The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression von Garcia-Ortiz, Almudena, Rodriguez-Garcia, Yaiza, Encinas, Jessica, Maroto-Martin, Elena, Castellano, Eva, Teixido, Joaquin, Martinez-Lopez, Joaquin

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S256: HLA‐E/NKG2A CHECKPOINT DRIVES MULTIPLE MYELOMA RESISTANCE TO CAR‐NK THERAPY von Encinas, Jessica, García‐Ortiz, Almudena, Maroto‐Martín, Elena, Castellano, Eva, Oliva, Raquel, Alonso Fernández, Rafael, Teresa Cedena Romero, Maria, Leivas, Alejandra, Martín‐Antonio, Beatriz, Suñe, Guillermo, Lee, Dean A., Powell, Daniel J., Río, Paula, Martinez‐Lopez, Joaquín, Valeri, Antonio

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Overcoming tumor resistance mechanisms in CAR-NK cell therapy von Valeri, Antonio, García-Ortiz, Almudena, Castellano, Eva, Córdoba, Laura, Maroto-Martín, Elena, Encinas, Jessica, Leivas, Alejandra, Río, Paula, Martínez-López, Joaquín

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OA-02 α-NKG2A blockade overcomes multiple myeloma resistance to BCMA and NKG2D CAR-NKAE cells von Encinas, Jessica, García-Ortiz, Almudena, Maroto-Martín, Elena, Castellano, Eva, Oliva, Raquel, Alonso, Rafael, Cedena, Teresa, Leivas, Alejandra, García, Laura García, Martín-Antonio, Beatriz, Suñe, Guillermo, Lee, Dean, Prabhala, Rao, Jr, Daniel Powell, Río, Paula, Martinez-Lopez, Joaquín, Valeri, Antonio

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OA-32 p300 Catalytic Inhibition Selectively Disrupts IRF4 Oncogenic Programs Impacting Multiple Myeloma Cell Growth and Survival von McKeown, Michael R., Giorgetti, Giulia, Lenoir, Walter F., Kobylarz, Marek, Hopkins, Tamara, Glore, Wayne, Shum, Michelle G., Martín, Elena Maroto, Wen, Kenneth, Farrukh, Hizra, Mori, Kameron R., Gao, Hua, Carvajal, Luis A., Obholzer, Nikolaus, Trotter, Benjamin, Dinsmore, Christopher, Munshi, Nikhil, Rahl, Peter, Lin, Charles, Fulciniti, Mariateresa

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P-015: Comprehensive comparison of allogenic CAR NK cells for MM treatment von Martín, Elena Maroto, Encinas, Jessica, García-Ortiz, Almudena, Castellano, Eva, Ugalde, Laura, Alonso, Rafael, Leivas, Alejandra, Paciello, Mari Liz, Garrido, Vanesa, Martín-Antonio, Beatriz, Suñe, Guillermo, Cedena, Maria-Teresa, Jr, Daniel J Powell, Río, Paula, López, Joaquín Martinez, Valeri, Antonio

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P-007: Exploring a safety switch in NKG2D and BCMA CAR NK-92MI immunotherapy von Martín, Elena Maroto, Encinas, Jessica, García-Ortiz, Almudena, Castellano, Eva, Ugalde, Laura, Alonso, Rafael, Leivas, Alejandra, Paciello, Mari Liz, Garrido, Vanesa, Martín-Antonio, Beatriz, Suñe, Guillermo, Cedena, Teresa, Powell, Daniel J., Río, Paula, Martínez-López, Joaquín, Valeri, Antonio

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Exploring NKG2D and BCMA-CAR NK-92 for Adoptive Cellular Therapy to Multiple Myeloma von Martín, Elena Maroto, Encinas, Jessica, García-Ortiz, Almudena, Ugalde, Laura, Fernández, Rafael Alonso, Leivas, Alejandra, Paciello, María Liz, Garrido, Vanesa, Martín-Antonio, Beatriz, Suñe, Guillermo, Cedena, Maria-Teresa, Powell, Daniel J., Río, Paula, Martinez-Lopez, Joaquin, Valeri, Antonio

