Predictive factors of sensitivity to elisidepsin, a novel Kahalalide F-derived marine compound von Serova, Maria, de Gramont, Armand, Bieche, Ivan, Riveiro, Maria Eugenia, Galmarini, Carlos Maria, Aracil, Miguel, Jimeno, José, Faivre, Sandrine, Raymond, Eric

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Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib von Serova, Maria, de Gramont, Armand, Tijeras-Raballand, Annemilaï, Dos Santos, Célia, Riveiro, Maria Eugenia, Slimane, Khemaies, Faivre, Sandrine, Raymond, Eric

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Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib von Serova, Maria, Tijeras-Raballand, Annemilaï, Dos Santos, Celia, Martinet, Matthieu, Neuzillet, Cindy, Lopez, Alfred, Mitchell, Dianne C, Bryan, Brad A, Gapihan, Guillaume, Janin, Anne, Bousquet, Guilhem, Riveiro, Maria Eugenia, Bieche, Ivan, Faivre, Sandrine, Raymond, Eric, de Gramont, Armand

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The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs von Boi, Michela, Gaudio, Eugenio, Bonetti, Paola, Kwee, Ivo, Bernasconi, Elena, Tarantelli, Chiara, Rinaldi, Andrea, Testoni, Monica, Cascione, Luciano, Ponzoni, Maurilio, Mensah, Afua Adjeiwaa, Stathis, Anastasios, Stussi, Georg, Riveiro, María Eugenia, Herait, Patrice, Inghirami, Giorgio, Cvitkovic, Esteban, Zucca, Emanuele, Bertoni, Francesco

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Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK‐8628 in malignant pleural mesothelioma xenografts von Vázquez, Ramiro, Licandro, Simonetta Andrea, Astorgues‐Xerri, Lucile, Lettera, Emanuele, Panini, Nicolò, Romano, Michela, Erba, Eugenio, Ubezio, Paolo, Bello, Ezia, Libener, Roberta, Orecchia, Sara, Grosso, Federica, Riveiro, María Eugenia, Cvitkovic, Esteban, Bekradda, Mohamed, D'Incalci, Maurizio, Frapolli, Roberta

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Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum von Eugenia Riveiro, Marı́a, Shayo, Carina, Monczor, Federico, Fernández, Natalia, Baldi, Alberto, De Kimpe, Norbert, Rossi, Javier, Debenedetti, Silvia, Davio, Carlos

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Abstract 1294: Dual targeting of PDK1 and Aurora A using first-in class OXID-pyridonyl compounds in preclinical models of Ewing sarcoma von Riveiro, Maria Eugenia, Rapposelli, Simona, Huguet, Samuel, Vazquez, Ramiro, Bekradda, Mohamed, Puricelli, Guido, Sestito, Simona, Madar, Olivier, Rezai, Keyvan

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Abstract 916: A novel LAP-IL2 fusion protein elicits efficacy as single agent in syngeneic renal and melanoma mouse models von Riveiro, Maria Eugenia, Frapolli, Roberta, Taraboletti, Giulia Taraboletti Giulia, Rezai, Keyvan, Meroni, Marina, Russo, Massimo, Borsotti, Patrizia, Schultz, Chris, Gould, David, Chernajovsky, Yuti

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Focus on the role of the CXCL12/CXCR4 chemokine axis in head and neck squamous cell carcinoma von Albert, Sébastien, Riveiro, Maria Eugenia, Halimi, Caroline, Hourseau, Muriel, Couvelard, Anne, Serova, Maria, Barry, Béatrix, Raymond, Eric, Faivre, Sandrine

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The BET Inhibitor OTX015 (MK-8628) Shows in Vivo Antitumor Activity in Combination with Additional Targeted Agents in Diffuse Large B-Cell Lymphoma (DLBCL) von Gaudio, Eugenio, Cascione, Luciano, Ponzoni, Maurilio, Tarantelli, Chiara, Bernasconi, Elena, Riveiro, Maria Eugenia, Cvitkovic, Esteban, Zucca, Emanuele, Bertoni, Francesco

