Gender Difference in sidE eFfects of ImmuNotherapy: a possible clue to optimize cancEr tReatment (G-DEFINER): study protocol of an observational prospective multicenter study von Miceli, Rosalba, Eriksson, Hanna, Lo Russo, Giuseppe, Alfieri, Salvatore, Moksnes Bjaanæs, Maria, Pietrantonio, Filippo, De Cecco, Loris, Prelaj, Arsela, Proto, Claudia, Franzén, Johan, McDonnell, Deirdre, Berenguer Pina, José Javier, Beninato, Teresa, Mazzeo, Laura, Giannatempo, Patrizia, Verzoni, Elena, Crown, John, Helland, Åslaug, Eustace, Alexander

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EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC von Zhang, Ruyang, Lai, Linjing, He, Jieyu, Chen, Chao, You, Dongfang, Duan, Weiwei, Dong, Xuesi, Zhu, Ying, Lin, Lijuan, Shen, Sipeng, Guo, Yichen, Su, Li, Shafer, Andrea, Moran, Sebastian, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Chen, Feng, Christiani, David C.

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Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients von Ji, Xinyu, Lin, Lijuan, Shen, Sipeng, Dong, Xuesi, Chen, Chao, Li, Yi, Zhu, Ying, Huang, Hui, Chen, Jiajin, Chen, Xin, Wei, Liangmin, He, Jieyu, Duan, Weiwei, Su, Li, Jiang, Yue, Fan, Juanjuan, Guan, Jinxing, You, Dongfang, Shafer, Andrea, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Zhang, Ruyang, Chen, Feng, Christiani, David C.

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SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic–smoking interaction analysis von Zhang, Ruyang, Lai, Linjing, Dong, Xuesi, He, Jieyu, You, Dongfang, Chen, Chao, Lin, Lijuan, Zhu, Ying, Huang, Hui, Shen, Sipeng, Wei, Liangmin, Chen, Xin, Guo, Yichen, Liu, Liya, Su, Li, Shafer, Andrea, Moran, Sebastian, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Chen, Feng, Christiani, David C.

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Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effe... von Zhang, Ruyang, Chen, Chao, Dong, Xuesi, Shen, Sipeng, Lai, Linjing, He, Jieyu, You, Dongfang, Lin, Lijuan, Zhu, Ying, Huang, Hui, Chen, Jiajin, Wei, Liangmin, Chen, Xin, Li, Yi, Guo, Yichen, Duan, Weiwei, Liu, Liya, Su, Li, Shafer, Andrea, Fleischer, Thomas, Moksnes Bjaanæs, Maria, Karlsson, Anna, Planck, Maria, Wang, Rui, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Chen, Feng, Christiani, David C.

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EMT network-based feature selection improves prognosis prediction in lung adenocarcinoma von Shao, Borong, Bjaanæs, Maria Moksnes, Helland, Åslaug, Schütte, Christof, Conrad, Tim

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Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors von Bjaanæs, Maria Moksnes, Nilsen, Gro, Halvorsen, Ann Rita, Russnes, Hege G., Solberg, Steinar, Jørgensen, Lars, Brustugun, Odd Terje, Lingjærde, Ole Christian, Helland, Åslaug

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Thoracic radiation in combination with erlotinib-results from a phase 2 randomized trial von Nymoen, Hanne Marte, Alver, Tine Norman, Horndalsveen, Henrik, Eide, Hanne Astrid, Bjaanæs, Maria Moksnes, Brustugun, Odd Terje, Grønberg, Bjørn Henning, Haakensen, Vilde Drageset, Helland, Åslaug

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NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma von Haakensen, Vilde Drageset, Nowak, Anna K, Ellingsen, Espen Basmo, Farooqi, Saima Jamil, Bjaanaes, Maria Moksnes, Horndalsveen, Henrik, Mcculloch, Tine, Grundberg, Oscar, Cedres, Susana M, Helland, Ãslaug

