Rising incidence of early-onset colorectal cancer — a call to action von Akimoto, Naohiko, Ugai, Tomotaka, Zhong, Rong, Hamada, Tsuyoshi, Fujiyoshi, Kenji, Giannakis, Marios, Wu, Kana, Cao, Yin, Ng, Kimmie, Ogino, Shuji

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The landscape of cancer cell line metabolism von Li, Haoxin, Ning, Shaoyang, Ghandi, Mahmoud, Kryukov, Gregory V., Gopal, Shuba, Deik, Amy, Souza, Amanda, Pierce, Kerry, Keskula, Paula, Hernandez, Desiree, Ann, Julie, Shkoza, Dojna, Apfel, Verena, Zou, Yilong, Vazquez, Francisca, Barretina, Jordi, Pagliarini, Raymond A., Galli, Giorgio G., Root, David E., Hahn, William C., Tsherniak, Aviad, Giannakis, Marios, Schreiber, Stuart L., Clish, Clary B., Garraway, Levi A., Sellers, William R.

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Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma von Miao, Diana, Margolis, Claire A, Gao, Wenhua, Voss, Martin H, Li, Wei, Martini, Dylan J, Norton, Craig, Bossé, Dominick, Wankowicz, Stephanie M, Cullen, Dana, Horak, Christine, Wind-Rotolo, Megan, Tracy, Adam, Giannakis, Marios, Hodi, Frank Stephen, Drake, Charles G, Ball, Mark W, Allaf, Mohamad E, Snyder, Alexandra, Hellmann, Matthew D, Ho, Thai, Motzer, Robert J, Signoretti, Sabina, Kaelin, Jr, William G, Choueiri, Toni K, Van Allen, Eliezer M

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Metabolomic adaptations and correlates of survival to immune checkpoint blockade von Li, Haoxin, Bullock, Kevin, Gurjao, Carino, Braun, David, Shukla, Sachet A., Bossé, Dominick, Lalani, Aly-Khan A., Gopal, Shuba, Jin, Chelsea, Horak, Christine, Wind-Rotolo, Megan, Signoretti, Sabina, McDermott, David F., Freeman, Gordon J., Van Allen, Eliezer M., Schreiber, Stuart L., Stephen Hodi, F., Sellers, William R., Garraway, Levi A., Clish, Clary B., Choueiri, Toni K., Giannakis, Marios

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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy von Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias

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Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma von Giannakis, Marios, Mu, Xinmeng Jasmine, Shukla, Sachet A., Qian, Zhi Rong, Cohen, Ofir, Nishihara, Reiko, Bahl, Samira, Cao, Yin, Amin-Mansour, Ali, Yamauchi, Mai, Sukawa, Yasutaka, Stewart, Chip, Rosenberg, Mara, Mima, Kosuke, Inamura, Kentaro, Nosho, Katsuhiko, Nowak, Jonathan A., Lawrence, Michael S., Giovannucci, Edward L., Chan, Andrew T., Ng, Kimmie, Meyerhardt, Jeffrey A., Van Allen, Eliezer M., Getz, Gad, Gabriel, Stacey B., Lander, Eric S., Wu, Catherine J., Fuchs, Charles S., Ogino, Shuji, Garraway, Levi A.

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Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients von Tsai, Pei-Chen, Lee, Tsung-Hua, Kuo, Kun-Chi, Su, Fang-Yi, Lee, Tsung-Lu Michael, Marostica, Eliana, Ugai, Tomotaka, Zhao, Melissa, Lau, Mai Chan, Väyrynen, Juha P., Giannakis, Marios, Takashima, Yasutoshi, Kahaki, Seyed Mousavi, Wu, Kana, Song, Mingyang, Meyerhardt, Jeffrey A., Chan, Andrew T., Chiang, Jung-Hsien, Nowak, Jonathan, Ogino, Shuji, Yu, Kun-Hsing

