Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population von Verma, Shefali S, Keat, Karl, Li, Binglan, Hoffecker, Glenda, Risman, Marjorie, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Dudek, Scott, Verma, Anurag, Klein, Teri E, Ritchie, Marylyn D, Tuteja, Sony

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Exome Sequencing in Suspected Monogenic Dyslipidemias von Stitziel, Nathan O, Peloso, Gina M, Abifadel, Marianne, Cefalu, Angelo B, Fouchier, Sigrid, Motazacker, M Mahdi, Tada, Hayato, Larach, Daniel B, Awan, Zuhier, Haller, Jorge F, Pullinger, Clive R, Varret, Mathilde, Rabès, Jean-Pierre, Noto, Davide, Tarugi, Patrizia, Kawashiri, Masa-aki, Nohara, Atsushi, Yamagishi, Masakazu, Risman, Marjorie, Deo, Rahul, Ruel, Isabelle, Shendure, Jay, Nickerson, Deborah A, Wilson, James G, Rich, Stephen S, Gupta, Namrata, Farlow, Deborah N, Neale, Benjamin M, Daly, Mark J, Kane, John P, Freeman, Mason W, Genest, Jacques, Rader, Daniel J, Mabuchi, Hiroshi, Kastelein, John J.P, Hovingh, G Kees, Averna, Maurizio R, Gabriel, Stacey, Boileau, Catherine, Kathiresan, Sekar

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Implementation of Flag, Identify, Network, Deliver (FIND FH) Machine Learning Algorithm: A Quality Improvement Initiative to Perform Targeted Screening for Familial Hypercholestero... von Sheth, Samip, Lee, Paul, Bajaj, Archna, Cuchel, Marina, DrNP, Jihane Hajj, Soffer, Daniel, Webb, Gayley, Hossain, Erik, Borovskiy, Yulia, Risman, Marjorie, Myers, Kelly, Wilemon, Katherine, Rader, Dan, Jacoby, Douglas

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Abstract 17566: Prevalence of Lipoprotein(a) Testing Among Patients With CAD: A 10-year Retrospective Analysis at The University of Pennsylvania Health Systems von Parvathinathan, Lakshmi, Risman, Marjorie, Alsattari, Ahmad, Rader, Daniel J, Bajaj, Archna

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Real-world Experience of Inclisiran at the University of Pennsylvania Health Systems von Risman, Marjorie, Bajaj, Archna, Tobin, Robert, Wei, Nicole

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Abstract P109: Hypertension in a Large Cohort of Patients With Lipoprotein(a) at a Tertiary Academic Center von Sheth, Samip, Risman, Marjorie, Rader, Daniel, Jacoby, Douglas

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High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease von Agarwala, Anandita P, Rodrigues, Amrith, Risman, Marjorie, McCoy, Mary, Trindade, Kevin, Qu, Liming, Cuchel, Marina, Billheimer, Jeffrey, Rader, Daniel J

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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection von Painter, Mark M., Johnston, Timothy S., Lundgreen, Kendall A., Santos, Jefferson J. S., Qin, Juliana S., Goel, Rishi R., Apostolidis, Sokratis A., Mathew, Divij, Fulmer, Bria, Williams, Justine C., McKeague, Michelle L., Pattekar, Ajinkya, Goode, Ahmad, Nasta, Sean, Baxter, Amy E., Giles, Josephine R., Skelly, Ashwin N., Felley, Laura E., McLaughlin, Maura, Weaver, Joellen, Kuthuru, Oliva, Dougherty, Jeanette, Adamski, Sharon, Long, Sherea, Kee, Macy, Clendenin, Cynthia, da Silva Antunes, Ricardo, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Huang, Alexander C., Rader, Daniel J., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John

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A Genome-First Approach to Identify Carriers of Familial Hypercholesterolemia Causing variants von Mami, Salma, Park, Joseph, Vedamurth, Deepak, Risman, Marjorie, Rader, Daniel J, Bajaj, Archna, Cuchel, Marina

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Trends in Lipoprotein(a) Testing at the University of Pennsylvania Health Systems from 2012-2021 von Bajaj, Archna, Parvathinathan, Lakshmi, Risman, Marjorie, Alsattari, Ahmad, Rader, Daniel J.