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Atezolizumab and stereotactic body radiotherapy in patients with advanced non‐small cell lung cancer: safety, clinical activity and ctDNA responses—the ComIT‐1 trial von Horndalsveen, Henrik, Alver, Tine Norman, Dalsgaard, Astrid Marie, Rogg, Lotte Victoria, Helbekkmo, Nina, Grønberg, Bjørn Henning, Halvorsen, Tarje Onsøien, Ramberg, Christina, Haakensen, Vilde Drageset, Öjlert, Åsa Kristina, Bjaanæs, Maria Moksnes, Helland, Åslaug

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Epigenome‐wide three‐way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early‐stage NSCLC von Ji, Xinyu, Lin, Lijuan, Fan, Juanjuan, Li, Yi, Wei, Yongyue, Shen, Sipeng, Su, Li, Shafer, Andrea, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Zhang, Ruyang, Chen, Feng, Christiani, David C.

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A trans‐omics assessment of gene–gene interaction in early‐stage NSCLC von Chen, Jiajin, Song, Yunjie, Li, Yi, Wei, Yongyue, Shen, Sipeng, Zhao, Yang, You, Dongfang, Su, Li, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Shen, Hongbing, Christiani, David C., Zhang, Ruyang, Chen, Feng

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Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer von Bjaanæs, Maria Moksnes, Sande, Erlend Peter Skaug, Loe, Øyvind, Ramberg, Christina, Næss, Tove Mette, Ottestad, Andreas, Rogg, Lotte V., Svestad, Jørund Graadal, Haakensen, Vilde Drageset

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Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis von Bjaanæs, Maria Moksnes, Fleischer, Thomas, Halvorsen, Ann Rita, Daunay, Antoine, Busato, Florence, Solberg, Steinar, Jørgensen, Lars, Kure, Elin, Edvardsen, Hege, Børresen-Dale, Anne-Lise, Brustugun, Odd Terje, Tost, Jörg, Kristensen, Vessela, Helland, Åslaug

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Unique microRNA‐profiles in EGFR‐mutated lung adenocarcinomas von Bjaanæs, Maria Moksnes, Halvorsen, Ann Rita, Solberg, Steinar, Jørgensen, Lars, Dragani, Tommaso A., Galvan, Antonella, Colombo, Francesca, Anderlini, Marco, Pastorino, Ugo, Kure, Elin, Børresen‐Dale, Anne‐Lise, Brustugun, Odd Terje, Helland, Åslaug

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DNA Methylation of LRRC3B : A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients von Guo, Yichen, Zhang, Ruyang, Shen, Sipeng, Wei, Yongyue, Salama, Sebastian Moran, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Su, Li, Zhu, Zhaozhong, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Christiani, David C

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Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma von Dong, Xuesi, Zhang, Ruyang, He, Jieyu, Lai, Linjing, Alolga, Raphael N, Shen, Sipeng, Zhu, Ying, You, Dongfang, Lin, Lijuan, Chen, Chao, Zhao, Yang, Duan, Weiwei, Su, Li, Shafer, Andrea, Salama, Moran, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Wang, Rui, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Chen, Feng, Christiani, David C

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Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients von Chen, Chao, Wei, Yongyue, Wei, Liangmin, Chen, Jiajin, Chen, Xin, Dong, Xuesi, He, Jieyu, Lin, Lijuan, Zhu, Ying, Huang, Hui, You, Dongfang, Lai, Linjing, Shen, Sipeng, Duan, Weiwei, Su, Li, Shafer, Andrea, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Wang, Rui, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Zhang, Ruyang, Chen, Feng, Christiani, David C

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The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes von Eide, Hanne A, Halvorsen, Ann Rita, Bjaanæs, Maria Moksnes, Piri, Hossein, Holm, Ruth, Solberg, Steinar, Jørgensen, Lars, Brustugun, Odd Terje, Kiserud, Cecilie Essholt, Helland, Åslaug

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A multi‐omic study reveals BTG2 as a reliable prognostic marker for early‐stage non‐small cell lung cancer von Shen, Sipeng, Zhang, Ruyang, Guo, Yichen, Loehrer, Elizabeth, Wei, Yongyue, Zhu, Ying, Yuan, Qianyu, Moran, Sebastian, Fleischer, Thomas, Bjaanæs, Maria M., Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Su, Li, Chen, Feng, Christiani, David C.

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