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Precancer Atlas to Drive Precision Prevention Trials von Spira, Avrum, Yurgelun, Matthew B, Alexandrov, Ludmil, Rao, Anjana, Bejar, Rafael, Polyak, Kornelia, Giannakis, Marios, Shilatifard, Ali, Finn, Olivera J, Dhodapkar, Madhav, Kay, Neil E, Braggio, Esteban, Vilar, Eduardo, Mazzilli, Sarah A, Rebbeck, Timothy R, Garber, Judy E, Velculescu, Victor E, Disis, Mary L, Wallace, Douglas C, Lippman, Scott M

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RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition von Fang, Lishan, Ford-Roshon, Dane, Russo, Max, O’Brien, Casey, Xiong, Xiaozhe, Gurjao, Carino, Grandclaudon, Maximilien, Raghavan, Srivatsan, Corsello, Steven M., Carr, Steven A., Udeshi, Namrata D., Berstler, James, Sicinska, Ewa, Ng, Kimmie, Giannakis, Marios

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The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment von Väyrynen, Juha P, Haruki, Koichiro, Lau, Mai Chan, Väyrynen, Sara A, Zhong, Rong, Dias Costa, Andressa, Borowsky, Jennifer, Zhao, Melissa, Fujiyoshi, Kenji, Arima, Kota, Twombly, Tyler S, Kishikawa, Junko, Gu, Simeng, Aminmozaffari, Saina, Shi, Shanshan, Baba, Yoshifumi, Akimoto, Naohiko, Ugai, Tomotaka, Da Silva, Annacarolina, Guerriero, Jennifer L, Song, Mingyang, Wu, Kana, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A

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Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status von Hamada, Tsuyoshi, Cao, Yin, Qian, Zhi Rong, Masugi, Yohei, Nowak, Jonathan A, Yang, Juhong, Song, Mingyang, Mima, Kosuke, Kosumi, Keisuke, Liu, Li, Shi, Yan, da Silva, Annacarolina, Gu, Mancang, Li, Wanwan, Keum, NaNa, Zhang, Xuehong, Wu, Kana, Meyerhardt, Jeffrey A, Giovannucci, Edward L, Giannakis, Marios, Rodig, Scott J, Freeman, Gordon J, Nevo, Daniel, Wang, Molin, Chan, Andrew T, Fuchs, Charles S, Nishihara, Reiko, Ogino, Shuji

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The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis von Gibson, William J, Hoivik, Erling A, Halle, Mari K, Taylor-Weiner, Amaro, Cherniack, Andrew D, Berg, Anna, Holst, Frederik, Zack, Travis I, Werner, Henrica M J, Staby, Kjersti M, Rosenberg, Mara, Stefansson, Ingunn M, Kusonmano, Kanthida, Chevalier, Aaron, Mauland, Karen K, Trovik, Jone, Krakstad, Camilla, Giannakis, Marios, Hodis, Eran, Woie, Kathrine, Bjorge, Line, Vintermyr, Olav K, Wala, Jeremiah A, Lawrence, Michael S, Getz, Gad, Carter, Scott L, Beroukhim, Rameen, Salvesen, Helga B

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Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy von Hinze, Laura, Labrosse, Roxane, Degar, James, Han, Teng, Schatoff, Emma M, Schreek, Sabine, Karim, Salmaan, McGuckin, Connor, Sacher, Joshua R, Wagner, Florence, Stanulla, Martin, Yuan, Chen, Sicinska, Ewa, Giannakis, Marios, Ng, Kimmie, Dow, Lukas E, Gutierrez, Alejandro

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Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor von Zhang, Xiaoyang, Choi, Peter S, Francis, Joshua M, Gao, Galen F, Campbell, Joshua D, Ramachandran, Aruna, Mitsuishi, Yoichiro, Ha, Gavin, Shih, Juliann, Vazquez, Francisca, Tsherniak, Aviad, Taylor, Alison M, Zhou, Jin, Wu, Zhong, Berger, Ashton C, Giannakis, Marios, Hahn, William C, Cherniack, Andrew D, Meyerson, Matthew

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Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system von Spisak, Sandor, Chen, David, Likasitwatanakul, Pornlada, Doan, Paul, Li, Zhixin, Bala, Pratyusha, Vizkeleti, Laura, Tisza, Viktoria, De Silva, Pushpamali, Giannakis, Marios, Wolpin, Brian, Qi, Jun, Sethi, Nilay S.