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Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores von Abramowitz, Sarah A, Boulier, Kristin, Keat, Karl, Cardone, Katie M, Shivakumar, Manu, DePaolo, John, Judy, Renae, Bermudez, Francisca, Mimouni, Nour, Neylan, Christopher, Kim, Dokyoon, Rader, Daniel J, Ritchie, Marylyn D, Voight, Benjamin F, Pasaniuc, Bogdan, Levin, Michael G, Damrauer, Scott M

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CT imaging-derived phenotypes for abdominal muscle and their association with age and sex in a medical biobank von Vu, Phuong T., Chahine, Chantal, Chatterjee, Neil, MacLean, Matthew T., Swago, Sophia, Bhattaru, Abhi, Thompson, Elizabeth W., Ikhlas, Anooshey, Oteng, Edith, Davidson, Lauren, Tran, Richard, Hazim, Mohamad, Raghupathy, Pavan, Verma, Anurag, Duda, Jeffrey, Gee, James, Luks, Valerie, Gershuni, Victoria, Wu, Gary, Rader, Daniel, Sagreiya, Hersh, Witschey, Walter R.

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Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis von Song, Isabel, Thompson, Elizabeth W., Verma, Anurag, MacLean, Matthew T., Duda, Jeffrey, Elahi, Ameena, Tran, Richard, Raghupathy, Pavan, Swago, Sophia, Hazim, Mohamad, Bhattaru, Abhijit, Schneider, Carolin, Vujkovic, Marijana, Torigian, Drew A., Kahn, Charles E., Gee, James C., Borthakur, Arijitt, Kripke, Colleen M., Carson, Christopher C., Carr, Rotonya, Jehangir, Qasim, Ko, Yi-An, Litt, Harold, Rosen, Mark, Mankoff, David A., Schnall, Mitchell D., Shou, Haochang, Chirinos, Julio, Damrauer, Scott M., Serper, Marina, Chen, Jinbo, Rader, Daniel J., Witschey, Walter R. T., Sagreiya, Hersh

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Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone von Dunn, Michael E., Kithcart, Aaron, Kim, Jee Hae, Ho, Andre Jo-Hao, Franklin, Matthew C., Romero Hernandez, Annabel, de Hoon, Jan, Botermans, Wouter, Meyer, Jonathan, Jin, Ximei, Zhang, Dongqin, Torello, Justin, Jasewicz, Daniel, Kamat, Vishal, Garnova, Elena, Liu, Nina, Rosconi, Michael, Pan, Hao, Karnik, Satyajit, Burczynski, Michael E., Zheng, Wenjun, Rafique, Ashique, Nielsen, Jonas B., De, Tanima, Verweij, Niek, Pandit, Anita, Locke, Adam, Chalasani, Naga, Melander, Olle, Schwantes-An, Tae-Hwi, Baras, Aris, Lotta, Luca A., Musser, Bret J., Mastaitis, Jason, Devalaraja-Narashimha, Kishor B., Rankin, Andrew J., Huang, Tammy, Herman, Gary, Olson, William, Murphy, Andrew J., Yancopoulos, George D., Olenchock, Benjamin A., Morton, Lori

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Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks von Yun, Jae-Seung, Jung, Sang-Hyuk, Lee, Su-Nam, Jung, Seung Min, Won, Hong-Hee, Kim, Dokyoon, Choi, Jin A

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Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways von Bajaj, Archna, Ihegword, Andrea, Qiu, Chengxiang, Small, Aeron M., Wei, Wei-Qi, Bastarache, Lisa, Feng, QiPing, Kember, Rachel L., Risman, Marjorie, Bloom, Roy D., Birtwell, David L., Williams, Heather, Shaffer, Christian M., Chen, Jinbo, Center, Regeneron Genetics, Denny, Joshua C., Rader, Daniel J., Stein, C. Michael, Damrauer, Scott M., Susztak, Katalin

