MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis von Marjon, Katya, Cameron, Michael J., Quang, Phong, Clasquin, Michelle F., Mandley, Everton, Kunii, Kaiko, McVay, Michael, Choe, Sung, Kernytsky, Andrew, Gross, Stefan, Konteatis, Zenon, Murtie, Joshua, Blake, Michelle L., Travins, Jeremy, Dorsch, Marion, Biller, Scott A., Marks, Kevin M.

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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage von Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A

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Chemical labeling strategies for cell biology von Nolan, Garry P, Marks, Kevin M

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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition von Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer von Possemato, Richard, Marks, Kevin M., Shaul, Yoav D., Pacold, Michael E., Kim, Dohoon, Birsoy, Kıvanç, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing, Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Sabatini, David M.

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The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes von Marks, Kevin M, Park, Eun Sun, Arefolov, Alexander, Russo, Katie, Ishihara, Keiko, Ring, Jennifer E, Clardy, Jon, Clarke, Astrid S, Pelish, Henry E

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Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion von Konteatis, Zenon, Travins, Jeremy, Gross, Stefan, Marjon, Katya, Barnett, Amelia, Mandley, Everton, Nicolay, Brandon, Nagaraja, Raj, Chen, Yue, Sun, Yabo, Liu, Zhixiao, Yu, Jie, Ye, Zhixiong, Jiang, Fan, Wei, Wentao, Fang, Cheng, Gao, Yi, Kalev, Peter, Hyer, Marc L, DeLaBarre, Byron, Jin, Lei, Padyana, Anil K, Dang, Lenny, Murtie, Joshua, Biller, Scott A, Sui, Zhihua, Marks, Kevin M

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A General Approach for Chemical Labeling and Rapid, Spatially Controlled Protein Inactivation von Marks, Kevin M., Braun, Patrick D., Nolan, Garry P., Mak, Tak Wah

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Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads von Li, Mingzong, Konteatis, Zenon, Nagaraja, Nelamangala, Chen, Yue, Zhou, Shubao, Ma, Guangning, Gross, Stefan, Marjon, Katya, Hyer, Marc L, Mandley, Everton, Lein, Max, Padyana, Anil K, Jin, Lei, Tong, Shuilong, Peters, Rachel, Murtie, Joshua, Travins, Jeremy, Medeiros, Matthew, Liu, Peng, Frank, Victoria, Judd, Evan T, Biller, Scott A, Marks, Kevin M, Sui, Zhihua, Reznik, Samuel K

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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase von McDonald, Gabrielle, Chubukov, Victor, Coco, John, Truskowski, Kevin, Narayanaswamy, Rohini, Choe, Sung, Steadman, Mya, Artin, Erin, Padyana, Anil K., Jin, Lei, Ronseaux, Sebastien, Locuson, Charles, Fan, Zi-Peng, Erdmann, Tabea, Mann, Alan, Hayes, Sebastian, Fletcher, Mark, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Reddy, K. Satish, Panigrahi, Sunil K., Antony, Thomas, Gopinath, Sreevalsam, Sui, Zhihua, Nagaraja, Nelamangala, Dang, Lenny, Lenz, Georg, Hurov, Jonathan, Biller, Scott A., Murtie, Josh, Marks, Kevin M., Ulanet, Danielle B.

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Abstract B115: Mitotic defects induced by MAT2A inhibitors guides translational drug combination strategies with AG-270 and taxanes von Kalev, Peter, Hyer, Marc L, Fletcher, Mark, Zhang, Peili, Aguado-Fraile, Elia, Mandley, Everton, Tuncay, Yesim, Konteatis, Zenon, Travins, Jeremy, Marks, Kevin M, Marjon, Katya

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Abstract 3090: The MAT2A inhibitor, AG-270, combines with both taxanes and gemcitabine to yield enhanced anti-tumor activity in patient-derived xenograft models von Hyer, Marc L., Kalev, Peter, Fletcher, Mark, Chen, Chi-Chao, Aguado-Fraile, Elia, Mandley, Everton, Newhouse, Sheila, Lein, Max, Nagaraja, Raj, Tuncay, Yesim, Murtie, Josh, Marks, Kevin M., Marjon, Katya

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In Vivo Targeting of Organic Calcium Sensors via Genetically Selected Peptides von Marks, Kevin M., Rosinov, Michael, Nolan, Garry P.

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer von Possemato, Richard, Marks, Kevin M, Shaul, Yoav D, Pacold, Michael E, Kim, Dohoon, Birsoy, Kivanc, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G, Jha, Abhishek K, Chen, Walter W, Barrett, Francesca G, Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S, Barretina, Jordi, Kalaany, Nada Y, Hsu, Peggy P, Ottina, Kathleen, Chan, Albert M, Yuan, Bingbing, Brachtel, Lev Elena F, Driggers, Edward M, Sabatini, David M

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Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer von Possemato, Richard, Marks, Kevin M., Shaul, Yoav D., Pacold, Michael E., Kim, Dohoon, Birsoy, Kivanç, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing, Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Sabatini, David M.

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Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Fantin, Valeria R., Dang, Lenny, White, David W., Gross, Stefan, Bittinger, Mark A., Driggers, Edward M., Jang, Hyun Gyung, Jin, Shengfang, Keenan, Marie C., Marks, Kevin M., Yen, Katharine E., Ward, Patrick S., Prins, Robert M., Liau, Linda M., Bennett, Bryson D., Rabinowitz, Joshua D., Cantley, Lewis C., Thompson, Craig B., Heiden, Matthew Vander, Su, Shinsan M.

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Where has all the lorazepam gone? von de Monteverde-Robb, David J S

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Electronic device with millimeter wave antennas on stacked printed circuits von Mow, Matthew A, Tsai, Ming-Ju, Noori, Basim H, Caballero, Ruben, Ouyang, Yuehui, Shiu, Boon W, Marks, Kevin M, Salam, Khan, Pascolini, Mattia

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