Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery von Marsault, Eric, Peterson, Mark L

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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic von Shapira, Tirosh, Monreal, I. Abrrey, Dion, Sébastien P., Buchholz, David W., Imbiakha, Brian, Olmstead, Andrea D., Jager, Mason, Désilets, Antoine, Gao, Guang, Martins, Mathias, Vandal, Thierry, Thompson, Connor A. H., Chin, Aaleigha, Rees, William D., Steiner, Theodore, Nabi, Ivan Robert, Marsault, Eric, Sahler, Julie, Diel, Diego G., Van de Walle, Gerlinde R., August, Avery, Whittaker, Gary R., Boudreault, Pierre-Luc, Leduc, Richard, Aguilar, Hector C., Jean, François

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Localized apelin-17 analogue-bicelle interactions as a facilitator of membrane-catalyzed receptor recognition and binding von Phạm, Trần Thanh Tâm, Murza, Alexandre, Marsault, Éric, Frampton, John P., Rainey, Jan K.

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Discovery of a CCR2-targeting pepducin therapy for chronic pain von Midavaine, Élora, Brouillette, Rebecca L., Théberge, Elizabeth, Mona, Christine E., Kashem, Sakeen W., Côté, Jérôme, Zeugin, Vera, Besserer-Offroy, Élie, Longpré, Jean-Michel, Marsault, Éric, Sarret, Philippe

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Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C von Lamontagne Boulet, Maxime, Isabelle, Charles, Guay, Isabelle, Brouillette, Eric, Langlois, Jean-Philippe, Jacques, Pierre-Étienne, Rodrigue, Sébastien, Brzezinski, Ryszard, Beauregard, Pascale B, Bouarab, Kamal, Boyapelly, Kumaraswamy, Boudreault, Pierre-Luc, Marsault, Éric, Malouin, François

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ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock von Coquerel, David, Chagnon, Frédéric, Sainsily, Xavier, Dumont, Lauralyne, Murza, Alexandre, Côté, Jérôme, Dumaine, Robert, Sarret, Philippe, Marsault, Éric, Salvail, Dany, Auger-Messier, Mannix, Lesur, Olivier

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The signaling signature of the neurotensin type 1 receptor with endogenous ligands von Besserer-Offroy, Élie, Brouillette, Rebecca L., Lavenus, Sandrine, Froehlich, Ulrike, Brumwell, Andrea, Murza, Alexandre, Longpré, Jean-Michel, Marsault, Éric, Grandbois, Michel, Sarret, Philippe, Leduc, Richard

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Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles von L'Exact, Marion, Comeau, Christian, Bourhis, Alix, Boisvert, Olivier, Fröhlich, Ulrike, Létourneau, Danny, Marsault, Éric, Lavigne, Pierre, Grandbois, Michel, Boudreault, Pierre-Luc

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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes von Béliveau, François, Tarkar, Aarti, Dion, Sébastien P., Désilets, Antoine, Ghinet, Mariana Gabriela, Boudreault, Pierre-Luc, St-Georges, Catherine, Marsault, Éric, Paone, Daniel, Collins, Jon, Macphee, Colin H., Campobasso, Nino, Groy, Arthur, Cottom, Josh, Ouellette, Michael, Pope, Andrew J., Leduc, Richard

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Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients von Coquerel, David, Lamoureux, Julie, Chagnon, Frédéric, Trân, Kien, Sage, Michael, Fortin-Pellerin, Etienne, Delile, Eugénie, Sainsily, Xavier, Fournier, Justin, Dumont, Audrey-Ann, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Eric, Praud, Jean-Paul, Fülöp, Tamàs, Lesur, Olivier

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Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium von Beaulieu, Alexandre, Gravel, Émilie, Cloutier, Alexandre, Marois, Isabelle, Colombo, Éloïc, Désilets, Antoine, Verreault, Catherine, Leduc, Richard, Marsault, Éric, Richter, Martin V

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Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor von Trân, Kien, Murza, Alexandre, Sainsily, Xavier, Delile, Eugénie, Couvineau, Pierre, Côté, Jérôme, Coquerel, David, Peloquin, Maude, Auger-Messier, Mannix, Bouvier, Michel, Lesur, Olivier, Sarret, Philippe, Marsault, Éric

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Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcu... von Langlois, Jean-Philippe, Millette, Guillaume, Guay, Isabelle, Dubé-Duquette, Alexis, Chamberland, Suzanne, Jacques, Pierre-Étienne, Rodrigue, Sébastien, Bouarab, Kamal, Marsault, Éric, Malouin, François

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The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection von Traboulsi, Hussein, Cloutier, Alexandre, Boyapelly, Kumaraswamy, Bonin, Marc-André, Marsault, Éric, Cantin, André M, Richter, Martin V

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Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake von Sainsily, Xavier, Coquerel, David, Giguère, Hugo, Dumont, Lauralyne, Tran, Kien, Noll, Christophe, Ionescu, Andrei L., Côté, Jérôme, Longpré, Jean-Michel, Carpentier, André, Marsault, Éric, Lesur, Olivier, Sarret, Philippe, Auger-Messier, Mannix

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Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule... von Boulanger, Simon, Mitchell, Gabriel, Bouarab, Kamal, Marsault, Éric, Cantin, André, Frost, Eric H, Déziel, Eric, Malouin, François

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Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties von Demeule, Michel, Beaudet, Nicolas, Régina, Anthony, Besserer-Offroy, Élie, Murza, Alexandre, Tétreault, Pascal, Belleville, Karine, Ché, Christian, Larocque, Alain, Thiot, Carine, Béliveau, Richard, Longpré, Jean-Michel, Marsault, Éric, Leduc, Richard, Lachowicz, Jean E, Gonias, Steven L, Castaigne, Jean-Paul, Sarret, Philippe

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Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression von Mitchell, Gabriel, Lafrance, Myriame, Boulanger, Simon, Séguin, David Lalonde, Guay, Isabelle, Gattuso, Mariza, Marsault, Éric, Bouarab, Kamal, Malouin, François

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The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment von Besserer-Offroy, Élie, Bérubé, Patrick, Côté, Jérôme, Murza, Alexandre, Longpré, Jean-Michel, Dumaine, Robert, Lesur, Olivier, Auger-Messier, Mannix, Leduc, Richard, Marsault, Éric, Sarret, Philippe

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Structure-activity relationship of novel macrocyclic biased apelin receptor agonists von Murza, Alexandre, Sainsily, Xavier, Côté, Jérôme, Bruneau-Cossette, Laurent, Besserer-Offroy, Élie, Longpré, Jean-Michel, Leduc, Richard, Dumaine, Robert, Lesur, Olivier, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Éric

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