, Fernández-Martos, Carlos, Feliu, Jaime, Méndez, Jose Carlos, Méndez, Miguel, Gallego, Javier, Salud, Antonieta, Rojo, Federico, Castells, Antoni, Prat, Aleix, Rosell, Rafael, García-Albéniz, Xabier, Camps, Jordi, Maurel, Joan

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Deciphering the impact of STAT3 activation mediated by PTPRT promoter hypermethylation as biomarker of response to paclitaxel-plus-cetuximab in patients with recurrent or metastati... von Cirauqui, Beatriz Cirauqui, Peguera, Adrià Bernat, Pi-Sunyer, Ariadna Quer, Ferrando-Díez, Angelica, Serrano, Jose Luis Ramírez, Viñolas, Marta Domenech, García, Iris Teruel, García, Vanesa Quiroga, Oukadour, Imane Chaib, Valencia, Andrea González, Vergara, Pilar Hernández, de Aguirre Egaña, Itziar, Herrero, Cristina Queralt, Carbonell, Oscar Mesía, Paradís, Assumpció López, Esteve, Anna, Vila, Mireia Margelí, Rosell, Rafael, Martínez-Cardús, Anna, Mesía, Ricard

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KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer von Simó-Riudalbas, Laia, Pérez-Salvia, Montserrat, Setien, Fernando, Villanueva, Alberto, Moutinho, Catia, Martínez-Cardús, Anna, Moran, Sebastian, Berdasco, Maria, Gomez, Antonio, Vidal, Enrique, Soler, Marta, Heyn, Holger, Vaquero, Alejandro, de la Torre, Carolina, Barceló-Batllori, Silvia, Vidal, August, Roz, Luca, Pastorino, Ugo, Szakszon, Katalin, Borck, Guntram, Moura, Conceição S, Carneiro, Fátima, Zondervan, Ilse, Savola, Suvi, Iwakawa, Reika, Kohno, Takashi, Yokota, Jun, Esteller, Manel

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A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect von Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Leal, Lucía, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Ørntoft, Torben F., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Heiden, Matthew G. Vander, Albar, Juan Pablo, Esteller, Manel

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Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma von Wouters, Jasper, Vizoso, Miguel, Martinez-Cardus, Anna, Carmona, F Javier, Govaere, Olivier, Laguna, Teresa, Joseph, Jesuchristopher, Dynoodt, Peter, Aura, Claudia, Foth, Mona, Cloots, Roy, van den Hurk, Karin, Balint, Balazs, Murphy, Ian G, McDermott, Enda W, Sheahan, Kieran, Jirström, Karin, Nodin, Bjorn, Mallya-Udupi, Girish, van den Oord, Joost J, Gallagher, William M, Esteller, Manel

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Increased levels of copper efflux transporter ATP7B are associated with poor outcome in colorectal cancer patients receiving oxaliplatin‐based chemotherapy von Martinez‐Balibrea, Eva, Martínez‐Cardús, Anna, Musulén, Eva, Ginés, Alba, Manzano, José Luis, Aranda, Enrique, Plasencia, Carmen, Neamati, Nouri, Abad, Albert

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Targeted therapy or immunotherapy in BRAF-mutated metastatic melanoma: a Spanish center's decade of experience von Sun, Chen, España, Sofia, Richarz, Nina, Solé-Blanch, Carme, Boada, Aram, Martinez-Cardús, Anna, Chu, Alan, Liu, Zongwen, Manzano, Jose Luis

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Validation of DNA methylation profiling in formalin-fixed paraffin-embedded samples using the Infinium HumanMethylation450 Microarray von Moran, Sebastián, Vizoso, Miguel, Martinez-Cardús, Anna, Gomez, Antonio, Matías-Guiu, Xavier, Chiavenna, Sebastián M, Fernandez, Andrés G, Esteller, Manel

