Abstract 12593: Type 2 Diabetes Mellitus Polygenic Score Predicts New Onset Diabetes in Patients With Established Atherosclerotic Cardiovascular Disease: A FOURIER Sub-Study von Moura, Filipe A, Kamanu, Frederick, Wiviott, Stephen D, Giugliano, Robert, Florez, Jose C, Roselli, Carolina, Keech, Anthony C, Lubitz, Steven A, Ellinor, Patrick T, Ruff, Christian T, Marston, Nicholas F, Sabatine, Marc S

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Abstract 12228: Development of a Novel Polygenic Risk Score to Predict Risk of Aortic Stenosis Events von Small, Aeron M, Melloni, Giorgio, Kamanu, Frederick, Roselli, Carolina, Bergmark, Brian A, Bonaca, Marc P, Odonoghue, Michelle L, Giugliano, Robert, Scirica, Benjamin M, Bhatt, Deepak L, Antman, Elliott M, Raz, Itamar, Peloso, Gina, WILSON, PETER, Odonnell, Christopher J, Natarajan, Pradeep, Braunwald, Eugene, Lubitz, Steven A, Ellinor, Patrick T, Ruff, Christian T, Sabatine, Marc S, Marston, Nicholas F

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Ribosomal profiling of human endogenous retroviruses in healthy tissues von Dopkins, Nicholas, Singh, Bhavya, Michael, Stephanie, Zhang, Panpan, Marston, Jez L, Fei, Tongyi, Singh, Manvendra, Feschotte, Cedric, Collins, Nicholas, Bendall, Matthew L, Nixon, Douglas F

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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants von Aragam, Krishna G., Jiang, Tao, Goel, Anuj, Kanoni, Stavroula, Wolford, Brooke N., Atri, Deepak S., Weeks, Elle M., Wang, Minxian, Hindy, George, Zhou, Wei, Grace, Christopher, Roselli, Carolina, Marston, Nicholas A., Kamanu, Frederick K., Surakka, Ida, Venegas, Loreto Muñoz, Sherliker, Paul, Koyama, Satoshi, Ishigaki, Kazuyoshi, Åsvold, Bjørn O., Brown, Michael R., Brumpton, Ben, de Vries, Paul S., Giannakopoulou, Olga, Giardoglou, Panagiota, Gudbjartsson, Daniel F., Güldener, Ulrich, Haider, Syed M. Ijlal, Helgadottir, Anna, Ibrahim, Maysson, Kastrati, Adnan, Kessler, Thorsten, Kyriakou, Theodosios, Konopka, Tomasz, Li, Ling, Ma, Lijiang, Meitinger, Thomas, Mucha, Sören, Munz, Matthias, Murgia, Federico, Nielsen, Jonas B., Nöthen, Markus M., Pang, Shichao, Reinberger, Tobias, Schnitzler, Gavin, Smedley, Damian, Thorleifsson, Gudmar, von Scheidt, Moritz, Ulirsch, Jacob C., Arnar, David O., Burtt, Noël P., Costanzo, Maria C., Flannick, Jason, Ito, Kaoru, Jang, Dong-Keun, Kamatani, Yoichiro, Khera, Amit V., Komuro, Issei, Kullo, Iftikhar J., Lotta, Luca A., Nelson, Christopher P., Roberts, Robert, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Webb, Thomas R., Baras, Aris, Björkegren, Johan L. M., Boerwinkle, Eric, Dedoussis, George, Holm, Hilma, Hveem, Kristian, Melander, Olle, Morrison, Alanna C., Orho-Melander, Marju, Rallidis, Loukianos S., Ruusalepp, Arno, Sabatine, Marc S., Stefansson, Kari, Zalloua, Pierre, Ellinor, Patrick T., Farrall, Martin, Danesh, John, Ruff, Christian T., Finucane, Hilary K., Hopewell, Jemma C., Clarke, Robert, Gupta, Rajat M., Erdmann, Jeanette, Samani, Nilesh J., Schunkert, Heribert, Watkins, Hugh, Willer, Cristen J., Deloukas, Panos, Kathiresan, Sekar, Butterworth, Adam S.

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Effect of Vupanorsen on Non–High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70 von Bergmark, Brian A., Marston, Nicholas A., Bramson, Candace R., Curto, Madelyn, Ramos, Vesper, Jevne, Alexandra, Kuder, Julia F., Park, Jeong-Gun, Murphy, Sabina A., Verma, Subodh, Wojakowski, Wojtek, Terra, Steven G., Sabatine, Marc S., Wiviott, Stephen D.