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Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections von Väyrynen, Juha P, Lau, Mai Chan, Haruki, Koichiro, Väyrynen, Sara A, Dias Costa, Andressa, Borowsky, Jennifer, Zhao, Melissa, Fujiyoshi, Kenji, Arima, Kota, Twombly, Tyler S, Kishikawa, Junko, Gu, Simeng, Aminmozaffari, Saina, Shi, Shanshan, Baba, Yoshifumi, Akimoto, Naohiko, Ugai, Tomotaka, Da Silva, Annacarolina, Song, Mingyang, Wu, Kana, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A

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The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine von Garofalo, Andrea, Sholl, Lynette, Reardon, Brendan, Taylor-Weiner, Amaro, Amin-Mansour, Ali, Miao, Diana, Liu, David, Oliver, Nelly, MacConaill, Laura, Ducar, Matthew, Rojas-Rudilla, Vanesa, Giannakis, Marios, Ghazani, Arezou, Gray, Stacy, Janne, Pasi, Garber, Judy, Joffe, Steve, Lindeman, Neal, Wagle, Nikhil, Garraway, Levi A, Van Allen, Eliezer M

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Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status von Hamada, Tsuyoshi, Zhang, Xuehong, Mima, Kosuke, Bullman, Susan, Sukawa, Yasutaka, Nowak, Jonathan A, Kosumi, Keisuke, Masugi, Yohei, Twombly, Tyler S, Cao, Yin, Song, Mingyang, Liu, Li, da Silva, Annacarolina, Shi, Yan, Gu, Mancang, Li, Wanwan, Koh, Hideo, Nosho, Katsuhiko, Inamura, Kentaro, Keum, NaNa, Wu, Kana, Meyerhardt, Jeffrey A, Kostic, Aleksandar D, Huttenhower, Curtis, Garrett, Wendy S, Meyerson, Matthew, Giovannucci, Edward L, Chan, Andrew T, Fuchs, Charles S, Nishihara, Reiko, Giannakis, Marios, Ogino, Shuji

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Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer von Ugai, Tomotaka, Väyrynen, Juha P., Lau, Mai Chan, Borowsky, Jennifer, Akimoto, Naohiko, Väyrynen, Sara A., Zhao, Melissa, Zhong, Rong, Haruki, Koichiro, Dias Costa, Andressa, Fujiyoshi, Kenji, Arima, Kota, Wu, Kana, Chan, Andrew T., Cao, Yin, Song, Mingyang, Fuchs, Charles S., Wang, Molin, Lennerz, Jochen K., Ng, Kimmie, Meyerhardt, Jeffrey A., Giannakis, Marios, Nowak, Jonathan A., Ogino, Shuji

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Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location von Mima, Kosuke, Cao, Yin, Chan, Andrew T, Qian, Zhi Rong, Nowak, Jonathan A, Masugi, Yohei, Shi, Yan, Song, Mingyang, da Silva, Annacarolina, Gu, Mancang, Li, Wanwan, Hamada, Tsuyoshi, Kosumi, Keisuke, Hanyuda, Akiko, Liu, Li, Kostic, Aleksandar D, Giannakis, Marios, Bullman, Susan, Brennan, Caitlin A, Milner, Danny A, Baba, Hideo, Garraway, Levi A, Meyerhardt, Jeffrey A, Garrett, Wendy S, Huttenhower, Curtis, Meyerson, Matthew, Giovannucci, Edward L, Fuchs, Charles S, Nishihara, Reiko, Ogino, Shuji

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