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Multi-ethnic heterozygote frequencies of cancer susceptibility genes to inform counseling of reproductive risk von Powers, Jacquelyn, Wachtel, Heather, Desai, Heena, Verma, Anurag, Verma, Shefali S., Brock, Ashlei, DerOhannessian, Stephanie, Dudek, Scott, Dunn, Joseph, Drivas, Theodore, Haubein, Ned, Judy, Renae, Kloter, Ashley, Ko, Yi-An, Livingstone, Meghan, Morse, Colleen, Poindexter, Afiya, Risman, Marjorie, Tran, Teo, Weaver, JoEllen, Rader, Daniel J., Ritchie, Marylyn D., Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Pradhan, Manasi, Schleicher, Thomas D., Widom, Louis, Wolf, Sarah E., Ulloa, Ricardo H., Averitt, Amelia, Banerjee, Nilanjana, Cantor, Michael, Li, Dadong, Sharma, Deepika, MHI, Staples, Jeffrey, Bai, Xiaodong, Balasubramanian, Suganthi, Bao, Suying, Boutkov, Boris, Eom, Gisu, Hawes, Alicia, Khalid, Shareef, Krasheninina, Olga, Lanche, Rouel, Mansfield, Adam J., Maxwell, Evan K., O’Keeffe, Sean, Orelus, Max, B, Polanco, Tommy, Reid, Jeffrey G., Staples, Jeffrey C., Sun, Kathie, Abecasis, Goncalo, Backman, Joshua, Dobbyn, Lee, Revez Ferreira, Manuel Allen, Gillies, Christopher, Gurski, Lauren, Kang, Hyun Min, Kessler, Michael, Kosmicki, Jack, Li, Alexander, Lin, Nan, Liu, Daren, Marchini, Jonathan, Marcketta, Anthony, Stahl, Eli, Zhang, Blair, Ziyatdinov, Andrey, Ayer, Ariane, Guvenek, Aysegul, Hindy, George, Coppola, Giovanni, Freudenberg, Jan, Siminovitch, Katherine, Lotta, Luca A., Haas, Mary, Riaz, Moeen, Sosina, Olukayode, Nakka, Priyanka, Gelfman, Sahar, Rajagopal, Veera, Tzoneva, Gannie, Rodriguez-Flores, Juan, Chen, Esteban, Mighty, Jason, Mitnaul, Lyndon J., Nishtala, Nirupama, Rana, Nadia, Hernandez, Jaimee, Deubler, Andrew, Economides, Aris, Shuldiner, Alan, Maxwell, Kara N.

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Implementation of a Machine-Learning Algorithm in the Electronic Health Record for Targeted Screening for Familial Hypercholesterolemia: A Quality Improvement Study von Sheth, Samip, Lee, Paul, Bajaj, Archna, Cuchel, Marina, Hajj, Jihane, Soffer, Daniel E., Webb, Gayley, Hossain, Erik, Borovskiy, Yulia, Risman, Marjorie, Myers, Kelly D., Wilemon, Katherine A., Rader, Daniel J., Jacoby, Douglas

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HDL phospholipid content and cholesterol efflux capacity are reduced in patients with very high HDL-C and coronary disease von Agarwala, Anandita P., Rodrigues, Amrith, Risman, Marjorie, McCoy, Mary, Trindade, Kevin, Qu, Liming, Cuchel, Marina, Billheimer, Jeffrey, Rader, Daniel J.

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Large-scale identification of undiagnosed hepatic steatosis using natural language processing von Schneider, Carolin V., Li, Tang, Zhang, David, Mezina, Anya I., Rattan, Puru, Huang, Helen, Creasy, Kate Townsend, Scorletti, Eleonora, Zandvakili, Inuk, Vujkovic, Marijana, Hehl, Leonida, Fiksel, Jacob, Park, Joseph, Wangensteen, Kirk, Risman, Marjorie, Chang, Kyong-Mi, Serper, Marina, Carr, Rotonya M., Schneider, Kai Markus, Chen, Jinbo, Rader, Daniel J.

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