Translating in vitro to in vivo and animal to human von Steger-Hartmann, Thomas, Raschke, Marian

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Rat pancreas tissue slices as in vitro model for studying drug-induced pancreatic toxicity von Hellmund, Maria, Raschke, Marian, Frisk, Anna-Lena

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Differentiation of Aneugens and Clastogens in the In Vitro Micronucleus Test by Kinetochore Scoring Using Automated Image Analysis von Wilde, Sabrina, Queisser, Nina, Holz, Christian, Raschke, Marian, Sutter, Andreas

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Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model von Hübner, Juliane, Raschke, Marian, Rütschle, Isabel, Gräßle, Sarah, Hasenberg, Tobias, Schirrmann, Kerstin, Lorenz, Alexandra, Schnurre, Susanne, Lauster, Roland, Maschmeyer, Ilka, Steger-Hartmann, Thomas, Marx, Uwe

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Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688 von Battista, Christina, Shoda, Lisl K.M., Watkins, Paul B., Groettrup‐Wolfers, Esther, Rottmann, Antje, Raschke, Marian, Generaux, Grant T.

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A tripartite mode of action approach for investigating the impact of aneugens on tubulin polymerization von Stock, Valerie, Sutter, Andreas, Raschke, Marian, Queisser, Nina, Gollapudi, B.

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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity von Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T‑Cell Immunity against Cancer von Mowat, Jeffrey, Carretero, Rafael, Leder, Gabriele, Aiguabella Font, Nuria, Neuhaus, Roland, Berndt, Sandra, Günther, Judith, Friberg, Anders, Schäfer, Martina, Briem, Hans, Raschke, Marian, Miyatake Ondozabal, Hideki, Buchmann, Bernd, Boemer, Ulf, Kreft, Bertolt, Hartung, Ingo V., Offringa, Rienk

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A microfluidic thyroid-liver platform to assess chemical safety in humans von Kuhnlenz, Julia, Karwelat, Diana, Steger-Hartmann, Thomas, Raschke, Marian, Bauer, Sophie, Vural, Ozlem, Marx, Uwe, Tinwell, Helen, Bars, Remi

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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase von Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus

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A Rodent Thyroid-Liver Chip to Capture Thyroid Toxicity on Organ Function Level von Karwelat, Diana, Kuhnlenz, Julia, Steger-Hartmann, Thomas, Bars, Remi, Tinwell, Helen, Marx, Uwe, Bauer, Sophie, Born, Oliver, Raschke, Marian

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New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Re... von Vakalopoulos, Alexandros, Wunder, Frank, Hartung, Ingo V., Redlich, Gorden, Jautelat, Rolf, Buchgraber, Philipp, Hassfeld, Jorma, Gromov, Alexey V., Lindner, Niels, Bierer, Donald, Gries, Jörg, Kroh, Walter, Paulsen, Holger, Mittendorf, Joachim, Lang, Dieter, Becker-Pelster, Eva, Brockschnieder, Damian, Geiss, Volker, Li, Volkhart, Straub, Alexander, Knorr, Andreas, Mondritzki, Thomas, Trübel, Hubert, Raschke, Marian, Schaefer, Martina, Thomas, Dirk, Sandner, Peter, Stasch, Johannes-Peter, Follmann, Markus

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Abstract LB-027: Evaluation of EGFR induced on-target and target-mediated adverse effects in a 3D human lung tumour/skin microphysiological co-culture system von Huebner, Juliane, Raschke, Marian, Schimek, Katharina, Ruetschle, Isabel, Graessle, Sarah, Schnurre, Susanne, Lauster, Roland, Maschmeyer, Ilka, Steger-Hartmann, Thomas, Marx, Uwe

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Fail Early, Fail Cheap: Project Termination During Lead Optimization Due to Mitochondrial Toxicity von Himmel, Herbert, Raschke, Marian, Siemeister, Gerhard, Baerfacker, Lars, Ruehl-Fehlert, Christine, Zierz, Rupprecht

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A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay von Igl, Bernd-Wolfgang, Dertinger, Stephen D., Dobrovolsky, Vasily N., Raschke, Marian, Sutter, Andreas, Vonk, Richardus

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Best practices for application of attachment cells to in vitro micronucleus assessment by flow cytometry von Bemis, Jeffrey C., Bryce, Steven M., Nern, Marlies, Raschke, Marian, Sutter, Andreas

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Comparison of the Mesoscale Discovery and Luminex multiplex platforms for measurement of urinary biomarkers in a cisplatin rat kidney injury model von Pavkovic, Mira, Riefke, Björn, Gutberlet, Katrin, Raschke, Marian, Ellinger-Ziegelbauer, Heidrun

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The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury von Ellinger-Ziegelbauer, Heidrun, Adler, Melanie, Amberg, Alexander, Brandenburg, Arnd, Callanan, John J., Connor, Susan, Fountoulakis, Michael, Gmuender, Hans, Gruhler, Albrecht, Hewitt, Philip, Hodson, Mark, Matheis, Katja A., McCarthy, Diane, Raschke, Marian, Riefke, Björn, Schmitt, Christina S., Sieber, Max, Sposny, Alexandra, Suter, Laura, Sweatman, Brian, Mally, Angela

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Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress von Raschke, Marian, Rowland, Ian R., Magee, Pamela J., Pool-Zobel, Beatrice L.

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Abstract 1163: Phosphoserine aminotransferase 1 (PSAT1) as a novel anti-tumor target in hepatocellular carcinoma von Ding, Zhaobing, Wee, Kenneth, Kim, Eung-Sam, Samanta, Animesh, Steckel, Michael, Raschke, Marian, Velan, Sendhil, Chang, Young-Tae, Haegebarth, Andrea, Ziegelbauer, Karl, Gruenewald, Sylvia, Han, Weiping

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