A genetics-led approach defines the drug target landscape of 30 immune-related traits von Fang, Hai, De Wolf, Hans, Knezevic, Bogdan, Burnham, Katie L., Osgood, Julie, Sanniti, Anna, Lledó Lara, Alicia, Kasela, Silva, De Cesco, Stephane, Wegner, Jörg K., Handunnetthi, Lahiru, McCann, Fiona E., Chen, Liye, Sekine, Takuya, Brennan, Paul E., Marsden, Brian D., Damerell, David, O’Callaghan, Chris A., Bountra, Chas, Bowness, Paul, Sundström, Yvonne, Milani, Lili, Berg, Louise, Göhlmann, Hinrich W., Peeters, Pieter J., Fairfax, Benjamin P., Sundström, Michael, Knight, Julian C.

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Chemical Screening Methods to Identify Ligands That Promote Protein Stability, Protein Crystallization, and Structure Determination von Vedadi, Masoud, Niesen, Frank H., Allali-Hassani, Abdellah, Fedorov, Oleg Y., Finerty, Patrick J., Wasney, Gregory A., Yeung, Ron, Arrowsmith, Cheryl, Ball, Linda J., Berglund, Helena, Hui, Raymond, Marsden, Brian D., Nordlund, Pär, Sundstrom, Michael, Weigelt, Johan, Edwards, Aled M.

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Target 2035 - update on the quest for a probe for every protein von Müller, Susanne, Ackloo, Suzanne, Al Chawaf, Arij, Al-Lazikani, Bissan, Antolin, Albert, Baell, Jonathan B, Beck, Hartmut, Beedie, Shaunna, Betz, Ulrich A K, Bezerra, Gustavo Arruda, Brennan, Paul E, Brown, David, Brown, Peter J, Bullock, Alex N, Carter, Adrian J, Chaikuad, Apirat, Chaineau, Mathilde, Ciulli, Alessio, Collins, Ian, Dreher, Jan, Drewry, David, Edfeldt, Kristina, Edwards, Aled M, Egner, Ursula, Frye, Stephen V, Fuchs, Stephen M, Hall, Matthew D, Hartung, Ingo V, Hillisch, Alexander, Hitchcock, Stephen H, Homan, Evert, Kannan, Natarajan, Kiefer, James R, Knapp, Stefan, Kostic, Milka, Kubicek, Stefan, Leach, Andrew R, Lindemann, Sven, Marsden, Brian D, Matsui, Hisanori, Meier, Jordan L, Merk, Daniel, Michel, Maurice, Morgan, Maxwell R, Mueller-Fahrnow, Anke, Owen, Dafydd R, Perry, Benjamin G, Rosenberg, Saul H, Saikatendu, Kumar Singh, Schapira, Matthieu, Scholten, Cora, Sharma, Sujata, Simeonov, Anton, Sundström, Michael, Superti-Furga, Giulio, Todd, Matthew H, Tredup, Claudia, Vedadi, Masoud, von Delft, Frank, Willson, Timothy M, Winter, Georg E, Workman, Paul, Arrowsmith, Cheryl H

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Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase von Bullock, Alex N, Debreczeni, Judit É, Fedorov, Oleg Y, Nelson, Adam, Marsden, Brian D, Knapp, Stefan

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High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging von Chen, J, Sivan, U, Tan, SL, Lippo, L, De Angelis, J, Labella, R, Singh, A, Chatzis, A, Cheuk, S, Medhghalchi, M, Gil, J, Hollander, G, Marsden, BD, Williams, R, Ramasamy, SK, Kusumbe, AP

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Disseminating structural genomics data to the public: from a data dump to an animated story von Abagyan, Ruben, Lee, Wen Hwa, Raush, Eugene, Budagyan, Levon, Totrov, Maxim, Sundstrom, Michael, Marsden, Brian D.

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A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression von Nentwich, Hilke A, Mustafa, Zehra, Rugg, Marilyn S, Marsden, Brian D, Cordell, Martin R, Mahoney, David J, Jenkins, Suzanne C, Dowling, Barbara, Fries, Erik, Milner, Caroline M, Loughlin, John, Day, Anthony J

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Gas Phase Characterization of the Noncovalent Quaternary Structure of Cholera Toxin and the Cholera Toxin B Subunit Pentamer von Williams, Jonathan P., Smith, Daniel C., Green, Brian N., Marsden, Brian D., Jennings, Keith R., Roberts, Lynne M., Scrivens, James H.

