1O Clinical outcomes in post-operative ctDNA-positive muscle-invasive urothelial carcinoma (MIUC) patients after atezolizumab adjuvant therapy von Powles, T.B., Assaf, Z.J., Davarpanah, N., Hussain, M., Oudard, S., Gschwend, J.E., Albers, P., Castellano, D., Nishiyama, H., Daneshmand, S., Grivas, P., Sharma, S., Sethi, H., Aleshin, A., Zhang, J., Degaonkar, V., Bais, C., Carter, C.A., Bellmunt, J., Mariathasan, S.

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Biological features and clinical outcomes in atezolizumab (atezo)-treated patients (pts) with metastatic urothelial cancer (mUC) of the upper vs lower urinary tract (UTUC vs LTUC) von Galsky, M.D., Banchereau, R., Kadel, E.E., Ramirez-Montagut, T., Mariathasan, S., Thåström, A., Rosenberg, J., Powles, T., van der Heijden, M.S., Necchi, A.

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The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma von Munugalavadla, V, Mariathasan, S, Slaga, D, Du, C, Berry, L, Del Rosario, G, Yan, Y, Boe, M, Sun, L, Friedman, L S, Chesi, M, Leif Bergsagel, P, Ebens, A

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Atezolizumab monotherapy for metastatic urothelial carcinoma: final analysis from the phase II IMvigor210 trial von Rosenberg, J.E., Galsky, M.D., Powles, T., Petrylak, D.P., Bellmunt, J., Loriot, Y., Necchi, A., Hoffman-Censits, J., Perez-Gracia, J.L., van der Heijden, M.S., Dreicer, R., Durán, I., Castellano, D., Drakaki, A., Retz, M., Sridhar, S.S., Grivas, P., Yu, E.Y., O’Donnell, P.H., Burris, H.A., Mariathasan, S., Shi, Y., Goluboff, E., Bajorin, D.

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21LBA Atezolizumab in patients (pts) with locally-advanced or metastatic urothelial carcinoma (mUC): Results from a pivotal multicenter phase II study (IMvigor 210) von Rosenberg, J, Petrylak, D, Abidoye, O, Van der Heijden, M.S, Hofman-Censits, J, Necchi, A, O'Donnell, P.H, Balmanoukian, A, Loriot, Y, Retz, M, Perez-Gracia, J.L, Dawson, N.A, Balar, A, Galsky, M.D, Fleming, M.T, Powles, T, Cui, N, Mariathasan, S, Fine, G.D, Dreicer, R

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Markedly Impaired Humoral Immune Response in Mice Deficient in Complement Receptors 1 and 2 von Molina, Hector, Holers, V. Michael, Li, Bin, Fang, Yi-Fu, Mariathasan, Sanjeev, Goellner, Joseph, Strauss-Schoenberger, Jena, Karr, Robert W., Chaplin, David D.

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Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection von Mariathasan, Sanjeev, Zakarian, Arsen, Bouchard, Denis, Michie, Alison M, Zuniga-Pflucker, Juan Carlos, Ohashi, Pamela S

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Affinity maturation without germinal centres in lymphotoxin-α-deficient mice von Matsumoto, Mitsuru, Lo, Stanley F., Carruthers, Cynthia J. L., Min, Jingjuan, Mariathasan, Sanjeev, Huang, Guangming, Plas, David R., Martin, Steven M., Geha, Raif S., Nahm, Moon H., Chaplin, David D.

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Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes von Danska, Jayne S., Holland, Dianne P., Mariathasan, Sanjeev, Williams, Kelly M., Guidos, Cynthia J.

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Cryopyrin activates the inflammasome in response to toxins and ATP von Mariathasan, Sanjeev, Weiss, David S., Newton, Kim, McBride, Jacqueline, O'Rourke, Karen, Roose-Girma, Meron, Lee, Wyne P., Weinrauch, Yvette, Monack, Denise M., Dixit, Vishva M.

