Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial von Zakrzewska, Joanna M, Prof, Palmer, Joanne, PhD, Morisset, Valerie, PhD, Giblin, Gerard MP, PhD, Obermann, Mark, MD, Ettlin, Dominik A, MD, Cruccu, Giorgio, Prof, Bendtsen, Lars, MD, Estacion, Mark, PhD, Derjean, Dominique, PhD, Waxman, Stephen G, Prof, Layton, Gary, MSc, Gunn, Kevin, MD, Tate, Simon, PhD

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Gain-of-function mutations in sodium channel Nav1.9 in painful neuropathy von JIANYING HUANG, CHONGYANG HAN, MERKIES, Ingemar S. J, WAXMAN, Stephen G, ESTACION, Mark, VASYLYEV, Dymtro, HOEIJMAKERS, Janneke G. J, GERRITS, Monique M, TYRRELL, Lynda, LAURIA, Giuseppe, FABER, Catharina G, DIB-HAJJ, Sulayman D

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Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability von Ghovanloo, Mohammad‐Reza, Estacion, Mark, Higerd‐Rusli, Grant P., Zhao, Peng, Dib‐Hajj, Sulayman, Waxman, Stephen G.

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Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy von Faber, Catharina G., Hoeijmakers, Janneke G. J., Ahn, Hye-Sook, Cheng, Xiaoyang, Han, Chongyang, Choi, Jin-Sung, Estacion, Mark, Lauria, Giuseppe, Vanhoutte, Els K., Gerrits, Monique M., Dib-Hajj, Sulayman, Drenth, Joost P. H., Waxman, Stephen G., Merkies, Ingemar S. J.

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release von Alexandrou, Aristos J, Brown, Adam R, Chapman, Mark L, Estacion, Mark, Turner, Jamie, Mis, Malgorzata A, Wilbrey, Anna, Payne, Elizabeth C, Gutteridge, Alex, Cox, Peter J, Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E, West, Christopher, Swain, Nigel A, Storer, R Ian, Stupple, Paul A, Castle, Neil A, Hounshell, James A, Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D, Krafte, Douglas, Waxman, Stephen G, Patel, Manoj K, Butt, Richard P, Stevens, Edward B

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A novel de novo mutation of SCN8A (Nav 1.6) with enhanced channel activation in a child with epileptic encephalopathy von Estacion, Mark, O'Brien, Janelle E, Conravey, Allison, Hammer, Michael F, Waxman, Stephen G, Dib-Hajj, Sulayman D, Meisler, Miriam H

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Dexpramipexole blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models von Urru, Matteo, Muzzi, Mirko, Coppi, Elisabetta, Ranieri, Giuseppe, Buonvicino, Daniela, Camaioni, Emidio, Coppini, Raffaele, Pugliese, Anna Maria, Tanaka, Brian, Estacion, Mark, Waxman, Stephen G., Dib-Hajj, Sulayman D., Chiarugi, Alberto

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Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability von Estacion, Mark, Liu, Shujun, Cheng, Xiaoyang, Dib-Hajj, Sulayman, Waxman, Stephen G

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Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons von Alsaloum, Matthew, Labau, Julie I. R., Liu, Shujun, Estacion, Mark, Zhao, Peng, Dib-Hajj, Fadia, Waxman, Stephen G.

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A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons von Estacion, Mark, Gasser, Andreas, Dib-Hajj, Sulayman D., Waxman, Stephen G.

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A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia von Fischer, Tanya Z., Gilmore, Elaine S., Estacion, Mark, Eastman, Emmanuella, Taylor, Sean, Melanson, Michel, Dib-Hajj, Sulayman D., Waxman, Stephen G.

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A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain von Huang, Jianying, Estacion, Mark, Zhao, Peng, Dib-Hajj, Fadia B., Schulman, Betsy, Abicht, Angela, Kurth, Ingo, Brockmann, Knut, Waxman, Stephen G., Dib-Hajj, Sulayman D.

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Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation von Huang, Jianying, Mis, Malgorzata A., Tanaka, Brian, Adi, Talia, Estacion, Mark, Liu, Shujun, Walker, Suellen, Dib-Hajj, Sulayman D., Waxman, Stephen G.

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Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore von Labau, Julie I. R., Alsaloum, Matthew, Estacion, Mark, Tanaka, Brian, Dib-Hajj, Fadia B., Lauria, Giuseppe, Smeets, Hubert J. M., Faber, Catharina G., Dib-Hajj, Sulayman, Waxman, Stephen G.

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Identification and localization of TRPC channels in the rat kidney von Goel, Monu, Sinkins, William G, Zuo, Cheng-Di, Estacion, Mark, Schilling, William P

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Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability von Estacion, Mark, Sinkins, William G., Jones, Stephen W., Applegate, Milana A. B., Schilling, William P.

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Association of Immunophilins with Mammalian TRPC Channels von Sinkins, William G, Goel, Monu, Estacion, Mark, Schilling, William P

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Effects of Ranolazine on Wild-Type and Mutant hNav1.7 Channels and on DRG Neuron Excitability von Estacion, Mark, Waxman, Stephen G, Dib-Hajj, Sulayman D

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Activation of Human TRPC6 Channels by Receptor Stimulation von Estacion, Mark, Li, Su, Sinkins, William G, Gosling, Martin, Bahra, Parmjit, Poll, Chris, Westwick, John, Schilling, William P

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Palytoxin-induced cell death cascade in bovine aortic endothelial cells von Schilling, William P, Snyder, Deborah, Sinkins, William G, Estacion, Mark

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