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Abstract 4511: Pharmacokinetics of OTX015 in a phase Ib dose-finding study of patients with hematologic malignancies: Preliminary results of a population PK analysis von Odore, Elodie, Lokiec, Francois, Riveiro, Maria Eugenia, Bourdel, Fabrice, Kahatt, Carmen, Herait, Patrice, Cvitkovic, Esteban, Rezai, Keyvan

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Abstract 3530: Gene expression profile of OTX015, a BET bromodomain inhibitor, in preclinical models of non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) models von Riveiro, Maria Eugenia, Kwee, Ivo, Astorgues-Xerri, Lucile, Bekradda, Mohamed, Vazquez, Ramiro, Rinaldi, Andrea, Cvitkovic, Esteban, Bertoni, Francesco

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Abstract 2569: Development of potent dual PDK1/AurA kinase inhibitors for Ewing sarcoma therapy von Riveiro, Maria Eugenia, Huguet, Samuel, Vazquez, Ramiro, Frapolli, Roberta, Puricelli, Guido, Sestito, Simona, Madar, Olivier, Rezai, Keyvan, Garau, Gianpiero, Rapposelli, Simona

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Preclinical Evaluation of the BET-Bromodomain (BET-BRD) Inhibitor OTX015 in Leukemia Cell Lines Harboring the JAK2 V617F Mutation von Riveiro, Maria Eugenia, Astorgues-Xerri, Lucile, Canet-jourdan, Charlotte, Bekradda, Mohamed, Cvitkovic, Esteban, Herait, Patrice, Raymond, Eric

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Abstract A121: Preclinical evaluation of OTX015 a novel BET-BRD inhibitor across a panel of solid tumor cell lines of different lineages von Riveiro, Maria Eugenia, Astorgues-Xerri, Lucile, Odore, Elodie, Bekradda, Mohamed, Cvitkovic, Esteban, Noel, Kay, Raymond, Eric

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Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue von Albert, Sébastien, Hourseau, Muriel, Halimi, Caroline, Serova, Maria, Descatoire, Véronique, Barry, Béatrix, Couvelard, Anne, Riveiro, Maria Eugenia, Tijeras-Raballand, Annemilaï, de Gramont, Armand, Raymond, Eric, Faivre, Sandrine

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Total synthesis of naturally occurring 5,6,7- and 5,7,8-trioxygenated coumarins von Maes, Dominick, Riveiro, Maria Eugenia, Shayo, Carina, Davio, Carlos, Debenedetti, Silvia, De Kimpe, Norbert

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The BET-Bromodomain Inhibitor OTX015 Is Active As a Single Agent and in Combination with Other Targeted Drugs in Preclinical Models of Mantle Cell Lymphoma von Bernasconi, Elena, Tarantelli, Chiara, Gaudio, Eugenio, Kwee, Ivo, Rinaldi, Andrea, Cascione, Luciano, Stathis, Anastasios, Riveiro, Maria Eugenia, Zucca, Emanuele, Bertoni, Francesco

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BET Bromodomain Inhibitor OTX015 Affects the Expression of Micrornas Involved in the Pathogenesis of Diffuse Large B-Cell Lymphoma von Cascione, Luciano, Gaudio, Eugenio, Bernasconi, Elena, Tarantelli, Chiara, Rinaldi, Andrea, Testoni, Monica, Bomben, Riccardo, Gattei, Valter, Kwee, Ivo, Stathis, Anastasios, Riveiro, Maria Eugenia, Zucca, Emanuele, Bertoni, Francesco

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Bromodomain Inhibition By OTX015 Regulates c-MYC and HEXIM1 in a Panel of Human Acute Leukemia Cell Lines von Coudé, Marie-Magdelaine, Braun, Thorsten, Berrou, Jeannig, Dupont, Mélanie, Itzykson, Raphael, Masse, Aline, Raffoux, Emmanuel, Riveiro, Maria Eugenia, Herait, Patrice, Baruchel, Andre, Dombret, Hervé, Gardin, Claude

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