Clonal hematopoiesis: mechanisms driving dominance of stem cell clones von Challen, Grant A., Goodell, Margaret A.

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Stem cells and healthy aging von Goodell, Margaret A., Rando, Thomas A.

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Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response von King, Katherine Y., Goodell, Margaret A.

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Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal von Sun, Deqiang, Luo, Min, Jeong, Mira, Rodriguez, Benjamin, Xia, Zheng, Hannah, Rebecca, Wang, Hui, Le, Thuc, Faull, Kym F., Chen, Rui, Gu, Hongcang, Bock, Christoph, Meissner, Alexander, Göttgens, Berthold, Darlington, Gretchen J., Li, Wei, Goodell, Margaret A.

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DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells von Zhang, Xiaotian, Su, Jianzhong, Jeong, Mira, Ko, Myunggon, Huang, Yun, Park, Hyun Jung, Guzman, Anna, Lei, Yong, Huang, Yung-Hsin, Rao, Anjana, Li, Wei, Goodell, Margaret A

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Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9 von Gundry, Michael C., Brunetti, Lorenzo, Lin, Angelique, Mayle, Allison E., Kitano, Ayumi, Wagner, Dimitrios, Hsu, Joanne I., Hoegenauer, Kevin A., Rooney, Cliona M., Goodell, Margaret A., Nakada, Daisuke

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Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing von Ergen, Aysegul V., Boles, Nathan C., Goodell, Margaret A.

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Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein von Lei, Yong, Zhang, Xiaotian, Su, Jianzhong, Jeong, Mira, Gundry, Michael C., Huang, Yung-Hsin, Zhou, Yubin, Li, Wei, Goodell, Margaret A.

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Mutant NPM1 Maintains the Leukemic State through HOX Expression von Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.

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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy von Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.

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DNA methylation and de-methylation using hybrid site-targeting proteins von Lei, Yong, Huang, Yung-Hsin, Goodell, Margaret A

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Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1 von Challen, Grant A., Boles, Nathan C., Chambers, Stuart M., Goodell, Margaret A.

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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation von Mayle, Allison, Yang, Liubin, Rodriguez, Benjamin, Zhou, Ting, Chang, Edmund, Curry, Choladda V., Challen, Grant A., Li, Wei, Wheeler, David, Rebel, Vivienne I., Goodell, Margaret A.

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Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice von Rossi, Lara, Lin, Kuanyin K., Boles, Nathan C., Yang, Liubin, King, Katherine Y., Jeong, Mira, Mayle, Allison, Goodell, Margaret A.

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Homeobox oncogene activation by pan-cancer DNA hypermethylation von Su, Jianzhong, Huang, Yung-Hsin, Cui, Xiaodong, Wang, Xinyu, Zhang, Xiaotian, Lei, Yong, Xu, Jianfeng, Lin, Xueqiu, Chen, Kaifu, Lv, Jie, Goodell, Margaret A, Li, Wei

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A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells von Kim, Soo Jin, Zhao, Hongbo, Hardikar, Swanand, Singh, Anup Kumar, Goodell, Margaret A., Chen, Taiping

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Acute loss of TET function results in aggressive myeloid cancer in mice von An, Jungeun, González-Avalos, Edahí, Chawla, Ashu, Jeong, Mira, López-Moyado, Isaac F., Li, Wei, Goodell, Margaret A., Chavez, Lukas, Ko, Myunggon, Rao, Anjana

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Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo von Jeong, Mira, Park, Hyun Jung, Celik, Hamza, Ostrander, Elizabeth L., Reyes, Jaime M., Guzman, Anna, Rodriguez, Benjamin, Lei, Yong, Lee, Yeojin, Ding, Lei, Guryanova, Olga A., Li, Wei, Goodell, Margaret A., Challen, Grant A.

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Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners von Sandoval, Jonathan E., Huang, Yung-Hsin, Muise, Abigail, Goodell, Margaret A., Reich, Norbert O.

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DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells von Gu, Tianpeng, Lin, Xueqiu, Cullen, Sean M, Luo, Min, Jeong, Mira, Estecio, Marcos, Shen, Jianjun, Hardikar, Swanand, Sun, Deqiang, Su, Jianzhong, Rux, Danielle, Guzman, Anna, Lee, Minjung, Qi, Lei Stanley, Chen, Jia-Jia, Kyba, Michael, Huang, Yun, Chen, Taiping, Li, Wei, Goodell, Margaret A

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