Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS von Schneider, Rebekka K., Ademà, Vera, Heckl, Dirk, Järås, Marcus, Mallo, Mar, Lord, Allegra M., Chu, Lisa P., McConkey, Marie E., Kramann, Rafael, Mullally, Ann, Bejar, Rafael, Solé, Francesc, Ebert, Benjamin L.

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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease von Jaiswal, Siddhartha, Natarajan, Pradeep, Silver, Alexander J, Gibson, Christopher J, Bick, Alexander G, Shvartz, Eugenia, McConkey, Marie, Gupta, Namrata, Gabriel, Stacey, Ardissino, Diego, Baber, Usman, Mehran, Roxana, Fuster, Valentin, Danesh, John, Frossard, Philippe, Saleheen, Danish, Melander, Olle, Sukhova, Galina K, Neuberg, Donna, Libby, Peter, Kathiresan, Sekar, Ebert, Benjamin L

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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing von Heckl, Dirk, Kowalczyk, Monika S, Yudovich, David, Belizaire, Roger, Puram, Rishi V, McConkey, Marie E, Thielke, Anne, Aster, Jon C, Regev, Aviv, Ebert, Benjamin L

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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells von Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L

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Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms von Wolach, O, Sellar, RS, Martinod, K, Cherpokova, D, McConkey, M, Chappell, RJ, Silver, AJ, Adams, D, Castellano, CA, Schneider, RK, Padera, RF, DeAngelo, DJ, Wadleigh, M, Steensma, DP, Galinsky, I, Stone, RM, Genovese, G, McCarroll, SA, Iliadou, B, Hultman, C, Neuberg, D, Mullally, A, Wagner, DD, Ebert, BL

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SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia von Mar, Brenton G., Chu, S. Haihua, Kahn, Josephine D., Krivtsov, Andrei V., Koche, Richard, Castellano, Cecilia A., Kotlier, Jacob L., Zon, Rebecca L., McConkey, Marie E., Chabon, Jonathan, Chappell, Ryan, Grauman, Peter V., Hsieh, James J., Armstrong, Scott A., Ebert, Benjamin L.

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Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation von Obeng, Esther A, Chappell, Ryan J, Seiler, Michael, Chen, Michelle C, Campagna, Dean R, Schmidt, Paul J, Schneider, Rebekka K, Lord, Allegra M, Wang, Lili, Gambe, Rutendo G, McConkey, Marie E, Ali, Abdullah M, Raza, Azra, Yu, Lihua, Buonamici, Silvia, Smith, Peter G, Mullally, Ann, Wu, Catherine J, Fleming, Mark D, Ebert, Benjamin L

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Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis von Novershtern, Noa, Subramanian, Aravind, Lawton, Lee N., Mak, Raymond H., Haining, W. Nicholas, McConkey, Marie E., Habib, Naomi, Yosef, Nir, Chang, Cindy Y., Shay, Tal, Frampton, Garrett M., Drake, Adam C.B., Leskov, Ilya, Nilsson, Bjorn, Preffer, Fred, Dombkowski, David, Evans, John W., Liefeld, Ted, Smutko, John S., Chen, Jianzhu, Friedman, Nir, Young, Richard A., Golub, Todd R., Regev, Aviv, Ebert, Benjamin L.

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Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms von Sperling, Adam S., Guerra, Veronica A., Kennedy, James A., Yan, Yuanqing, Hsu, Joanne I., Wang, Feng, Nguyen, Andrew T., Miller, Peter G., McConkey, Marie E., Quevedo Barrios, Vanessa A., Furudate, Ken, Zhang, Linda, Kanagal-Shamanna, Rashmi, Zhang, Jianhua, Little, Latasha, Gumbs, Curtis, Daver, Naval, DiNardo, Courtney D., Kadia, Tapan, Ravandi, Farhad, Kantarjian, Hagop, Garcia-Manero, Guillermo, Futreal, P. Andrew, Ebert, Benjamin L., Takahashi, Koichi

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TET2-mutant clonal hematopoiesis and risk of gout von Agrawal, Mridul, Niroula, Abhishek, Cunin, Pierre, McConkey, Marie, Shkolnik, Veronica, Kim, Peter G., Wong, Waihay J., Weeks, Lachelle D., Lin, Amy E., Miller, Peter G., Gibson, Christopher J., Sekar, Aswin, Schaefer, Inga-Marie, Neuberg, Donna, Stone, Richard M., Bick, Alexander G., Uddin, Md Mesbah, Griffin, Gabriel K., Jaiswal, Siddhartha, Natarajan, Pradeep, Nigrovic, Peter A., Rao, Deepak A., Ebert, Benjamin L.