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Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD+ Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies von Giorgetti, Giulia, Becherini, Pamela, Maroto-Martin, Elena, Fenoglio, Daniela, Soncini, Debora, Martinuzzi, Claudia, Bruzzone, Santina, Benzi, Andrea, Nahimana, Aimable, Uras, Chiara Rosa Maria, Schavgoulidze, Anaïs, Ng Fong, Jessica, Lemoli, Roberto M., Munshi, Nikhil C, Fulciniti, Mariateresa, Cea, Michele

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OA-02 Multiplex CRISPR/Cas9 Genome Editing of Cord Blood-derived CAR NK Cells to Improve Their Persistence and Antitumoral Potential Against Multiple Myeloma von Castellano, Eva, García-Ortiz, Almudena, Ugalde, Laura, Maroto-Martin, Elena, Encinas, Jessica, Oliva, Raquel, García-García, Laura, Álvarez, Noemí, Carreño, Gonzalo, Ayala, Rosa, Córdoba, Laura, Leivas, Alejandra, Suñé, Guillermo, Fernández, Rafael Alonso, Cedena, Maria Teresa, Martín-Antonio, Beatriz, Martínez-Lopez, Joaquín, Río, Paula, Valeri, Antonio

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Venetoclax resistance leads to broad resistance to standard-of-care anti-MM agents, but not to immunotherapies von Deng, Shuhui, Derebail, Sanika, Weiler, Vera Joy, Fong Ng, Jessica, Maroto-Martin, Elena, Chatterjee, Madhumouli, Giorgetti, Giulia, Chakraborty, Chandraditya, Kalhotra, Poonam, Du, Ting, Yao, Yao, Prabhala, Rao, Shammas, Masood, Gulla, Annamaria, Aktas Samur, Anil, Samur, Mehmet Kemal, Qiu, Lugui, Anderson, Kenneth C., Fulciniti, Mariateresa, Munshi, Nikhil C.

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PATIENT-DERIVED FULLY-HUMANIZED MOUSE AND METHOD FOR PREDICTING THE RESPONSE TO MULTIPLE MYELOMA TREATMENTS USING THE SAME von GARCÍA ORTIZ, Almudena, RÍO, Paula, CASTELLANO ESPARZA, Eva, ALONSO FERNÁNDEZ, Rafael, MAROTO MARTÍN, Elena, ENCINAS MAYORAL, Jessica, MARTÍNEZ LÓPEZ, Joaquin, VALERI, Antonio

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PATIENT-DERIVED FULLY-HUMANIZED MOUSE AND METHOD FOR PREDICTING THE RESPONSE TO MULTIPLE MYELOMA TREATMENTS USING THE SAME von Maroto Martín, Elena, Valeri Lozano, Antonio, Castellano Esparza, Eva, Alonso Fernández, Rafael, Río Galdo, Paula, Martínez López, Joaquín, García Ortiz, Almudena, Encinas Mayoral, Jessica

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COMBINATION OF CAR-NK CELLS WITH NKG2A BLOCKING AGENTS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND USE THEREOF von GARCÍA ORTIZ, Almudena, CASTELLANO ESPARZA, Eva, GALLARDO DELGADO, Miguel, MARTÍNEZ LÓPEZ, Joaquín, VALERI LOZANO, Antonio, ENCINAS MAYORAL, Jessica, MAROTO MARTÍN, Elena

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COMBINATION OF CAR-NK CELLS WITH NKG2A BLOCKING AGENTS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND USE THEREOF von Maroto Martín, Elena, Valeri Lozano, Antonio, Gallardo Delgado, Miguel, Castellano Esparza, Eva, Martínez López, Joaquín, García Ortiz, Almudena, Encinas Mayoral, Jessica

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The care of non-institutionalized ADL-dependent people in the Orcasitas neighborhood of Madrid (Spain) during the Covid-19 pandemic and its relationship with social inequalities, i... von Martín Moreno, Vicente, Martínez Sanz, María Inmaculada, Martín Fernández, Amanda, Sánchez Rodríguez, Elena, Sánchez González, Irene, Herranz Hernando, Julia, Fernández Gallardo, Miriam, Recuero Vázquez, Miguel, Benítez Calderón, María Palma, Sevillano Fuentes, Eva, Pérez Rico, Elena, Calderón Jiménez, Laura, Guerra Maroto, Sara, Alonso Samperiz, Helena, León Saiz, Irene

