75 Loss of PTEN leads to acquired resistance to the PI3Ka inhibitor BYL719: a case of convergent evolution under selective therapeutic pressure von Castel, P, Juric, D, Griffith, M, Griffith, O.L, Won, H.H, Ainscough, B, Ellis, H, Ebbesen, S, Gopakumar, I, Quadt, C, Peters, M, Solit, D, Lowe, S.W, Mardis, E.R, Berger, M.F, Scaltriti, M, Baselga, J

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Recurrent DNMT3A mutations in patients with myelodysplastic syndromes von Walter, M J, Ding, L, Shen, D, Shao, J, Grillot, M, McLellan, M, Fulton, R, Schmidt, H, Kalicki-Veizer, J, O'Laughlin, M, Kandoth, C, Baty, J, Westervelt, P, DiPersio, J F, Mardis, E R, Wilson, R K, Ley, T J, Graubert, T A

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Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities von Venkataramany, A.S., Schieffer, K.M., Lee, K., Cottrell, C.E., Wang, P.Y., Mardis, E.R., Cripe, T.P., Chandler, D.S.

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Consensus on precision medicine for metastatic cancers: a report from the MAP conference von Swanton, C., Soria, J.-C., Bardelli, A., Biankin, A., Caldas, C., Chandarlapaty, S., de Koning, L., Dive, C., Feunteun, J., Leung, S.-Y., Marais, R., Mardis, E.R., McGranahan, N., Middleton, G., Quezada, S.A., Rodón, J., Rosenfeld, N., Sotiriou, C., André, F.

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Genomic characterization of HER2-positive breast cancer and response to neoadjuvant trastuzumab and chemotherapy—results from the ACOSOG Z1041 (Alliance) trial von Lesurf, R., Griffith, O.L., Griffith, M., Hundal, J., Trani, L., Watson, M.A., Aft, R., Ellis, M.J., Ota, D., Suman, V.J., Meric-Bernstam, F., Leitch, A.M., Boughey, J.C., Unzeitig, G., Buzdar, A.U., Hunt, K.K., Mardis, E.R.

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A genomic case study of mixed fibrolamellar hepatocellular carcinoma von Griffith, O.L., Griffith, M., Krysiak, K., Magrini, V., Ramu, A., Skidmore, Z.L., Kunisaki, J., Austin, R., McGrath, S., Zhang, J., Demeter, R., Graves, T., Eldred, J.M., Walker, J., Larson, D.E., Maher, C.A., Lin, Y., Chapman, W., Mahadevan, A., Miksad, R., Nasser, I., Hanto, D.W., Mardis, E.R.

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A physical map of the human genome von McPherson, J D, Marra, M, Hillier, L, Waterston, R H, Chinwalla, A, Wallis, J, Sekhon, M, Wylie, K, Mardis, E R, Wilson, R K, Fulton, R, Kucaba, T A, Wagner-McPherson, C, Barbazuk, W B, Gregory, S G, Humphray, S J, French, L, Evans, R S, Bethel, G, Whittaker, A, Holden, J L, McCann, O T, Dunham, A, Soderlund, C, Scott, C E, Bentley, D R, Schuler, G, Chen, H C, Jang, W, Green, E D, Idol, J R, Maduro, V V, Montgomery, K T, Lee, E, Miller, A, Emerling, S, Kucherlapati, Gibbs, R, Scherer, S, Gorrell, J H, Sodergren, E, Clerc-Blankenburg, K, Tabor, P, Naylor, S, Garcia, D, de Jong, P J, Catanese, J J, Nowak, N, Osoegawa, K, Qin, S, Rowen, L, Madan, A, Dors, M, Hood, L, Trask, B, Friedman, C, Massa, H, Cheung, V G, Kirsch, I R, Reid, T, Yonescu, R, Weissenbach, J, Bruls, T, Heilig, R, Branscomb, E, Olsen, A, Doggett, N, Cheng, J F, Hawkins, T, Myers, R M, Shang, J, Ramirez, L, Schmutz, J, Velasquez, O, Dixon, K, Stone, N E, Cox, D R, Haussler, D, Kent, W J, Furey, T, Rogic, S, Kennedy, S, Jones, S, Rosenthal, A, Wen, G, Schilhabel, M, Gloeckner, G, Nyakatura, G, Siebert, R, Schlegelberger, B, Korenberg, J, Chen, X N, Fujiyama, A, Hattori, M, Toyoda, A, Yada, T, Park, H S, Sakaki, Y, Shimizu, N, Asakawa, S

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22. Standardization and systematization of somatic variant refinement using a standard operating procedure and deep learning von Barnell, E.K., Ainscough, B.A., Campbell, K.M., Rohan, T.E., Govindan, R., Mardis, E.R., Swamidass, S.J., Griffith, M., Griffith, O.L.

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High-throughput detergent extraction of M13 subclones for fluorescent DNA sequencing von Mardis, E.R

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The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis von Cui, J., Diogo, D., Stahl, E.A., Canhao, H., Mariette, X., Greenberg, J.D., Okada, Y., Pappas, D.A., Fulton, R.S., Tak, P.P., Nurmohamed, M.T., Lee, A., Larson, D.E., Kurreeman, F., Deluca, T.L., O'Laughlin, M., Fronick, C.C., Fulton, L.L., Mardis, E.R., Horst-Bruinsma, I.E. van der, Wolbink, G.J., Gregersen, P.K., Kremer, J.M., Crusius, J.B.A., Vries, N. de, Huizinga, T.W.J., Fonseca, J.E., Miceli-Richard, C., Karlson, E.W., Coenen, M.J.H., Barton, A., Plenge, R.M., Raychaudhuri, S.

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Modification of a commercially available DNA sequencer to increase sample throughput von Stuebe, E.T., Steward, J.Q., Chinwalia, A., Cook, L.L., Cook, M., Fronick, B., Miller, K., Mullen, M.K., O'Brien, D., Panussis, D.A., Pohl, C., Snider, J.E., Strong, J., Williams, D., Wilson, R.K., Tibbets, C., Mardis, E.R.

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Engineering in genomics. Technical improvements in high throughput genome sequencing von Mardis, E.R.

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