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PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells von Kahn, Josephine D., Miller, Peter G., Silver, Alexander J., Sellar, Rob S., Bhatt, Shruti, Gibson, Christopher, McConkey, Marie, Adams, Dylan, Mar, Brenton, Mertins, Philipp, Fereshetian, Shaunt, Krug, Karsten, Zhu, Haoling, Letai, Anthony, Carr, Steven A., Doench, John, Jaiswal, Siddhartha, Ebert, Benjamin L.

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Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations von Ajore, Ram, Raiser, David, McConkey, Marie, Jöud, Magnus, Boidol, Bernd, Mar, Brenton, Saksena, Gordon, Weinstock, David M, Armstrong, Scott, Ellis, Steven R, Ebert, Benjamin L, Nilsson, Björn

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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis von Kim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E., Slabicki, Mikolaj, Kemp, John P., Bick, Alexander, Gibson, Christopher J., Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J., Wong, Waihay J., Cohen, Drew N., Uddin, Md Mesbah, Shin, Wesley J., Pirruccello, James, Tsai, Jonathan M., Agrawal, Mridul, Kiel, Douglas P., Bouxsein, Mary L., Richards, J. Brent, Evans, David M., Wein, Marc N., Charles, Julia F., Jaiswal, Siddhartha, Natarajan, Pradeep, Ebert, Benjamin L.

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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML von Puram, Rishi V., Kowalczyk, Monika S., de Boer, Carl G., Schneider, Rebekka K., Miller, Peter G., McConkey, Marie, Tothova, Zuzana, Tejero, Héctor, Heckl, Dirk, Järås, Marcus, Chen, Michelle C., Li, Hubo, Tamayo, Alfred, Cowley, Glenn S., Rozenblatt-Rosen, Orit, Al-Shahrour, Fatima, Regev, Aviv, Ebert, Benjamin L.

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In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling von Miller, Peter G., Al-Shahrour, Fatima, Hartwell, Kimberly A., Chu, Lisa P., Järås, Marcus, Puram, Rishi V., Puissant, Alexandre, Callahan, Kevin P., Ashton, John, McConkey, Marie E., Poveromo, Luke P., Cowley, Glenn S., Kharas, Michael G., Labelle, Myriam, Shterental, Sebastian, Fujisaki, Joji, Silberstein, Lev, Alexe, Gabriela, Al-Hajj, Muhammad A., Shelton, Christopher A., Armstrong, Scott A., Root, David E., Scadden, David T., Hynes, Richard O., Mukherjee, Siddhartha, Stegmaier, Kimberly, Jordan, Craig T., Ebert, Benjamin L.

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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia von Järås, Marcus, Miller, Peter G, Chu, Lisa P, Puram, Rishi V, Fink, Emma C, Schneider, Rebekka K, Al-Shahrour, Fatima, Peña, Pablo, Breyfogle, L Jordan, Hartwell, Kimberly A, McConkey, Marie E, Cowley, Glenn S, Root, David E, Kharas, Michael G, Mullally, Ann, Ebert, Benjamin L

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EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression von Renneville, Aline, Van Galen, Peter, Canver, Matthew C., McConkey, Marie, Krill-Burger, John M., Dorfman, David M., Holson, Edward B., Bernstein, Bradley E., Orkin, Stuart H., Bauer, Daniel E., Ebert, Benjamin L.

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Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies von Renneville, Aline, Gasser, Jessica A, Grinshpun, Daniel E, Jean Beltran, Pierre M, Udeshi, Namrata D, Matyskiela, Mary E, Clayton, Thomas, McConkey, Marie, Viswanathan, Kaushik, Tepper, Alexander, Guirguis, Andrew A, Sellar, Rob S, Cotteret, Sophie, Marzac, Christophe, Saada, Véronique, De Botton, Stéphane, Kiladjian, Jean-Jacques, Cayuela, Jean-Michel, Rolfe, Mark, Chamberlain, Philip P, Carr, Steven A, Ebert, Benjamin L

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Regulation of Monoterpene Accumulation in Leaves of Peppermint von Gershenzon, Jonathan, Marie E. Mc Conkey, Croteau, Rodney B.

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Loss-of-Function Mutations in Dnmt3a and Tet2 Lead to Accelerated Atherosclerosis and Convergent Macrophage Phenotypes in Mice von Rauch, Philipp J., Silver, Alexander J., Gopakumar, Jk, McConkey, Marie, Sinha, Eti, Fefer, Maia, Shvartz, Eugenia, Sukhova, Galina, Libby, Peter, Ebert, Benjamin L., Jaiswal, Siddhartha

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