fMRI study of the role of glutamate NMDA receptor in the olfactory processing in monkeys von Zhao, Fuqiang, Holahan, Marie A, Wang, Xiaohai, Uslaner, Jason M, Houghton, Andrea K, Evelhoch, Jeffrey L, Winkelmann, Christopher T, Hines, Catherine D G

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Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose von Ballard, Jeanine E., Pall, Parul S., Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Zhou, Xiaoping, Jochnowitz, Nina, Kraus, Richard L., Klein, Rebecca M., Henze, Darrell A., Houghton, Andrea K., Burgey, Christopher S., Gibson, Christopher, Struyk, Arie

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Robust arterial spin labeling MRI measurement of pharmacologically induced perfusion change in rat kidneys von Zhao, Fuqiang, Zhou, Xiaoyan, Messina, Eric, Hu, Lufei, Holahan, Marie A., Swaminath, Gayathri, Hines, Catherine D. G.

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Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate von Ballard, Jeanine E., Pall, Parul, Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Kraus, Richard, Li, Yuxing, Henze, Darrell, Houghton, Andrea, Burgey, Christopher S., Gibson, Christopher

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Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors von Zhu, Hong, Young, Mary B., Nantermet, Philippe G., Graham, Samuel L., Colussi, Dennis, Lai, Ming-Tain, Pietrak, Beth, Price, Eric A., Sankaranarayanan, Sethu, Shi, Xiao-ping, Tugusheva, Katherine, Holahan, Marie A., Michener, Maria S., Cook, Jacquelynn J., Simon, Adam, Hazuda, Daria J., Vacca, Joseph P., Rajapakse, Hemaka A.

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Functional imaging of olfaction by CBV fMRI in monkeys: Insight into the role of olfactory bulb in habituation von Zhao, Fuqiang, Holahan, Marie A., Houghton, Andrea K., Hargreaves, Richard, Evelhoch, Jeffrey L., Winkelmann, Christopher T., Williams, Donald S.

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Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements von Gilberto, David B, Michener, Maria S, Smith, Brad E, Szczerba, Peter J, Holahan, Marie A, Gray, Tasha L, Motzel, Sherri L

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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid... von Cook, Jacquelynn J, Wildsmith, Kristin R, Gilberto, David B, Holahan, Marie A, Kinney, Gene G, Mathers, Parker D, Michener, Maria S, Price, Eric A, Shearman, Mark S, Simon, Adam J, Wang, Jennifer X, Wu, Guoxin, Yarasheski, Kevin E, Bateman, Randall J

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman prim... von Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J

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Preclinical evaluation of [11C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone von Bennacef, Idriss, Rubins, Daniel, Riffel, Kerry, Williams, Mangay, Posavec, Diane J., Holahan, Marie A., Purcell, Mona L., Haley, Hyking D., Wolf, Mary, Stachel, Shawn J., Lubbers, Laura S., Wesolowski, Gregg A., Duong, Le T., Hamill, Terence G., Evelhoch, Jeffrey L., Hostetler, Eric D.

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Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs von Hutchinson, John H, Cook, Jacquelynn J, Brashear, Karen M, Breslin, Michael J, Glass, Joan D, Gould, Robert J, Halczenko, Wasyl, Holahan, Marie A, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Hartman, George D

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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240 von Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Hyking, Haley D, Holahan, Marie A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Reynders, Tom, Abbas, Walji, Hostetler, Eric D, Evelhoch, Jeffrey

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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240 von Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Haley, Hyking D, Marie, Holahan A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, David, Schenk J, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Tom, Reynders, Abbas, Walji, Eric, Hostetler D, Evelhoch, Jeffrey

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Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists von Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wai, Jenny M. C., DiPardo, Robert M., Murphy, Kathy L., Ransom, Richard W., Harrell, C. Meacham, Reiss, Duane R., Holahan, Marie A., Cook, Jacquelynn, Hess, J. Fred, Sain, Nova, Urban, Mark O., Tang, Cuyue, Prueksaritanont, Thomayant, Pettibone, Douglas J., Bock, Mark G.

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy von Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M., Trujillo, Maria, Trotter, Dinko Gonzalez, Feng, Danqing, Xu, Shiyao, Eiermann, George, Holahan, Marie A., Rubins, Daniel, Conarello, Stacey, Niu, Xiaoda, Souza, Sandra C., Miller, Corin, Liu, Jinqi, Lu, Ku, Feng, Wen, Li, Ying, Painter, Ronald E., Milligan, James A., He, Huaibing, Liu, Franklin, Ogawa, Aimie, Wisniewski, Douglas, Rohm, Rory J., Wang, Liyang, Bunzel, Michelle, Qian, Ying, Zhu, Wei, Wang, Hongwu, Bennet, Bindu, Scheuch, Lisa LaFranco, Fernandez, Guillermo E., Li, Cai, Klimas, Michael, Zhou, Gaochao, van Heek, Margaret, Biftu, Tesfaye, Weber, Ann, Kelley, David E., Thornberry, Nancy, Erion, Mark D., Kemp, Daniel M., Sebhat, Iyassu K.

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Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position von Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P

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9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors von Stauffer, Kenneth J, Williams, Peter D, Selnick, Harold G, Nantermet, Philippe G, Newton, Christina L, Homnick, Carl F, Zrada, Matthew M, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Pietrak, Beth L, Lyle, Elizabeth A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Wallace, Audrey A, Sitko, Gary R, Cook, Jacquelyn J, Holahan, Marie A, Stranieri-Michener, Maria, Leonard, Yvonne M, Lynch, Joseph J, McMasters, Daniel R, Yan, Youwei

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Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing von Nantermet, Philippe G., Rajapakse, Hemaka A., Stanton, Mathew G., Stauffer, Shaun R., Barrow, James C., Gregro, Allison R., Moore, Keith P., Steinbeiser, Melissa A., Swestock, John, Selnick, Harold G., Graham, Samuel L., McGaughey, Georgia B., Colussi, Dennis, Lai, Ming‐Tain, Sankaranarayanan, Sethu, Simon, Adam J., Munshi, Sanjeev, Cook, Jacquelynn J., Holahan, Marie A., Michener, Maria S., Vacca, Joseph P.

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α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists von WOOD, Michael R, SCHIRRIPA, Kathy M, CHANG, Raymond S. L, HOLAHAN, Marie A, COOK, Jacquelynn J, LEMAIRE, Wei, MOSSER, Scott D, BEDNAR, Rodney A, CUYUE TANG, PRUEKSARITANONT, Thomayant, WALLACE, Audrey A, QIN MEI, KIM, June J, JIAN YU, BOHN, Dennis L, CLAYTON, Frank C, ADARAYN, Emily D, SITKO, Gary R, LEONARD, Yvonne M, FREIDINGER, Roger M, PETTIBONE, Douglas J, BOCK, Mark G, KUDUK, Scott D, CHANG, Ronald K, DI MARCO, Christina N, DIPARDO, Robert M, WAN, Bang-Lin, MURPHY, Kathy L, RANSOM, Richard W

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Demonstration of enhanced endogenous fibrinolysis in thrombin activatable fibrinolysis inhibitor-deficient mice von Mao, Shi-Shan, Holahan, Marie A, Bailey, Carolyn, Wu, Guoxin, Colussi, Dennis, Carroll, Steven S, Cook, Jacquelynn J

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