Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art von Marcsisin, Sean R, Reichard, Gregory, Pybus, Brandon S

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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6 von Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor

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A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bit... von Murphy, Sean C, Duke, Elizabeth R, Shipman, Kelly J, Jensen, Ryan L, Fong, Youyi, Ferguson, Sue, Janes, Holly E, Gillespie, Kevin, Seilie, Annette M, Hanron, Amelia E, Rinn, Laurie, Fishbaugher, Matthew, VonGoedert, Tracie, Fritzen, Emma, Kappe, Stefan H, Chang, Ming, Sousa, Jason C, Marcsisin, Sean R, Chalon, Stephan, Duparc, Stephan, Kerr, Nicola, Möhrle, Jörg J, Andenmatten, Nicole, Rueckle, Thomas, Kublin, James G

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Hydrogen exchange mass spectrometry: what is it and what can it tell us? von Marcsisin, Sean R., Engen, John R.

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Enantioselective metabolism of primaquine by human CYP2D6 von Fasinu, Pius S, Tekwani, Babu L, Nanayakkara, N P Dhammika, Avula, Bharathi, Herath, H M T Bandara, Wang, Yan-Hong, Adelli, Vijender R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Pybus, Brandon S, Marcsisin, Sean R, Reichard, Gregory A, McChesney, James D, Walker, Larry A

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Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes von Fasinu, Pius S, Avula, Bharathi, Tekwani, Babu L, Nanayakkara, N P Dhammika, Wang, Yan-Hong, Bandara Herath, H M T, McChesney, James D, Reichard, Gregory A, Marcsisin, Sean R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Walker, Larry A

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On the Solution Conformation and Dynamics of the HIV-1 Viral Infectivity Factor von Marcsisin, Sean R., Narute, Purushottam S., Emert-Sedlak, Lori A., Kloczewiak, Marek, Smithgall, Thomas E., Engen, John R.

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Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly von Chaikuad, Apirat, Filippakopoulos, Panagis, Marcsisin, Sean R., Picaud, Sarah, Schröder, Martin, Sekine, Shiori, Ichijo, Hidenori, Engen, John R., Takeda, Kohsuke, Knapp, Stefan

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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population von Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, McCarthy, William F, Waters, Norman C, Smith, Philip L, Reichard, Gregory A, Bennett, Jason W

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Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults von Healy, Sara A, Murphy, Sean C, Hume, Jen C C, Shelton, Lisa, Kuntz, Steve, Van Voorhis, Wesley C, Moodie, Zoe, Metch, Barbara, Wang, Ruobing, Silver-Brace, Tiffany, Fishbaugher, Matthew, Kennedy, Mark, Finney, Olivia C, Chaturvedi, Richa, Marcsisin, Sean R, Hobbs, Charlotte V, Warner-Lubin, Margaret, Talley, Angela K, Wong-Madden, Sharon, Stuart, Ken, Wald, Anna, Kappe, Stefan H, Kublin, James G, Duffy, Patrick E

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Comparison of Anti-Xa Activity in Patients Receiving Apixaban or Rivaroxaban von Bookstaver, David A., Sparks, Kimberly, Pybus, Brandon S., Davis, Dustin K., Marcsisin, Sean R., Sousa, Jason C.

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Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds von Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Dhammika Nanayakkara, N P, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S

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Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations von Jin, Xiannu, Luong, Thu-Lan, Reese, Necole, Gaona, Heather, Collazo-Velez, Vanessa, Vuong, Chau, Potter, Brittney, Sousa, Jason C., Olmeda, Raul, Li, Qigui, Xie, Lisa, Zhang, Jing, Zhang, Ping, Reichard, Greg, Melendez, Victor, Marcsisin, Sean R., Pybus, Brandon S.

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Differential CYP 2D6 metabolism alters primaquine pharmacokinetics von Potter, Brittney M J, Xie, Lisa H, Vuong, Chau, Zhang, Jing, Zhang, Ping, Duan, Dehui, Luong, Thu-Lan T, Bandara Herath, H M T, Dhammika Nanayakkara, N P, Tekwani, Babu L, Walker, Larry A, Nolan, Christina K, Sciotti, Richard J, Zottig, Victor E, Smith, Philip L, Paris, Robert M, Read, Lisa T, Li, Qigui, Pybus, Brandon S, Sousa, Jason C, Reichard, Gregory A, Marcsisin, Sean R

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Molecular Insight into the Conformational Dynamics of the Elongin BC Complex and Its Interaction with HIV-1 Vif von Marcsisin, Sean R., Engen, John R.

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Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics von Vuong, Chau, Xie, Lisa H, Potter, Brittney M J, Zhang, Jing, Zhang, Ping, Duan, Dehui, Nolan, Christina K, Sciotti, Richard J, Zottig, Victor E, Nanayakkara, N P Dhammika, Tekwani, Babu L, Walker, Larry A, Smith, Philip L, Paris, Robert M, Read, Lisa T, Li, Qigui, Pybus, Brandon S, Sousa, Jason C, Reichard, Gregory A, Smith, Bryan, Marcsisin, Sean R

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Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei von Milner, Erin E, Berman, Jonathan, Caridha, Diana, Dickson, Samuel P, Hickman, Mark, Lee, Patricia J, Marcsisin, Sean R, Read, Lisa T, Roncal, Norma, Vesely, Brian A, Xie, Lisa H, Zhang, Jing, Zhang, Ping, Li, Qigui

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Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs von Wickham, Kristina S, Baresel, Paul C, Marcsisin, Sean R, Sousa, Jason, Vuong, Chau T, Reichard, Gregory A, Campo, Brice, Tekwani, Babu L, Walker, Larry A, Rochford, Rosemary

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Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe von Marcsisin, Sean R, Liptak, Cary, Marineau, Jason, Bradner, James E, Engen, John R

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Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats von Mountney, Andrea, Shear, Deborah A, Potter, Brittney, Marcsisin, Sean R, Sousa, Jason, Melendez, Victor, Tortella, Frank C, Lu, Xi-Chun M

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