Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1 von Marcin, Lawrence R., Higgins, Mendi A., Zusi, F. Christopher, Zhang, Yunhui, Dee, Michael F., Parker, Michael F., Muckelbauer, Jodi K., Camac, Daniel M., Morin, Paul E., Ramamurthy, Vidhyashankar, Tebben, Andrew J., Lentz, Kimberley A., Grace, James E., Marcinkeviciene, Jovita A., Kopcho, Lisa M., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Meredith, Jere E., Albright, Charles F., Bronson, Joanne J., Macor, John E., Thompson, Lorin A.

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NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis von Miesel, L, Weisbrod, T R, Marcinkeviciene, J A, Bittman, R, Jacobs, Jr, W R

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The Role of Mn(II)-Peroxidase Activity of Mycobacterial Catalase-Peroxidase in Activation of the Antibiotic Isoniazid von Magliozzo, R S, Marcinkeviciene, J A

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Purification and Characterization of the Mycobacterium smegmatis Catalase-Peroxidase Involved in Isoniazid Activation (∗) von Marcinkeviciene, Jovita A., Magliozzo, Richard S., Blanchard, John S.

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Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties von Wilson, Theresa, de Lisle, Geoffrey W, Marcinkeviciene, Jovita A, Blanchardand, John S, Collins, Desmond M

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Evidence for Isoniazid Oxidation by Oxyferrous Mycobacterial Catalase−Peroxidase von Magliozzo, Richard S, Marcinkeviciene, Jovita A

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Quinone reductase reaction catalyzed by Streptococcus faecalis NADH peroxidase von Marcinkeviciene, Jovita A, Blanchard, John S

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A negative cooperativity between NADPH and adrenodoxin on binding to NADPH:adrenodoxin reductase von Čénas, Narimantas K., Marcinkevičiene, Jovita A., Kulys, Juozas J., Usanov, Sergey A.

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Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes von Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G

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Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase von Rigat, Karen L., Lu, Hao, Wang, Ying-Kai, Argyrou, Argyrides, Fanslau, Caroline, Beno, Brett, Wang, Yi, Marcinkeviciene, Jovita, Ding, Min, Gentles, Robert G., Gao, Min, Abell, Lynn M., Roberts, Susan B.

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Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation von Metzler, William J., Yanchunas, Joseph, Weigelt, Carolyn, Kish, Kevin, Klei, Herbert E., Xie, Dianlin, Zhang, Yaqun, Corbett, Martin, Tamura, James K., He, Bin, Hamann, Lawrence G., Kirby, Mark S., Marcinkeviciene, Jovita

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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors von Regard, Jean B., Harrison, Tyler J., Axford, Jake, Axford, Laura, Lee, Lac, Ren, Xianglin, Deng, Lin, Reynolds, Aimee, Mao, Justin, Liu, Qian, Patnaik, Anup, Cohick, Evan, Hollis-Symynkywicz, Micah, Loi, Sally, Riek, Simone, McKeever, Una, Dunstan, David, Sung, MooJe, Ware, Nathaniel F., Brown, Alan P., Hamann, Lawrence G., Marcinkeviciene, Jovita, Patterson, Andrew W., Marro, Martin L.

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Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO) von Patnaik, Anup, Axford, Laura, Deng, Lin, Cohick, Evan, Ren, Xianglin, Loi, Sally, Kecman, Sam, Hollis-Symynkywicz, Micah, Harrison, Tyler J., Papillon, Julien P.N., Dales, Natalie, Hamann, Lawrence G., Lee, Lac, Regard, Jean B., Marcinkeviciene, Jovita, Marro, Martin L., Patterson, Andrew W.

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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphon... von Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O'Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Jr, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T W

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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor von Marro, Martin L, Patterson, Andrew W, Lee, Lac, Deng, Lin, Reynolds, Aimee, Ren, Xianglin, Axford, Laura, Patnaik, Anup, Hollis-Symynkywicz, Micah, Casson, Nigel, Custeau, Dominique, Ames, Lisa, Loi, Sally, Zhang, Lihe, Honda, Toshiyuki, Blank, Jutta, Harrison, Tyler J, Papillon, Julien P N, Hamann, Lawrence G, Marcinkeviciene, Jovita, Regard, Jean B

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Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors von Zhao, Guohua, Kwon, Chet, Wang, Aiying, Robertson, James G., Marcinkeviciene, Jovita, Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.

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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonat... von Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K. Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O’Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T. W

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A Pre-Steady State Analysis of Ligand Binding to Human Glucokinase:  Evidence for a Preexisting Equilibrium von Kim, Young B, Kalinowski, Stephen S, Marcinkeviciene, Jovita

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Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors von Meng, Wei, Brigance, Robert P, Chao, Hannguang J, Fura, Aberra, Harrity, Thomas, Marcinkeviciene, Jovita, O’Connor, Stephen P, Tamura, James K, Xie, Dianlin, Zhang, Yaqun, Klei, Herbert E, Kish, Kevin, Weigelt, Carolyn A, Turdi, Huji, Wang, Aiying, Zahler, Robert, Kirby, Mark S, Hamann, Lawrence G

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Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118) von Kim, Young B., Kopcho, Lisa M., Kirby, Mark S., Hamann, Lawrence G., Weigelt, Carolyn A., Metzler, William J., Marcinkeviciene, Jovita

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