The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions von Tessmer, Ingrid, Margison, Geoffrey P

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Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O6-Alkylated Guanine Bases in DNA von Yaakub, Hanum, Howell, Anthony, Margison, Geoffrey P., Povey, Andrew C.

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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency von Sun, Guohui, Bai, Peiying, Fan, Tengjiao, Zhao, Lijiao, Zhong, Rugang, McElhinney, R. Stanley, McMurry, T. Brian H, Donnelly, Dorothy J, McCormick, Joan E, Kelly, Jane, Margison, Geoffrey P

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O⁶-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function von Ezerskyte, Monika, Paredes, João A., Malvezzi, Stefano, Burns, John A., Margison, Geoffrey P., Olsson, Magnus, Scicchitano, David A., Dreij, Kristian

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Randomized Trial of the Combination of Lomeguatrib and Temozolomide Compared With Temozolomide Alone in Chemotherapy Naive Patients With Metastatic Cutaneous Melanoma von RANSON, Malcolm, HERSEY, Peter, BAKA, Sofia, SEEBARAN, Augustus, SABHARWAL, Ami, WATSON, Amanda J, MARGISON, Geoffrey P, MIDDLETON, Mark R, THOMPSON, Damien, BEITH, Jane, MCARTHUR, Grant A, HAYDON, Andrew, DAVIS, Ian D, KEFFORD, Richard F, MORTIMER, Peter, HARRIS, Peter A

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Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway von Middleton, Mark R, Margison, Geoffrey P

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Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions von Wilkinson, Oliver J, Latypov, Vitaly, Tubbs, Julie L, Millington, Christopher L, Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J, Connolly, Bernard A, Grasby, Jane A, Masui, Ryoji, Hunter, Christopher A, Tainer, John A, Margison, Geoffrey P, Williams, David M

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Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O 6‑Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Pre... von Abdelhady, Rasha, Senthong, Pattama, Eyers, Claire E., Reamtong, Onrapak, Cowley, Elizabeth, Cannizzaro, Luca, Stimpson, Joanna, Cain, Kathleen, Wilkinson, Oliver J., Williams, Nicholas H., Barran, Perdita E., Margison, Geoffrey P., Williams, David M., Povey, Andrew C.

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Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI von Chinnasamy, Dhanalakshmi, Milsom, Michael D, Shaffer, James, Neuenfeldt, James, Shaaban, Aimen F, Margison, Geoffrey P, Fairbairn, Leslie J, Chinnasamy, Nachimuthu

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Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients von Agnihotri, Sameer, Gajadhar, Aaron S, Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L, Mischel, Paul S, Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L, Sarkaria, Jann N, Margison, Geoffrey P, Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit

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Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Pres... von Abdelhady, Rasha, Senthong, Pattama, Eyers, Claire E, Reamtong, Onrapak, Cowley, Elizabeth, Cannizzaro, Luca, Stimpson, Joanna, Cain, Kathleen, Wilkinson, Oliver J, Williams, Nicholas H, Barran, Perdita E, Margison, Geoffrey P, Williams, David M, Povey, Andrew C

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Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells von Zhang, Haihong, Mizumachi, Takatsugu, Carcel-Trullols, Jaime, Li, Liwen, Naito, Akihiro, Spencer, Horace J., Spring, Paul M., Smoller, Bruce R., Watson, Amanda J., Margison, Geoffrey P., Higuchi, Masahiro, Fan, Chun-Yang

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O 6 -methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function von Ezerskyte, Monika, Paredes, João A, Malvezzi, Stefano, Burns, John A, Margison, Geoffrey P, Olsson, Magnus, Scicchitano, David A, Dreij, Kristian

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A potential role of heat shock proteins and nicotinamide N‐methyl transferase in predicting response to radiation in bladder cancer von Kassem, Heba Sh, Sangar, Vijay, Cowan, Richard, Clarke, Noel, Margison, Geoffrey P.

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Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines von Latypov, Vitaly F., Tubbs, Julie L., Watson, Amanda J., Marriott, Andrew S., McGown, Gail, Thorncroft, Mary, Wilkinson, Oliver J., Senthong, Pattama, Butt, Amna, Arvai, Andrew S., Millington, Christopher L., Povey, Andrew C., Williams, David M., Santibanez-Koref, Mauro F., Tainer, John A., Margison, Geoffrey P.

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MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide von Erice, Oihane, Smith, Michael P, White, Rachel, Goicoechea, Ibai, Barriuso, Jorge, Jones, Chris, Margison, Geoffrey P, Acosta, Juan C, Wellbrock, Claudia, Arozarena, Imanol

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Topographical study of O6-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue von Crosbie, Philip A.J., Harrison, Kathryn, Shah, Rajesh, Watson, Amanda J., Agius, Raymond, Barber, Philip V., Margison, Geoffrey P., Povey, Andrew C.

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O 6-Methylguanine-DNA methyltransferase inactivation and chemotherapy von Verbeek, Barbara, Southgate, Thomas D., Gilham, David E., Margison, Geoffrey P.

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Bladder Tumor Contains Higher N7-Methylguanine Levels in DNA than Adjacent Normal Bladder Epithelium von SAAD, Abir A, O'CONNOR, Peter J, MOSTAFA, Mostafa H, METWALLI, Nabila E, COOPER, Donald P, MARGISON, Geoffrey P, POVEY, Andrew C

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Tumor radiosensitizers—current status of development of various approaches: Report of an International Atomic Energy Agency meeting von Horsman, Michael R., Bohm, Lothar, Margison, Geoffrey P., Milas, Luka, Rosier, Jean-Francois, Safrany, Geza, Selzer, Edgar, Verheij, Marcel, Hendry, Jolyon H.

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