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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates von Staben, Leanna R., Koenig, Stefan G., Lehar, Sophie M., Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Linghu, Xin, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf von Mariathasan, Sanjeev, Newton, Kim, Monack, Denise M., Vucic, Domagoj, French, Dorothy M., Lee, Wyne P., Roose-Girma, Meron, Erickson, Sharon, Dixit, Vishva M.

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Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis von Mariathasan, Sanjeev, Weiss, David S, Dixit, Vishva M, Monack, Denise M

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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection von Zamboni, Dario S, Kobayashi, Koichi S, Kohlsdorf, Tiana, Ogura, Yasunori, Long, E Michelle, Vance, Russell E, Kuida, Keisuke, Mariathasan, Sanjeev, Dixit, Vishva M, Flavell, Richard A, Dietrich, William F, Roy, Craig R

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716TiP IMvigor011: A global, double-blind, randomised phase III study of atezolizumab (atezo; anti–PD-L1) vs placebo (pbo) as adjuvant therapy in patients (pts) with high-risk musc... von Powles, T.B., Gschwend, J.E., Bracarda, S., Castellano, D., Gross-Goupil, M., Bjerggaard Jensen, J., Kann, A., Nishiyama, H., Makaroff, L., Lassidi, H., Mariathasan, S., Zhang, J., Degaonkar, V., Bellmunt, J.

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658MO Cisplatin (cis)-related immunomodulation and efficacy with atezolizumab (atezo) + cis- vs carboplatin (carbo)-based chemotherapy (chemo) in metastatic urothelial cancer (mUC) von Galsky, M.D., Guan, X., Banchereau, R., Wang, L., Zhu, J., Yu, H., Rishipathak, D., Hajaj, E., Herbst, R.H., Davis, I.D., Grande, E., Bamias, A., De Santis, M., Arranz, J.Á., Kikuchi, E., Zhang, J., Lee, C., Shen, X., Black, P.C., Mariathasan, S.

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Kocuria marina BS-15 a biosurfactant producing halophilic bacteria isolated from solar salt works in India von Sarafin, Yesurethinam, Donio, Mariathasan Birdilla Selva, Velmurugan, Subramanian, Michaelbabu, Mariavincent, Citarasu, Thavasimuthu

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1735O PD-L1 expression on immune cells by SP142 co-localises with dendritic cells and is associated with improved overall survival (OS) with atezolizumab in patients with untreated... von Grande Pulido, E., Galsky, M.D., Van Elzen, R., Banchereau, R., Peterson, M., Sedano, C., Koeppen, H., Li, H., Bamias, A., Arranz Arija, J.A., Kikuchi, E., De Santis, M., Davis, I.D., Mellman, I., Oh, S., Williams, P., Bernhard, S., Lee, C.P., Kockx, M., Mariathasan, S.

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902PBiological features and clinical outcomes in atezolizumab (atezo)-treated patients (pts) with metastatic urothelial cancer (mUC) of the upper vs lower urinary tract (UTUC vs LT... von Galsky, M D, Banchereau, R, Kadel, E E, Ramirez-Montagut, T, Mariathasan, S, Thåström, A, Rosenberg, J, Powles, T, van der Heijden, M S, Necchi, A

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IMvigor130: Efficacy and safety from a phase III study of atezolizumab (atezo) as monotherapy or combined with platinum-based chemotherapy (PBC) vs placebo + PBC in previously untr... von Grande, E., Galsky, M., Arranz Arija, J.A., De Santis, M., Davis, I.D., De Giorgi, U.F.F., Mencinger, M., Kikuchi, E., Garcia del Muro, X., Gumus, M., Özgüroğlu, M., Rezazadeh Kalebasty, A., Park, S.H., Alekseev, B.Y., Schutz, F.A.B., Li, J.-R., Mecke, A., Mariathasan, S., Thastrom, A., Bamias, A.

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