Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress von Lam, Mable, Marsters, Scot A., Ashkenazi, Avi, Walter, Peter

Volltext

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate von Chang, Tsun-Kai, Lawrence, David A., Lu, Min, Tan, Jenille, Harnoss, Jonathan M., Marsters, Scot A., Liu, Peter, Sandoval, Wendy, Martin, Scott E., Ashkenazi, Avi

Volltext

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis von Lu, Min, Lawrence, David A., Marsters, Scot, Acosta-Alvear, Diego, Kimmig, Philipp, Mendez, Aaron S., Paton, Adrienne W., Paton, James C., Walter, Peter, Ashkenazi, Avi

Volltext

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α von Le Thomas, Adrien, Ferri, Elena, Marsters, Scot, Harnoss, Jonathan M., Lawrence, David A., Zuazo-Gaztelu, Iratxe, Modrusan, Zora, Chan, Sara, Solon, Margaret, Chalouni, Cécile, Li, Weihan, Koeppen, Hartmut, Rudolph, Joachim, Wang, Weiru, Wu, Thomas D., Walter, Peter, Ashkenazi, Avi

Volltext

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay von Cairrão, Fátima, Santos, Cristiana C., Le Thomas, Adrien, Marsters, Scot, Ashkenazi, Avi, Domingos, Pedro M.

Volltext

E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis von Lu, Min, Marsters, Scot, Ye, Xiaofen, Luis, Elizabeth, Gonzalez, Lino, Ashkenazi, Avi

Volltext

IRE1 alpha Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment von Harnoss, Jonathan M., Le Thomas, Adrien, Reichelt, Mike, Guttman, Ofer, Wu, Thomas D., Marsters, Scot A., Shemorry, Anna, Lawrence, David A., Kan, David, Segal, Ehud, Merchant, Mark, Totpal, Klara, Crocker, Lisa M., Mesh, Kathryn, Dohse, Monika, Solon, Margaret, Modrusan, Zora, Rudolph, Joachim, Koeppen, Hartmut, Walter, Peter, Ashkenazi, Avi

Volltext

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer von Montagut, Clara, Dalmases, Alba, Bellosillo, Beatriz, Crespo, Marta, Pairet, Silvia, Iglesias, Mar, Salido, Marta, Gallen, Manuel, Marsters, Scot, Tsai, Siao Ping, Minoche, André, Seshagiri, Somasekar, Serrano, Sergi, Himmelbauer, Heinz, Bellmunt, Joaquim, Rovira, Ana, Settleman, Jeff, Bosch, Francesc, Albanell, Joan

Volltext

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress von Shemorry, Anna, Harnoss, Jonathan M, Guttman, Ofer, Marsters, Scot A, Kőműves, László G, Lawrence, David A, Ashkenazi, Avi

Volltext

Disruption of IRE1α through its kinase domain attenuates multiple myeloma von Harnoss, Jonathan M., Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A., Lawrence, David A., Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Wallweber, Heidi Ackerly, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H., Laing, Steven T., Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M., Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J., Sherbenou, Daniel W., Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi

Volltext

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display von Nair, Pradeep M., Flores, Heather, Gogineni, Alvin, Marsters, Scot, Lawrence, David A., Kelley, Robert F., Ngu, Hai, Sagolla, Meredith, Komuves, Laszlo, Bourgon, Richard, Settleman, Jeffrey, Ashkenazi, Avi

Volltext

Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant von Wilson, Nicholas S, Duewell, Peter, Yang, Becky, Li, Yun, Marsters, Scot, Koernig, Sandra, Latz, Eicke, Maraskovsky, Eugene, Morelli, Adriana Baz, Schnurr, Max, Ashkenazi, Avi

Volltext

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors von Sheridan, James P., Marsters, Scot A., Pitti, Robert M., Gurney, Austin, Skubatch, Maya, Baldwin, Daryl, Ramakrishnan, Lakshmi, Gray, Christa L., Baker, Kevin, Wood, William I., Goddard, Audrey D., Godowski, Paul, Ashkenazi, Avi

Volltext

Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth von Wilson, Nicholas S., Yang, Annie, Yang, Becky, Couto, Suzana, Stern, Howard, Gogineni, Alvin, Pitti, Robert, Marsters, Scot, Weimer, Robby M., Singh, Mallika, Ashkenazi, Avi

Volltext

Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4 von Chuntharapai, Anan, Dodge, Kelly, Grimmer, Katharine, Schroeder, Kurt, Marsters, Scot A, Koeppen, Hartmut, Ashkenazi, Avi, Kim, K. Jin

Volltext

ATF6 promotes colorectal cancer growth and stemness by regulating the Wnt pathway von Rodvold, Jeffrey J, Grimmer, Matthew, Ruiz, Karen, Marsters, Scot A, Oikonomidi, Ioanna, Tan-Aristy, Eileen, Pham, Victoria C, Sarkar, Tamal, Harnoss, Jonathan M, Shatz-Binder, Whitney, Modrusan, Zora D, Wu, Thomas D, Lill, Jennie R, Villemure, Elisia, Rudolph, Joachim, de Sousa E Melo, Felipe, Ashkenazi, Avi

Volltext

Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI von Marsters, Scot A, Yan, Minhong, Pitti, Robert M, Haas, Philip E, Dixit, Vishva M, Ashkenazi, Avi

Volltext

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity von Ashkenazi, Avi, Dixit, Vishva M, Yan, Minhong, Marsters, Scot A, Grewal, Iqbal S, Wang, Hua

Volltext

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions von Lawrence, David, Shahrokh, Zahra, Marsters, Scot, Achilles, Kirsten, Shih, Danny, Mounho, Barbara, Hillan, Kenneth, Totpal, Klara, DeForge, Laura, Schow, Peter, Hooley, Jeffrey, Sherwood, Steve, Pai, Roger, Leung, Susan, Khan, Lolo, Gliniak, Brian, Bussiere, Jeanine, Smith, Craig A, Strom, Stephen S, Kelley, Sean, Fox, Judith A, Thomas, Deborah, Ashkenazi, Avi

Volltext

Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey von Zuch de Zafra, Christina L, Ashkenazi, Avi, Darbonne, Walter C, Cheu, Melissa, Totpal, Klara, Ortega, Shirley, Flores, Heather, Walker, Mark D, Kabakoff, Bruce, Lum, Bert L, Mounho-Zamora, Barbara J, Marsters, Scot A, Dybdal, Noël O

Volltext