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Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity von West, CE, Karim, M, Falaguera, MJ, Speidel, L, Green, CJ, Logie, L, Schwartzentruber, J, Ochoa, D, Lord, JM, Ferguson, MAJ, Bountra, C, Wilkinson, GF, Vaughan, B, Leach, AR, Dunham, I, Marsden, BD

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SARS-CoV-2 anti-spike IgG antibody responses after second dose of ChAdOx1 or BNT162b2 and correlates of protection in the UK general population von Wei, J, Pouwels, K, Stoesser, N, Matthews, P, Diamond, I, Studley, R, Rourke, E, Cook, D, Bell, JI, Newton, JN, Farrar, J, Howarth, A, Marsden, BD, Hoosdally, S, Jones, EY, Stuart, DI, Crook, DW, Peto, TEA, Walker, A, Eyre, DW

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Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status von Eyre, DW, Lumley, SF, Wei, J, Cox, S, James, T, Justice, A, Jesuthasan, G, O'Donnell, D, Howarth, A, Hatch, SB, Marsden, BD, Jones, YE, Stuart, DI, Ebner, D, Hoosdally, S, Crook, D, Peto, T, Walker, T, Stoesser, N, Matthews, P, Pouwels, KB, Walker, A, Jeffery, K

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Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom von Wei, J, Stoesser, N, Matthews, P, Ayoubkhani, D, Studley, R, Bell, I, Bell, JI, Newton, JN, Farrar, J, Diamond, I, Rourke, E, Howarth, A, Marsden, BD, Hoosdally, S, Jones, EY, Stuart, DI, Crook, DW, Peto, TEA, Pouwels, KB, Eyre, D, Walker, A

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Anti-spike antibody response to natural SARS-CoV-2 infection in the general population von Wei, J, Matthews, PC, Stoesser, N, Maddox, T, Lorenzi, L, Studley, R, Bell, JI, Newton, JN, Farrar, J, Diamond, I, Rourke, E, Howarth, A, Marsden, BD, Hoosdally, S, Jones, EY, Stuart, DI, Crook, DW, Peto, TEA, Pouwels, KB, Walker, A, Eyre, DW, the COVID-19 Infection Survey team

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Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers von Lumley, SF, O'Donnell, D, Stoesser, NE, Matthews, PC, Howarth, A, Hatch, SB, Marsden, BD, Cox, S, James, T, Warren, F, Peck, LJ, Ritter, TG, de Toledo, Z, Warren, L, Axten, D, Cornall, RJ, Jones, EY, Stuart, DI, Screaton, G, Ebner, D, Hoosdally, S, Chand, M, Crook, DW, O'Donnell, A-M, Conlon, CP, Pouwels, KB, Walker, AS, Peto, TEA, Hopkins, S, Walker, TM, Jeffery, K, Eyre, DW, Oxford University Hospitals Staff Testing Group

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Target 2035-update on the quest for a probe for every protein von Mueller, S, Ackloo, S, Al Chawaf, A, Al-Lazikani, B, Antolin, A, Baell, JB, Beck, H, Beedie, S, Betz, UAK, Bezerra, GA, Brennan, PE, Brown, D, Brown, PJ, Bullock, AN, Carter, AJ, Chaikuad, A, Chaineau, M, Ciulli, A, Collins, I, Dreher, J, Drewry, D, Edfeldt, K, Edwards, AM, Egner, U, Frye, S, Fuchs, SM, Hall, MD, Hartung, I, Hillisch, A, Hitchcock, SH, Homan, E, Kannan, N, Kiefer, JR, Knapp, S, Kostic, M, Kubicek, S, Leach, AR, Lindemann, S, Marsden, BD, Matsui, H, Meier, JL, Merk, D, Michel, M, Morgan, MR, Mueller-Fahrnow, A, Owen, DR, Perry, BG, Rosenberg, SH, Saikatendu, KS, Schapira, M, Scholten, C, Sharma, S, Simeonov, A, Sundstrom, M, Superti-Furga, G, Todd, MH, Tredup, C, Vedadi, M, von Delft, F, Willson, TM, Winter, GE, Workman, P, Arrowsmith, CH

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Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers von Zuliani-Alvarez, L, Marzeda, AM, Deligne, C, Schwenzer, A, McCann, FE, Marsden, BD, Piccinini, AM, Midwood, KS

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Dynamo processes and activity cycles of the active stars AB Doradus, LQ Hydrae and HR 1099 von Donati, J.-F., Cameron, A. Collier, Semel, M., Hussain, G. A. J., Petit, P., Carter, B. D., Marsden, S. C., Mengel, M., Ariste, A. López, Jeffers, S. V., Rees, D. E.

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Doppler imaging and surface differential rotation of young open cluster stars – I. HD 307938 (R58) in IC 2602 von Marsden, S. C., Waite, I. A., Carter, B. D., Donati, J.-F.

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Supportive evidence for the potential for novel biodiscovery in osteoarthritis through the STEpUP OA consortium von Perry, TA, Deng, Y, Hulley, P, Maciewicz, RA, Mitchelmore, J, Perry, D, Larsson, S, Lemire, S, Struglics, A, Appleton, CT, Kluzek, S, Arden, NK, Felson, DT, Marsden, B, Tom, BD, Bondi, L, Kapoor, M, Kumar, V, Lohmander, LS, Welting, TJ, Walsh, DA, Valdes, AM, Jostins-Dean, L, Watt, FE, Vincent, TL

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Surface differential rotation and prominences of the Lupus post T Tauri star RX J1508.6-4423 von Donati, J.-F., Mengel, M., Carter, B. D., Marsden, S., Collier Cameron, A., Wichmann, R.

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