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Engineered immunogens to elicit antibodies against conserved coronavirus epitopes von Kapingidza, A. Brenda, Marston, Daniel J., Harris, Caitlin, Wrapp, Daniel, Winters, Kaitlyn, Mielke, Dieter, Xiaozhi, Lu, Yin, Qi, Foulger, Andrew, Parks, Rob, Barr, Maggie, Newman, Amanda, Schäfer, Alexandra, Eaton, Amanda, Flores, Justine Mae, Harner, Austin, Catanzaro, Nicholas J., Mallory, Michael L., Mattocks, Melissa D., Beverly, Christopher, Rhodes, Brianna, Mansouri, Katayoun, Van Itallie, Elizabeth, Vure, Pranay, Dunn, Brooke, Keyes, Taylor, Stanfield-Oakley, Sherry, Woods, Christopher W., Petzold, Elizabeth A., Walter, Emmanuel B., Wiehe, Kevin, Edwards, Robert J., Montefiori, David C., Ferrari, Guido, Baric, Ralph, Cain, Derek W., Saunders, Kevin O., Haynes, Barton F., Azoitei, Mihai L.

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Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes von Halford, Jennifer L., Morrill, Valerie N., Choi, Seung Hoan, Jurgens, Sean J., Melloni, Giorgio, Marston, Nicholas A., Weng, Lu-Chen, Nauffal, Victor, Hall, Amelia W., Gunn, Sophia, Austin-Tse, Christina A., Pirruccello, James P., Khurshid, Shaan, Rehm, Heidi L., Benjamin, Emelia J., Boerwinkle, Eric, Brody, Jennifer A., Correa, Adolfo, Fornwalt, Brandon K., Gupta, Namrata, Haggerty, Christopher M., Harris, Stephanie, Heckbert, Susan R., Hong, Charles C., Kooperberg, Charles, Lin, Henry J., Loos, Ruth J. F., Mitchell, Braxton D., Morrison, Alanna C., Post, Wendy, Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Rotter, Jerome I., Schnatz, Peter F., Soliman, Elsayed Z., Sotoodehnia, Nona, Wong, Eugene K., Sabatine, Marc S., Ruff, Christian T., Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.

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Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes von Halford, Jennifer L., Morrill, Valerie N., Choi, Seung Hoan, Jurgens, Sean J., Melloni, Giorgio, Marston, Nicholas A., Weng, Lu-Chen, Nauffal, Victor, Hall, Amelia W., Gunn, Sophia, Austin-Tse, Christina A., Pirruccello, James P., Khurshid, Shaan, Rehm, Heidi L., Benjamin, Emelia J., Boerwinkle, Eric, Brody, Jennifer A., Correa, Adolfo, Fornwalt, Brandon K., Gupta, Namrata, Haggerty, Christopher M., Harris, Stephanie, Heckbert, Susan R., Hong, Charles C., Kooperberg, Charles, Lin, Henry J., Loos, Ruth J. F., Mitchell, Braxton D., Morrison, Alanna C., Post, Wendy, Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Rotter, Jerome I., Schnatz, Peter F., Soliman, Elsayed Z., Sotoodehnia, Nona, Wong, Eugene K., Sabatine, Marc S., Ruff, Christian T., Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.

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Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation von Dopkins, Nicholas, Singh, Bhavya, Michael, Stephanie, O'Mara, Morgan M, Marston, Jez L, Fei, Tongyi, Bendall, Matthew L, Nixon, Douglas F

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Reductions in remnant cholesterol and VLDL cholesterol through inhibition of ANGPTL3 protein synthesis: an analysis from the TRANSLATE-TIMI 70 trial von Zimerman, Andre, Wiviott, Stephen D, Park, Jeong-Gun, Murphy, Sabina A, Ran, Xinhui, Bramson, Candace R, Curto, Madelyn, Ramos, Vesper, Jevne, Alexandra, Kuder, Julia F, Verma, Subodh, Wojakowski, Wojtek, Terra, Steven G, Sabatine, Marc S, Bergmark, Brian A, Marston, Nicholas A

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Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients With Cardiometabolic Disease von Marston, Nicholas A., Patel, Parth N., Kamanu, Frederick K., Nordio, Francesco, Melloni, Giorgio M., Roselli, Carolina, Gurmu, Yared, Weng, Lu-Chen, Bonaca, Marc P., Giugliano, Robert P., Scirica, Benjamin M., O’Donoghue, Michelle L., Cannon, Christopher P., Anderson, Christopher D., Bhatt, Deepak L., Gabriel Steg, Philippe, Cohen, Marc, Storey, Robert F., Sever, Peter, Keech, Anthony C., Raz, Itamar, Mosenzon, Ofri, Antman, Elliott M., Braunwald, Eugene, Ellinor, Patrick T., Lubitz, Steven A., Sabatine, Marc S., Ruff, Christian T.

