Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids von Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David M.

Volltext

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism von Jain, Isha H., Calvo, Sarah E., Markhard, Andrew L., Skinner, Owen S., To, Tsz-Leung, Ast, Tslil, Mootha, Vamsi K.

Volltext

Architecture of the mitochondrial calcium uniporter von Oxenoid, Kirill, Dong, Ying, Cao, Chan, Cui, Tanxing, Sancak, Yasemin, Markhard, Andrew L., Grabarek, Zenon, Kong, Liangliang, Liu, Zhijun, Ouyang, Bo, Cong, Yao, Mootha, Vamsi K., Chou, James J.

Volltext

Hepatic NADH reductive stress underlies common variation in metabolic traits von Goodman, Russell P., Markhard, Andrew L., Shah, Hardik, Sharma, Rohit, Skinner, Owen S., Clish, Clary B., Deik, Amy, Patgiri, Anupam, Hsu, Yu-Han H., Masia, Ricard, Noh, Hye Lim, Suk, Sujin, Goldberger, Olga, Hirschhorn, Joel N., Yellen, Gary, Kim, Jason K., Mootha, Vamsi K.

Volltext

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex von Sancak, Yasemin, Markhard, Andrew L., Kitami, Toshimori, Kovács-Bogdán, Erika, Kamer, Kimberli J., Udeshi, Namrata D., Carr, Steven A., Chaudhuri, Dipayan, Clapham, David E., Li, Andrew A., Calvo, Sarah E., Goldberger, Olga, Mootha, Vamsi K.

Volltext

Hypoxia extends lifespan and neurological function in a mouse model of aging von Rogers, Robert S, Wang, Hong, Durham, Timothy J, Stefely, Jonathan A, Owiti, Norah A, Markhard, Andrew L, Sandler, Lev, To, Tsz-Leung, Mootha, Vamsi K

Volltext

Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation von Ganetzky, Rebecca D., Markhard, Andrew L., Yee, Irene, Clever, Sheila, Cahill, Alan, Shah, Hardik, Grabarek, Zenon, To, Tsz-Leung, Mootha, Vamsi K.

Volltext

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB von Sarbassov, Dos D., Ali, Siraj M., Sengupta, Shomit, Sheen, Joon-Ho, Hsu, Peggy P., Bagley, Alex F., Markhard, Andrew L., Sabatini, David M.

Volltext

A genetically encoded system for oxygen generation in living cells von Markhard, Andrew L., McCoy, Jason G., To, Tsz-Leung, Mootha, Vamsi K.

Volltext

Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae von Markowitz, Tovah E, Suarez, Daniel, Blitzblau, Hannah G, Patel, Neem J, Markhard, Andrew L, MacQueen, Amy J, Hochwagen, Andreas

Volltext

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapa... von Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A, Thoreen, Carson C, Markhard, Andrew, Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Sabatini, David M, Gray, Nathanael S

Volltext

ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits von Singh, Charandeep, Jin, Byungchang, Shrestha, Nirajan, Markhard, Andrew L., Panda, Apekshya, Calvo, Sarah E., Deik, Amy, Pan, Xingxiu, Zuckerman, Austin L., Ben Saad, Amel, Corey, Kathleen E., Sjoquist, Julia, Osganian, Stephanie, AminiTabrizi, Roya, Rhee, Eugene P., Shah, Hardik, Goldberger, Olga, Mullen, Alan C., Cracan, Valentin, Clish, Clary B., Mootha, Vamsi K., Goodman, Russell P.

Volltext

PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity von Wei, Wei, Lyu, Xuchao, Markhard, Andrew L., Fu, Sipei, Mardjuki, Rachel E., Cavanagh, Peter E., Zeng, Xianfeng, Rajniak, Jakub, Lu, Nannan, Xiao, Shuke, Zhao, Meng, Moya-Garzon, Maria Dolores, Truong, Steven D., Chou, Jonathan Chiu‐Chun, Wat, Lianna W., Chidambaranathan-Reghupaty, Saranya, Coassolo, Laetitia, Xu, Duo, Shen, Fangfang, Huang, Wentao, Ramirez, Cuauhtemoc B., Jang, Cholsoon, Li, Lingyin, Svensson, Katrin J., Fischbach, Michael A., Long, Jonathan Z.

Volltext

Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU von MacEwen, Melissa Js, Markhard, Andrew L, Bozbeyoglu, Mert, Bradford, Forrest, Goldberger, Olga, Mootha, Vamsi K, Sancak, Yasemin

Volltext

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism von Jain, Isha H., Calvo, Sarah E., Markhard, Andrew L., Skinner, Owen S., To, Tsz-Leung, Ast, Tslil, Mootha, Vamsi K.

Volltext

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism von Jain, Isha H., Calvo, Sarah E., Markhard, Andrew L., Skinner, Owen S., To, Tsz-Leung, Ast, Tslil, Mootha, Vamsi K.

Volltext

Hypoxia extends lifespan and neurological function in a mouse model of aging von Robert S. Rogers, Hong Wang, Timothy J. Durham, Jonathan A. Stefely, Norah A. Owiti, Andrew L. Markhard, Lev Sandler, Tsz-Leung To, Vamsi K. Mootha

Volltext

Architecture of the Mitochondrial Calcium Uniporter von Oxenoid, Kirill, Dong, Ying, Cao, Chan, Cui, Tanxing, Sancak, Yasemin, Markhard, Andrew L, Grabarek, Zenon, Kong, Liangliang, Liu, Zhijun, Ouyang, Bo, Cong, Yao, Mootha, Vamsi K, Chou, James J

Volltext

Development of ATP-Competitive mTOR Inhibitors von Liu, Qingsong, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Wang, Jinhua, Chang, Jae Won, Markhard, Andrew, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.

Volltext