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Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance von Martinez-Balibrea, Eva, Martínez-Cardús, Anna, Ginés, Alba, Ruiz de Porras, Vicenç, Moutinho, Catia, Layos, Laura, Manzano, José Luis, Bugés, Cristina, Bystrup, Sara, Esteller, Manel, Abad, Albert

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A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines von Eva Martinez-Balibrea, Carmen Plasencia, Alba Ginés, Anna Martinez-Cardús, Eva Musulén, Rodrigo Aguilera, José Luis Manzano, Nouri Neamati, Albert Abad

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Resistant mechanisms to BRAF inhibitors in melanoma von Manzano, José Luís, Layos, Laura, Bugés, Cristina, de Los Llanos Gil, María, Vila, Laia, Martínez-Balibrea, Eva, Martínez-Cardús, Anna

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The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition von Oliveira-Mateos, Cristina, Sánchez-Castillo, Anaís, Soler, Marta, Obiols-Guardia, Aida, Piñeyro, David, Boque-Sastre, Raquel, Calleja-Cervantes, Maria E., Castro de Moura, Manuel, Martínez-Cardús, Anna, Rubio, Teresa, Pelletier, Joffrey, Martínez-Iniesta, Maria, Herrero-Martín, David, Tirado, Oscar M., Gentilella, Antonio, Villanueva, Alberto, Esteller, Manel, Farré, Lourdes, Guil, Sonia

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Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer von Martínez-Cardús, Anna, Moran, Sebastian, Musulen, Eva, Moutinho, Cátia, Manzano, Jose L, Martinez-Balibrea, Eva, Tierno, Montserrat, Élez, Elena, Landolfi, Stefania, Lorden, Patricia, Arribas, Carles, Müller, Fabian, Bock, Christoph, Tabernero, Josep, Esteller, Manel

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Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs von Nogales, Vanesa, Reinhold, William C, Varma, Sudhir, Martinez-Cardus, Anna, Moutinho, Catia, Moran, Sebastian, Heyn, Holger, Sebio, Ana, Barnadas, Agusti, Pommier, Yves, Esteller, Manel

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Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer von Kel, Alexander, Boyarskikh, Ulyana, Stegmaier, Philip, Leskov, Leonid S, Sokolov, Andrey V, Yevshin, Ivan, Mandrik, Nikita, Stelmashenko, Daria, Koschmann, Jeannette, Kel-Margoulis, Olga, Krull, Mathias, Martínez-Cardús, Anna, Moran, Sebastian, Esteller, Manel, Kolpakov, Fedor, Filipenko, Maxim, Wingender, Edgar

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Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer von MOUTINHO, Catia, MARTINEZ-CARDUS, Anna, ELEZ, Elena, TABERNERO, Josep, SALAZAR, Ramon, ABAD, Albert, ESTELLER, Manel, SANTOS, Cristina, NAVARRO-PEREZ, Valentin, MARTINEZ-BALIBREA, Eva, MUSULEN, Eva, CARMONA, F. Javier, SARTORE-BIANCHI, Andrea, CASSINGENA, Andrea, SIENA, Salvatore

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Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas von Capdevila, Jaume, Arques, Oriol, Hernandez Mora, Jose Ramon, Matito, Judit, Caratu, Ginevra, Mancuso, Francesco M., Landolfi, Stefania, Barriuso, Jorge, Jimenez-Fonseca, Paula, Lopez Lopez, Carlos, Garcia-Carbonero, Rocio, Hernando, Jorge, Matos, Ignacio, Paolo, Nuciforo, Hernandez-Losa, Javier, Esteller, Manel, Martinez-Cardus, Anna, Tabernero, Josep, Vivancos, Ana, Palmer, Hector G.

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Biological and clinical perspectives of the actionable gene fusions and amplifications involving tyrosine kinase receptors in lung cancer von Saigí, Maria, Carcereny, Enric, Morán, Teresa, Cucurull, Marc, Domènech, Marta, Hernandez, Ainhoa, Martinez-Cardús, Anna, Pros, Eva, Sanchez-Cespedes, Montse

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