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Stroke genetics informs drug discovery and risk prediction across ancestries von Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, He, Yunye, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Parodi, Livia, Bae, Hee-Joon, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Amouyel, Philippe, Bakker, Mark K., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Cid, Rafael, Ferreira, Leslie E., He, Jing, Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Konuma, Takahiro, Kumar, Amit, Launer, Lenore J., Lee, Keon-Joo, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Meitinger, Thomas, Mitchell, Braxton D., Morisaki, Takayuki, O’Donnell, Martin J., Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Schmidt, Carsten O., Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Tiwari, Hemant K., Wennberg, Patrik, Wilson, Peter W. F., Yang, Qiong, Yoon, Kyungheon, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Ikram, Mohammad A., Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Ruigrok, Ynte M., Bastarache, Lisa, Damrauer, Scott M., Rotter, Jerome I., Niiranen, Teemu J., Walters, Robin G., Owolabi, Mayowa O., Huffman, Jennifer E., Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie

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How human endogenous retroviruses interact with the microbiota in health and disease von Dopkins, Nicholas, O’Mara, Morgan M., Singh, Bhavya, Marston, Jez L., Bendall, Matthew L., Nixon, Douglas F.

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Tobacco smoking induces metabolic reprogramming of renal cell carcinoma von Reigle, James, Secic, Dina, Biesiada, Jacek, Wetzel, Collin, Shamsaei, Behrouz, Chu, Johnson, Zang, Yuanwei, Zhang, Xiang, Talbot, Nicholas J, Bischoff, Megan E, Zhang, Yongzhen, Thakar, Charuhas V, Gaitonde, Krishnanath, Sidana, Abhinav, Bui, Hai, Cunningham, John T, Zhang, Qing, Schmidt, Laura S, Linehan, W Marston, Medvedovic, Mario, Plas, David R, Figueroa, Julio A Landero, Meller, Jarek, Czyzyk-Krzeska, Maria F

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Treatment of superficial and perforator reflux and deep venous stenosis improves healing of chronic venous leg ulcers von Lawrence, Peter F., Hager, Eric S., Harlander-Locke, Michael P., Pace, Nicholas, Jayaraj, Arjun, Yohann, Avital, Kalbaugh, Corey, Marston, William, Kabnick, Lowell, Saqib, Naveed, Pouliot, Susan, Piccolo, Carmen, Kiguchi, Misaki, Peralta, Sotero, Motaganahalli, Raghu

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Additional file 4 of Ribosomal profiling of human endogenous retroviruses in healthy tissues von Dopkins, Nicholas, Singh, Bhavya, Michael, Stephanie, Zhang, Panpan, Marston, Jez L., Fei, Tongyi, Singh, Manvendra, Feschotte, Cedric, Collins, Nicholas, Bendall, Matthew L., Nixon, Douglas F.

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Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association von Soffer, Daniel E., Marston, Nicholas A., Maki, Kevin C., Jacobson, Terry A., Bittner, Vera A., Peña, Jessica M., Thanassoulis, George, Martin, Seth S., Kirkpatrick, Carol F., Virani, Salim S., Dixon, Dave L., Ballantyne, Christie M., Remaley, Alan T.

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology von Southam, Lorraine, Yin, Xianyong, Melloni, Giorgio E. M., Rayner, Nigel W., Bocher, Ozvan, Namba, Shinichi, Lee, Simon S. K., Petty, Lauren E., Schroeder, Philip, Kals, Mart, Zhang, Weihua, Graff, Mariaelisa, Lamri, Amel, Parra, Esteban J., Bielak, Lawrence F., Hai, Yang, Sofer, Tamar, Nousome, Darryl, Sun, Meng, Noordam, Raymond, Lim, Victor J. Y., Yanek, Lisa R., An, Ping, Tan, Jingyi, Canouil, Mickaël, Chee, Miao-Li, Chen, Shyh-Huei, Chen, Yuan-Tsong, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Eckardt, Kai-Uwe, Gerstein, Hertzel C., Han, Sohee, Herder, Christian, Howard, Annie-Green, Hsueh, Willa, Ichihara, Sahoko, Ikram, Mohammad Arfan, Jang, Hye-Mi, Jonas, Jost B., Kandeel, Fouad R., Kaur, Varinderpal, Lange, Leslie A., Lee, Myung-Shik, Leong, Aaron, Liu, Ching-Ti, Louie, Tin, Luo, Xi, Maeda, Shiro, Mansuri, Sohail Rafik, Nalls, Michael A., Nayak, Uma, Okada, Yukinori, Patil, Snehal, Prasad, Gauri, Roden, Michael, Rohde, Rebecca, Sandow, Kevin, Sankareswaran, Alagu, So, Wing Yee, Stilp, Adrienne M., Taylor, Kent D., Thorand, Barbara, Valladares-Salgado, Adan, Wheeler, Eleanor, Raffel, Leslie J., Igase, Michiya, Province, Michael A., Rotimi, Charles N., Peyser, Patricia A., Pankow, James S., Wilson, James G., Sheu, Wayne H. H., Mook-Kanamori, Dennis O., Collins, Francis S., Paré, Guillaume, Shu, Xiao-Ou, Dupuis, Josee, Kato, Norihiro, Laakso, Markku, Wareham, Nicholas J., Kim, Bong-Jo, Stefansson, Kari, Goodarzi, Mark O., Mohlke, Karen L., Florez, Jose C., Zöllner, Sebastian, Mägi, Reedik, van Heel, David A., Finer, Sarah, Ng, Maggie C. Y., Sim, Xueling, Below, Jennifer E., Chang, Kyong-Mi, Meigs, James B., Mahajan, Anubha, Vujkovic, Marijana, Voight, Benjamin F., Morris, Andrew P.