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The influence of nationwide COVID-19 lockdown on the functional impairment and long-term survival of dependent people for carrying out basic activities of daily living in a neighbo... von Martín Moreno, Vicente, Martínez Sanz, María Inmaculada, Fernández Gallardo, Miriam, Martín Fernández, Amanda, Benítez Calderón, María Palma, Alonso Samperiz, Helena, Pérez Rico, Elena, Calderón Jiménez, Laura, Guerra Maroto, Sara, Sánchez Rodríguez, Elena, Sevillano Fuentes, Eva, Sánchez González, Irene, Recuero Vázquez, Miguel, Herranz Hernando, Julia, León Saiz, Irene

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Influence of geographical location, site and silvicultural parameters, on volatile composition of Quercus pyrenaica Willd. wood used in wine aging von Alanon, MElena, Perez-Coello, MSoledad, Diaz-Maroto, Ignacio J, Martin-Alvarez, Pedro J, Vila-Lameiro, Pablo, Diaz-Maroto, MConsuelo

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Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain von Puig-Asensio, M., Padilla, B., Garnacho-Montero, J., Zaragoza, O., Aguado, J.M., Zaragoza, R., Montejo, M., Muñoz, P., Ruiz-Camps, I., Cuenca-Estrella, M., Almirante, B.

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Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial von Smith, Matthew R, Scher, Howard I, Sandhu, Shahneen, Efstathiou, Eleni, Lara, Primo N, Yu, Evan Y, Chi, Kim N, Ståhl, Olof, Olmos, David, Danila, Daniel C, Espina, Byron M, Zhao, Xin, Urtishak, Karen A, Francis, Peter, Lopez-Gitlitz, Angela, Parnis, Francis, Horvath, Lisa G., Steer, Christopher, Marx, Gavin, Sandhu, Shahneen, Ferguson, Thomas, Luyten, Daisy, Lumen, Nicolaas, Dirix, Luc, Goeminne, Jean-Charles, Gil, Thierry, Vulsteke, Christof, Kussumoto, Celio, Franke, Fabio A., Martinelli de Oliveira, Fabricio Augusto, Pereira de Santana Gomes, Andrea Juliana, Preto, Daniel D'Almeida, Zucca, Luis Eduardo, Borges, Giuliano Santos, Murad, Andre M., Saad, Fred, Chi, Kim N., Fradet, Yves, Fleshner, Neil E., Emmenegger, Urban, Brasso, Klaus, Culine, Stephane, Thiery-Vuillemin, Antoine, Joly, Florence, Fléchon, Aude, Hilgers, Werner, Borchiellini, Delphine, Barthélémy, Philippe, Berger, Raanan, Mermershtain, Wilmosh, Peer, Avivit, Sella, Avishay, Voortman, Johannes, Aarts, Maureen J., Gietema, Jourik A., Choi, Young-Deuk, Gafanov, Rustem A., Kopyltsov, Evgeniy, Carles, Joan, Mellado, Begoña, Maroto, José Pablo, García-Donás, Jesús, Rodríguez Moreno, Juan Francisco, Durán, Ignacio, Pérez-Valderrama, Begoña, Castro, Elena, Olmos, David, Méndez-Vidal, María José, Muñoz-Langa, José, Herranz, Urbano Anido, Puente Vázquez, Javier, Castellanos, Enrique, Hellström, Martin, Widmark, Anders, Lissbrant, Ingela Franck, Jellvert, Åsa, Külich, Cecilia, Blom, René, Kang, Chih-Hsiung, Ou, Yen-Chuan, Wang, Shian-Shiang, Attard, Gerhardt, Bahl, Amit, Kellati, Prasad, Parikh, Omi, Srinivasan, Rajaguru, Lester, Jason F., Staffurth, John N., Cheng, Heather H., Efstathiou, Eleni, Pilié, Patrick G., George, Daniel J., Karsh, Lawrence I., Kelly, W. Kevin, Danila, Daniel C., Smith, Matthew R., Heath, Elisabeth I., Vaishampayan, Ulka N., Emamekhoo, Hamid, Pinski, Jacek K.

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