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Hepatic fat changes with antisense oligonucleotide therapy targeting ANGPTL3 von Zimerman, Andre, Wiviott, Stephen D., Park, Jeong-Gun, Murphy, Sabina A., Ran, Xinhui, Bramson, Candace R., Curto, Madelyn, Ramos, Vesper, Jevne, Alexandra, Kuder, Julia F., Verma, Subodh, Wojakowski, Wojtek, Terra, Steven G., Sabatine, Marc S., Bergmark, Brian A., Marston, Nicholas A.

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The genomics of heart failure: design and rationale of the HERMES consortium von Lumbers, R. Thomas, Shah, Sonia, Lin, Honghuang, Henry, Albert, Swerdlow, Daniel I., Holmes, Michael V., Ärnlöv, Johan, Sallah, Neneh, Asselin, Geraldine, Backman, Joshua D., Brandimarto, Jeffrey, Brunner‐La Rocca, Hans‐Peter, Chaffin, Mark D., Chazara, Olympe, Cleland, John G.F., Cook, James P., Denus, Simon, Dehghan, Abbas, Delgado, Graciela E., Denaxas, Spiros, Doney, Alexander S., Esko, Tõnu, Fatemifar, Ghazaleh, Ford, Ian, Ghasemi, Sahar, Giedraitis, Vilmantas, Giulianini, Franco, Gottdiener, John S., Gross, Stefan, Guðbjartsson, Daníel F., Hedman, Åsa K., Kamanu, Frederick, Khaw, Kay‐Tee, Kleber, Marcus E., Kuchenbaecker, Karoline, Lindgren, Cecilia M., Luan, Jian'an, Magnusson, Patrik, Mahajan, Anubha, Mann, Douglas, Margulies, Kenneth B., McMurray, John J.V., Melander, Olle, Mordi, Ify R., Morley, Michael P., Morris, Andrew D., Morris, Andrew P., Morrison, Alanna C., Nagle, Michael W., Nelson, Christopher P., Newton‐Cheh, Christopher, Niessner, Alexander, Niiranen, Teemu, Nowak, Christoph, O'Donoghue, Michelle L., Palmer, Colin N.A., Paré, Guillaume, Perreault, Louis‐Philippe Lemieux, Portilla‐Fernandez, Eliana, Rice, Kenneth M., Ridker, Paul M., Romaine, Simon P.R., Roselli, Carolina, Rotter, Jerome I., Ruff, Christian T., Sabatine, Marc S., Salomaa, Veikko, Setten, Jessica, Smelser, Diane T., Smith, Nicholas L., Stott, David J., Sveinbjörnsson, Garðar, Taylor, Kent D., Teder‐Laving, Maris, Teumer, Alexander, Thorsteinsdottir, Unnur, Torp‐Pedersen, Christian, Trompet, Stella, Tuckwell, Danny, Uitterlinden, Andre G., Vaura, Felix, Veluchamy, Abirami, Visscher, Peter M., Wareham, Nicholas J., Weiss, Raul, Xing, Heming, Yang, Jian, Yang, Yifan, Yerges‐Armstrong, Laura M., Zannad, Faiez, Holm, Hilma, Lanfear, David E., Dunn, Michael E., Wells, Quinn S., Asselbergs, Folkert W., Hingorani, Aroon D., Samani, Nilesh J., Lang, Chim C., Cappola, Thomas P., Smith, J. Gustav

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